Global landscape of COVID-19 and epilepsy research: A bibliometric analysis

Wang, Guangxin; Bai, Lan; Zhao, Mingbo; Wang, Shumei

doi:10.3389/fneur.2022.1034070

Cited by 3 publications

(3 citation statements)

References 48 publications

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“…As we delved into understanding relationship between COVID-19 and epilepsy, there COVID-19 has presented significant challenges for individuals with pre-existing epilepsy, manifesting in altered seizure frequencies independent of COVID-19 infection. The potential exacerbation of seizures in COVID-19 patients, particularly due to fever-induced seizures, underscores the intricate relationship between the virus and neurological conditions like epilepsy (Wang et al, 2022). Additionally, severe COVID-19 illness has been linked to complications such as hypoxic encephalopathy and cytokine storms, further elevating the risk of seizures in epilepsy patients.…”

Section: Discussionmentioning

confidence: 99%

Unraveling the Shared Genetic Elements Among COVID-19 and Epilepsy: A Computational and Bioinformatics Analysis

Nagendran,

Murugesan,

Natarajan

2024

MEDIN

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The outbreak of COVID-19 linked to the SARS-CoV-2 virus has raised worries about its potential to worsen pre-existing health issues such as autoimmune conditions. One common autoimmune condition seen across all individuals is epilepsy. Our detailed computational study examined the complex connection between COVID-19 and epilepsy, with a focus on their possible impact on neurodegenerative disorders. Leveraging transcriptome analysis, we aimed to interpret shared pathways and molecular biomarkers between COVID-19 and epilepsy using RNA-seq datasets. Cutting-edge bioinformatics tools facilitated Network, Enrichment, and route analysis, along with the identification of pivotal gene signatures, notably through comprehensive exploration of machine learning methods and protein-protein interactions. This work identified 1040 common differentially expressed genes (DEGs), forming the basis for unraveling shared pathways and potential drug targets. By employing statistical methods and diverse network analyses, we meticulously identified genetic elements shared between COVID-19 and epilepsy. The analysis reveals that 10 key genes, including CATIP, CDC25C, GPR132, NTS, PDE8B, PLK1, SLC12A9, SPC25, TUBAIA, and TYMS, are crucial in bridging transcriptomic alterations across various scenarios. A subset of these genes exhibited existence within distinct regulatory networks, signifying their significant role in the shared disease mechanisms of COVID-19 and epilepsy. Notably, CDC25C, PLK1, and TYMS emerged as prominent genes within the COVID-19 and epilepsy networks, strongly suggesting their vital roles in connecting regulatory mechanisms across these conditions. Further validation through molecular docking studies will confirm the significance of CDC25C, PLK1, and TYMS, potentially shedding light on new opportunities for targeted therapeutic interventions aimed at reducing the risk of seizures in individuals affected by COVID-19 and epilepsy.

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Section: Discussionmentioning

confidence: 99%

Unraveling the Shared Genetic Elements Among COVID-19 and Epilepsy: A Computational and Bioinformatics Analysis

Nagendran,

Murugesan,

Natarajan

2024

MEDIN

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“…Research indicates that these individuals exhibit elevated levels of factor VIII, brinogen, and D-dimer, all of which are directly involved in the coagulation process. 19,20 It is important to remember that the ACE2 enzyme is known as a critical enzyme in the renin-angiotensin system (RAS), which regulates blood pressure, uid and electrolyte balance, and vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights in a Brazilian Stroke Center

de Oliveira,

Gagliardi

2024

Preprint

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Introduction: More than three years into the ongoing pandemic, cerebrovascular accidents (CVAs), commonly known as strokes,have been extensively documented as a potential complication of COVID-19. Methods: Between the first and second epidemiologicalwaves of deaths, our service recorded 1,461 cases of acute respiratory syndrome with positive tests for the COVID-19 virus.During the same period, 595 patients were reported with hospitalizations/complications related to cerebrovascular syndromes.The study included a cohort of 17 patients experiencing cerebrovascular incidents, with ischemic strokes in 10 cases andhemorrhagic strokes in 7 cases. Results: The mean age was 59.8 years with a standard deviation of 14.6 years, and there was aslight female predominance with 9 female patients (52.9%). A substantial majority, 88.2%, were residents of São Paulo. It isnoteworthy that the patients with neurovascular syndrome included in the study primarily presented with symptomscharacteristic of an influenza-like syndrome (fever and cough in 64% of the cases, dyspnea in 53% of the cases), and none reportedanosmia or hyposmia as a primary complaint initially. Concerning cardiovascular risk factors, the following conditions wereassociated with cerebrovascular events: hypertension was present in 64.7% of cases, diabetes mellitus in 52.9%, active smoking in23.5%, chronic kidney disease in 11.8%, and obesity in 11.8%. Another remarkable observation from the evaluation of the selectedpatients, which has become a common finding in epidemiological studies on strokes and COVID-19, is the high rate of patientsrequiring hospitalization (88.2%). Of these hospitalized individuals, 80% required intensive care unit (ICU) support. In our caseseries, all of these (100%) presented with severe COVID-19 infection, secondary bacterial infection, as well as the necessity formechanical ventilation. Furthermore, of those admitted to the ICU, 73.3% developed acute kidney injury requiring hemodialysis,and a similar proportion succumbed to the illness (73.3%). Conclusion: Based on current evidence, the causal relationship betweencerebrovascular events and COVID-19 remains inconclusive. However, it is important to remain vigilant regarding well-establishedfacts, such as the presence of acute inflammation in response to COVID-19 infection.

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“…[4] There have been concerns that COVID-19 vaccines may cause adverse effects in PWE, particularly an increase in seizures, either directly or through vaccine induced fever, which can reduce seizure threshold. [ 3 , 5 , 6 ] As a result there may be reduced vaccine uptake in PWE. [3] …”

Section: Introductionmentioning

confidence: 99%