Global graying, colorectal cancer and liver metastasis: New implications for surgical management

Anaya, Daniel A.; Becker, Natasha S.; Abraham, Neena S.

doi:10.1016/j.critrevonc.2010.02.003

Cited by 43 publications

(39 citation statements)

References 89 publications

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“…Treatment trials show their higher or lower effectiveness based on at what stage the cancer was detected in the patients and the age of the patients where outcomes for the elderly have been worse compared to younger patients. Nonetheless, standard-of-care treatment for the elderly patients result in equivalent long-term outcomes to those observed in the younger population; and available data support the use of aggressive surgery and adjuvant therapies in well-selected patients [7]. In patients all the methods should not be tried at once because it may be ineffective and sometimes even harmful.…”

Section: Introductionmentioning

confidence: 99%

Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis

Mishra

Drummond²,

Quazi

et al. 2013

Critical Reviews in Oncology/Hematology

165

117

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Colorectal cancer is the leading cause of cancer-related mortality in the western world. It is also the third most common cancer diagnosed in both men and women in the United States with a recent estimate for new cases of colorectal cancer in the year 2012 being around 103,170. Various risk factors for colorectal cancer include life-style, diet, age, personal and family history, and racial and ethnic background. While a few cancers are certainly preventable but this does not hold true for colon cancer as it is often detected in its advanced stage and generally not diagnosed until symptoms become apparent. Despite the fact that several options are available for treating this cancer through surgery, chemotherapy, radiation therapy, immunotherapy, and nutritional-supplement therapy, but the success rates are not very encouraging when used alone where secondary complications appear in almost all these therapies. To maximize the therapeutic-effects in patients, combinatorial approaches are essential. In this review we have discussed the therapies previously and currently available to patients diagnosed with colorectal-cancer, focus on some recent developments in basic research that has shaded lights on new therapeutic-concepts utilizing macrophages/dendritic cells, natural killer cells, gene delivery, siRNA-, and microRNA-technology, and specific-targeting of tyrosine kinases that are either mutated or over-expressed in the cancerous cell to treat these cancer. Potential strategies are discussed where these concepts could be applied to the existing therapies under a comprehensive approach to enhance the therapeutic effects.

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Section: Introductionmentioning

confidence: 99%

Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis

Mishra

Drummond²,

Quazi

et al. 2013

Critical Reviews in Oncology/Hematology

165

117

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“…Despite these encouraging findings, the role of surgery in liver metastases in elderly patients has not been clearly defined . Given that cancer is a disease that predominantly affects elderly people, and in view of the expected sustained growth of this segment of the population, the proportion of patients with liver metastases aged > 65 years will continue to increase and surgical treatment – hepatectomy – should be part of the armamentarium for the optimal management of their disease .…”

Section: Introductionmentioning

confidence: 99%

Postoperative mortality and need for transitional care following liver resection for metastatic disease in elderly patients: a population‐level analysis of 4026 patients

Orcutt

Artinyan

et al. 2012

HPB

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Although increasing age was associated with higher risk for in-hospital mortality, the absolute risk was low and within accepted ranges, and comorbidity was the primary driver of mortality. Conversely, need for transitional care was significantly more common in elderly patients. Therefore, liver resection for metastases is safe in well-selected elderly patients, although consideration should be made for potential transitional care needs.

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“…We found that older patients were less likely to receive treatment. These differences may reflect providers' biases against aggressive management of elderly patients 10,[26][27][28][29] and patients with what may be perceived as more biologically aggressive disease. 30 Elderly patients undergoing surgical treatment for CRC-LM may have similar outcomes to younger patients, and treatment should not be withheld based solely on age.…”

Section: Crc-lm Colorectal Cancer Liver Metastases Va Veterans Affairsmentioning

confidence: 94%

Patterns of Care for Colorectal Liver Metastasis Within an Integrated Health System: Secular Trends and Outcomes

Orcutt

Massarweh

et al. 2016

Ann Surg Oncol

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The proportion of CRC-LM patients receiving treatment within the largest integrated health system in the US (VA health system) has increased substantially over time; however, one in three patients still does not receive any treatment. Future initiatives should focus on increasing treatment among older patients as well as on evaluating reasons leading to the no-treatment approach and increased use of ablation procedures.

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Global graying, colorectal cancer and liver metastasis: New implications for surgical management

Cited by 43 publications

References 89 publications

Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis

Prospective of colon cancer treatments and scope for combinatorial approach to enhanced cancer cell apoptosis

Postoperative mortality and need for transitional care following liver resection for metastatic disease in elderly patients: a population‐level analysis of 4026 patients

Patterns of Care for Colorectal Liver Metastasis Within an Integrated Health System: Secular Trends and Outcomes

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