We study a class of two-dimensional non-linear Schrödinger equations with point-like singular perturbation and Hartree non-linearity. The point-like singular perturbation of the free Laplacian induces appropriate perturbed Sobolev spaces that are necessary for the study of ground states and evolution flow. We include in our treatment both mass sub-critical and mass critical Hartree non-linearities. Our analysis is two-fold: we establish existence, symmetry, and regularity of ground states, and we demonstrate the well-posedness of the associated Cauchy problem in the singular perturbed energy space. The first goal, unlike other treatments emerging in parallel with the present work, is achieved by a non-trivial adaptation of the standard properties of Schwartz symmetrisation for the modified Weinstein functional. This produces, among others, modified Gagliardo-Nirenberg type inequalities that allow to efficiently control the non-linearity and obtain well-posedness by energy methods. The evolution flow is proved to be global in time in the defocusing case, and in the focusing and mass sub-critical case. It is also global in the focusing and mass critical case, for initial data that are suitably small in terms of the best Gagliardo-Nirenberg constant.