Global Indian Diasporas : Exploring Trajectories of Migration and Theory

Oonk, Gijsbert

doi:10.5117/9789053560358

Cited by 42 publications

(3 citation statements)

References 24 publications

(26 reference statements)

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“…It demonstrates the relationship with European strains; a study described that there was a sizeable community of South Asians like Asian labor migrants settled in European countries. Currently, approximately two million South Asians are living in Africa; some came in late nineteen and early twentieth century [47]. The phylogenetic analysis depicts that viral genome underwent various significant changes with time at different rates in which core region is considered to be more diverse [48].…”

Section: Discussionmentioning

confidence: 99%

“…Different domains of core perform different functions like siRNA predicted against all the genotypes (3a, 4a and 3b) positioned at N-terminal from 13-35 nucleotides contains RNA and DNA binding domain [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][54]. N- Terminal of core induces apoptosis and necrosis higher than those of C-terminal [55].…”

Section: Discussionmentioning

confidence: 99%

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Hepatitis C Viral Heterogeneity Based on Core Gene and an Attempt to Design Small Interfering RNA Against Strains Resistant to Interferon in Rawalpindi, Pakistan

Kanwal

Mahmood²

2012

Hepat Mon

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Background Global prevalence of Hepatitis C Virus (HCV) infection corresponds to about 130 million HCV positive patients worldwide. The only drug that effectively reduces viral load is interferon-α (IFN-α) and currently combination of IFN and ribavirin is the choice for treatment. Objectives The present study is aimed to resolve the genotypes based on core gene that might affect the response to interferon therapy. Furthermore an attempt was made to propose a powerful therapeutic approach by designing the siRNA from sequences of the same patients who remain resistant to IFN in this study. Patients and Methods To achieve the objectives, a sequence analysis was performed in five HCV ELISA positive subjects who have completed IFN treatment. Neighbor Joining (NJ) method was used to study the evolutionary relationship. Atomic models were predicted using online software PROCHECK and i- TASSER. Results Two new genotypes were reported for the first time namely 4a from suburban region of Rawalpindi and 6e from all over the Pakistan. According to Ramachandran plot, satisfactory atomic model was considered useful for further studies, i.e. to calculate HCV genotypes conservation at structural level, to find out critical binding sites for drug designing, or to silence those binding sites by using appropriate siRNA. Single siRNA can be used to inhibit HCV RNA synthesis against genotype 3 and 4, as the predicted siRNA were originated from the same domain in studied HCV core region in both genotypes. Conclusions We can conclude that any change or mutation in core region might be the cause of HCV strains to resist against IFN therapy. Therefore, further understanding of the complex mechanism involved in disrupting viral response to therapy would facilitate the development of more effective therapeutic regimens. Additionally, a single designed siRNA can be used as an alternative for current therapy against more than one resistant HCV genotypes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hepatitis C Viral Heterogeneity Based on Core Gene and an Attempt to Design Small Interfering RNA Against Strains Resistant to Interferon in Rawalpindi, Pakistan

Kanwal

Mahmood²

2012

Hepat Mon

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“…The South Asian diaspora is a much researched field (cf. Bates, 2001;Jacobsen & Pratap 204;Lal, 2006;Oonk, 2007). It has been constituted by very diverse migration movements from the area now defined as South Asia at least since colonial times and stretches across most of the world.…”

mentioning

confidence: 99%

The Indernet

Goel

2016

International Journal of E-Politics

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The social web creates a different technological environment for natio-ethno-cultural community building than internet portals did. Using a long-term ethnography of the virtual space Indernet, the article pursues the question, why after a relaunch of the former internet portal as a blog and a Facebook page it no longer functioned as a space of the second generation. In particular it analyses which demographic and technological factors had an impact on the capacity for community building. The article argues that the individualised usage of social media and the flow of Facebook make it much harder for ethnic entrepreneurs to create a space of natio-ethno-cultural belonging.

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Diaspora Remittances and Sustainable Development in Africa: The Case Study of Nigeria

Nkwede

Dauda

Moliki

et al. 2020

Pan Africanism, Regional Integration and Development in Africa

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Global Indian Diasporas : Exploring Trajectories of Migration and Theory

Abstract: E d i t e d b y G i j s b e r t O o n k a m s t e r d a m u n i v e r s i t y p r e s sGlobal Indian Diasporas

Cited by 42 publications

References 24 publications

Hepatitis C Viral Heterogeneity Based on Core Gene and an Attempt to Design Small Interfering RNA Against Strains Resistant to Interferon in Rawalpindi, Pakistan

Hepatitis C Viral Heterogeneity Based on Core Gene and an Attempt to Design Small Interfering RNA Against Strains Resistant to Interferon in Rawalpindi, Pakistan

The Indernet

Diaspora Remittances and Sustainable Development in Africa: The Case Study of Nigeria

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