Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM

Chen, Sharon C‐A; Perfect, John R.; Colombo, Arnaldo Lopes; Cornely, Oliver A.; Groll, Andreas H.; Seidel, Danila; Albus, Kerstin; Almedia, Joao N de; García‐Effrón, Guillermo; Gilroy, Nicole; Lass‐Flörl, Cornelia; Ostrosky‐Zeichner, Luis; Pagano, Livio; Papp, Tamas; Rautemaa‐Richardson, Riina; Salmanton‐García, Jon; Spec, Andrej; Steinmann, Joerg; Arıkan-Akdağlı, Sevtap; Arenz, Dorothee; Sprute, Rosanne; Durán-Graeff, Luisa; Freiberger, Tomáš; Girmenia, Corrado; Harris, Michelle; Kanj, Souha S.; Roudbary, Maryam; Lortholary, Olivier; Meletiadis, Joseph; Segal, Esther; Tuon, Felipe Francisco; Wiederhold, Nathan P.; Bicanic, Tihana; Chander, Jagdish; Chen, Yee‐Chun; Hsueh, Po‐Ren; Ip, Margaret; Muñóz, Patricia; Spriet, Isabel; Temfack, Elvis; Thompson, Luis; Tortorano, A.M.; Velegraki, Aristea; Govender, Nelesh P.

doi:10.1016/s1473-3099(21)00203-6

Cited by 121 publications

(195 citation statements)

References 68 publications

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“…However, Bruker Autoflex Speed (Bruker Daltonics, Bremen, Germany) contains the mass spectral data of T. dohaense and can reliably identify it [ 10 ]. Sequencing-based platforms targeting the ITS (ITS1-5.8S-ITS2) and LSU regions of fungal DNA have high discriminatory power and can provide accurate identification to the species level [ 8 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown azole-based therapy to be superior to polyene-based therapy for the treatment of invasive trichosporonosis. Azole-polyene combination therapy has no advantage over azole monotherapy [ 12 , 18 , 20 ]. According to the Global guideline for the diagnosis and management of rare yeast infections issued by European Confederation of Medical Mycology (ECMM) in co-operation with International Society for Human and Animal Mycology (ISHAM) and American Society for Microbiology (ASM), treatment of invasive trichosporonosis should consist of either voriconazole or posaconazole for a duration of 4–6 weeks, or until radiological resolution (moderate recommendation) [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

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COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

Samaddar

Diwakar

Krishnan

et al. 2022

Medical Mycology Case Reports

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We report the first case of Coronavirus Disease 2019 (COVID-19)-associated brain abscess caused by a rare Trichosporon species, T. dohaense . The patient was a known diabetic and had received systemic corticosteroids for the treatment of COVID-19. He underwent craniotomy and evacuation of abscess. The pus aspirate grew a basidiomycetous yeast, morphologically resembling Trichosporon species. The isolate was initially misidentified by VITEK® MS due to lack of mass spectral database of T. dohaense . Accurate identification was achieved by internal transcribed spacer-directed panfungal polymerase chain reaction. The patient had a favorable outcome following surgical intervention and antifungal therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

Samaddar

Diwakar

Krishnan

et al. 2022

Medical Mycology Case Reports

View full text Add to dashboard Cite

show abstract

“…Intrinsic resistance of non-Aspergillus moulds to antifungal agents is frequent, and mortality appears to exceed 50% for most of the non-Aspergillus moulds. Of note, new guidelines have been published on mucormycosis, rare moulds and rare yeasts; these include paediatric-specific recommendations (90)(91)(92).…”

Section: Management Of Fungal Infectionsmentioning

confidence: 99%

“…General management principles for IFDs are well established and include the prompt initiation of appropriate antifungal therapy, identification and resistance testing of all invasive isolates, source control, and management of predisposing conditions, as feasible (94). Echinocandins or liposomal amphotericin B (95)(96)(97) are strongly recommended for the (91,92).…”

Section: Management Of Fungal Infectionsmentioning

confidence: 99%

“…Echinocandins or liposomal amphotericin B ( 95 – 97 ) are strongly recommended for the first-line treatment of invasive Candida infections before species identification, and voriconazole and liposomal amphotericin B for first-line treatment of invasive aspergillosis ( 98 , 99 ). Recommendations for mucormycosis, rare moulds and rare yeasts are beyond the scope of this article but have been updated recently by the European Confederation of Medical Mycology (ECMM) consortium ( 90 – 92 ) ( Table 3 ).…”

Section: Administration Of Immunoglobulinsmentioning

confidence: 99%

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Infectious Complications in Paediatric Haematopoetic Cell Transplantation for Acute Lymphoblastic Leukemia: Current Status

et al. 2022

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Haematopoietic stem cell transplantation (HSCT) in paediatric patients with acute lymphoblastic leukaemia (ALL) is associated with a variety of infectious complications which result in significant morbidity and mortality. These patients are profoundly immunocompromised, and immune reconstitution after HSCT generally occurs in astrictly defined order. During the early phase after HSCT until engraftment, patients are at risk of infections due to presence of neutropenia and mucosal damage, with Gramme-positive and Gramme-negative bacteria and fungi being the predominant pathogens. After neutrophil recovery, the profound impairment of cell-mediated immunity and use of glucocorticosteroids for control of graft-vs.-host disease (GvHD) increases the risk of invasive mould infection and infection or reactivation of various viruses, such as cytomegalovirus, varicella zoster virus, Epstein-Barr virus and human adenovirus. In the late phase, characterised by impaired cellular and humoral immunity, particularly in conjunction with chronic GvHD, invasive infections with encapsulated bacterial infections are observed in addition to fungal and viral infections. HSCT also causes a loss of pretransplant naturally acquired and vaccine-acquired immunity; therefore, complete reimmunization is necessary to maintain long-term health in these patients. During the last two decades, major advances have been made in our understanding of and in the control of infectious complications associated with HSCT. In this article, we review current recommendations for the diagnosis, prophylaxis and treatment of infectious complications following HSCT for ALL in childhood.

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Successful management with urgent haploidentical‐peripheral blood stem cell transplantation for a patient with severe aplastic anaemia who developed disseminated fungal infection following immunosuppressive therapy

Ikenobe,

Fujimori,

Gocho

et al. 2024

eJHaem

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Urgent haploidentical haematopoietic cell transplantation may be considered in cases of severe aplastic anaemia (SAA) without a human leukocyte antigen‐matched donor and suffering from severe infection. However, deciding on allogeneic transplantation in the setting of active systemic infection is challenging due to poor outcomes. This report presents a case of disseminated Magnusiomyces capitatus infection in a 5‐year‐old male who underwent immunosuppressive therapy for hepatitis‐associated SAA. To address the critical situation, granulocyte transfusion was promptly administered from the patient's mother, followed by unmanipulated haploidentical peripheral blood stem cell transplantation from the patient's father with posttransplant cyclophosphamide, ultimately resulting in successful rescue.

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Global guideline for the diagnosis and management of rare yeast infections: an initiative of the ECMM in cooperation with ISHAM and ASM

Cited by 121 publications

References 68 publications

COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

COVID-19-associated brain abscess caused by Trichosporon dohaense: A case report and review of literature

Infectious Complications in Paediatric Haematopoetic Cell Transplantation for Acute Lymphoblastic Leukemia: Current Status

Successful management with urgent haploidentical‐peripheral blood stem cell transplantation for a patient with severe aplastic anaemia who developed disseminated fungal infection following immunosuppressive therapy

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