Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis

Abstract

The global incidence of acute pancreatitis is increasing over time:A systematic review and meta-analysis• 34 studies in adults reported temporal incidence of acute pancreatitis in over time. • Incidence of acute pancreatitis has increased over time with an average annual percent change (AAPC) of 3.07%.No difference in incidence rates between women and men.AAPC of biliary and alcohol induced pancreatitis have increased but without significant differences in rate of increase. = BACKGROUND& AIMS: Acute pancreatitis is a common disease with significant associated morbidity and mortality. We performed a systematic review and meta-analysis of population-based studies to explore the changing temporal trends of acute pancreatitis incidence globally. METHODS: We performed a systematic literature search to identify populationbased studies reporting the annual incidence of acute pancreatitis. Abstracts were assessed independently to identify applicable articles for full-text review and data extraction. Joinpoint temporal trend analyses were performed to calculate the average annual percent change (AAPC) with 95% confidence intervals (CIs). The AAPCs were pooled in a metaanalysis to capture the overall and regional trends in acute pancreatitis incidence over time. Temporal data were summarized in a static map and an interactive, web-based map. RESULTS: Forty-four studies reported the temporal incidence of acute pancreatitis (online interactive map: https://kaplanacute-pancreatitis-ucalgary.hub.arcgis.com/). The incidence of acute pancreatitis has increased from 1961 to 2016 (AAPC, 3.07%; 95% CI, Q3 2.30% to 3.84%; n ¼ Q4 34). Increasing incidence was observed in North America (AAPC, 3.67%; 95% CI, 2.76% to 4.57%; n ¼ 4) and Europe (AAPC, 2.77%; 95% CI, 1.91% to 3.63%; n ¼ 23). The incidence of acute pancreatitis was stable in Asia (AAPC, -0.28%; 95% CI, -5.03% to 4.47%; n ¼ 4). CONCLUSIONS: This meta-analysis provides a comprehensive overview of the global incidence of acute pancreatitis over the last 56 years and demonstrates a steadily rising incidence over time in most countries of the Western world. More studies are needed to better define the changing incidence of acute pancreatitis in Asia, Africa, and Latin America.

Alteration of Peripheral Resistin and the Severity of Acute Pancreatitis: A Meta-Analysis

“…Pancreatic injury is mild and self-limiting in approximately 80% of patients with AP that would find their health after brief hospitalization. Unfortunately, the other 20% of patients with AP would develop lethal severe acute pancreatitis (SAP) that requires intensive care ( 2 , 3 ). Despite improvements in treatment measurements and supportive care, SAP remains one of the important causes of death during the past decade ( 4 ).…”

Transcriptomics and Network Pharmacology Reveal the Protective Effect of Chaiqin Chengqi Decoction on Obesity-Related Alcohol-Induced Acute Pancreatitis via Oxidative Stress and PI3K/Akt Signaling Pathway

“…Acute pancreatitis (AP) is an inflammatory disease of the pancreas ( Mederos et al, 2021 ), which shows a steady rise in the global incidence over the last 50 years ( Iannuzzi et al, 2021 ). The clinical manifestation of AP varies from asymptomatic/mild to severe cases characterized by extensive pancreatic necrosis, multi-organ failure, and significant mortality ( Garg and Singh, 2019 ).…”

Hydroxyurea-Induced Acute Pancreatitis

“…Each year in the US, well over 100,000 hospital admissions occur due to acute pancreatitis, with drug-induced pancreatitis (DIP) accounting for a minority of these cases (less than 3%) [ 1 ]. Over the last half-century, a steady rise in the incidence of acute pancreatitis in Western countries has been identified [ 2 ]. It remains imperative to recognize acute pancreatitis as it contributes to the economic burden on healthcare due to increased hospital readmission and excessive work-up cost.…”

“…A plethora of new medications are regularly being introduced to the pharmaceutical market and administered by clinicians, resulting in an increased number of drugs that could potentially be implicated in DIP. The source of the available data in DIP originates from case series, case reports, or case-control studies [ 2 ]. This is a case report of acute pancreatitis attributed to the use of hydroxyurea, a medication not well known to be associated with pancreatitis.…”