Global Learning Strategies for Toxicology Students, Using Ict Tools

Moyano, P.; García, Johana Montoro; Garcia, J.; Naval, María Victoria; Flores, A.; Sanjuan, J.; Guerra, L.; Sola, Emma; Pelayo, A.; Lobo, María Dolores Sanz; Frejo, M.T.; Anadón, M.J.; Pino, Javier del

doi:10.21125/inted.2021.0274

Cited by 1 publication

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“…ROS formation can occur through enzymatic or non-enzymatic reactions when there is an imbalance between prooxidant factors and their elimination. This can be related to the action of endogenous or exogenous factors and can lead to a range of molecular damage 49,50,51,52,53,54,55 . The maintenance of redox homeostasis is promoted by molecules with antioxidant potential, which act in the regulation of ROS production and elimination.…”

Section: Thyroid Morphophysiology: An Overviewmentioning

confidence: 99%

Environmental Endocrinology: Parabens Hazardous Effects on HPT Axis

Azeredo,

Anselmo,

Soares

et al. 2023

Preprint

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Parabens are classified as endocrine disrupting compounds (EDCs), capable of interfering with the normal functioning of the thyroid, affecting the proper regulation of the biosynthesis of thyroid hormones (TH) which is controlled by hypothalamic-pituitary-thyroid axis (HPT). Given the crucial role of these hormones in health and the growing evidence of diseases related to thyroid dysfunction, this review looks at the effects of paraben exposure on the thyroid. In this study, we considered research carried out in vitro, in vivo, and epidemiological studies published between 1951 and 2023, which demonstrated an association between exposure to parabens and dysfunctions of the HPT axis. In humans, exposure to parabens appears to increase thyroid-stimulating hormone (TSH) levels, while in rodents, exposure decreases TSH levels. The effects on HT levels are also poorly described, as well as peripheral metabolism. Regardless, recent studies have shown different actions between different subtypes of parabens on the HPT axis, which allows us to speculate that the mechanism of action of these parabens is different. Furthermore, studies of exposure to parabens are more evident in women than in men. Therefore, future studies are needed to clarify the effects of exposure to parabens and their mechanisms of action on this axis.

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