Global Melanoma Correlations With Obesity, Smoking, and Alcohol Consumption

Batta, Nisha; Shangraw, Sarah; Nicklawsky, Andrew; Yamauchi, Takeshi; Zhai, Zili; Menon, Dinoop Ravindran; Gao, Dexiang; Dellavalle, Robert P.; Fujita, Mayumi

doi:10.2196/31275

Cited by 4 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Researchers investigating the correlation between ALDH2 polymorphism and melanoma have found that the wild-type ALDH2 allele had strong positive correlations with melanoma incidence and mortality. 51 An experimental animal study revealed that melanoma progression and tumor angiogenesis, under the influence of ethanol, is mediated by the upregulation of vascular endothelial growth factor and its receptor Flt-1. 52 Another study found that long-term alcohol consumption inhibited memory T cell proliferation, accelerated interferon-gamma decay in CD8 T cells and increased the percentage of myeloid-derived suppressor cells in the peripheral blood and spleen, which may be associated with melanoma onset, progression, and metastasis.…”

Section: Neoplastic Skin Diseasesmentioning

confidence: 99%

Advances in Relationship Between Alcohol Consumption and Skin Diseases

Liu,

Chen

2023

CCID

View full text Add to dashboard Cite

Throughout history, alcohol consumption has been an integral part of human culture. Alcohol consumption, alcoholism in particular, influences the onset and progression of liver diseases, neurological disorders, and multiple types of cancer. However, the role of alcohol consumption in influencing skin diseases has often been overlooked. In this review, we present the progress of research investigating the effects and potential mechanisms of action of alcohol consumption on acne, rosacea, psoriasis, atopic dermatitis, melanoma, and non-melanoma skin cancer.

show abstract

Section: Neoplastic Skin Diseasesmentioning

confidence: 99%

Advances in Relationship Between Alcohol Consumption and Skin Diseases

Liu,

Chen

2023

CCID

View full text Add to dashboard Cite

show abstract

“…However, the clinical significance of ALDH2 polymorphism in melanoma remains unclear. The ALDH2*2 allele is prevalent in populations with low melanoma incidence, such as Mongolians [161], but rare in high-risk populations like Caucasians with high alcohol consumption [6,161]. Therefore, we analyzed global melanoma data, alcohol consumption, and published ALDH2 information and found that the wild-type ALDH2 allele was strongly positively correlated with melanoma incidence (R = 0.70; p < 0.001), while the allelic variants had a modest to strong negative correlation (R = −0.70; p < 0.001 and R = −0.51; p = 0.01 for ALDH2*1/*2 and ALDH2*2/*2, respectively) [6].…”

Section: Acah Metabolizing Enzymes In Human Melanomamentioning

confidence: 99%

“…Melanoma is the most serious type of skin cancer, with an increasing incidence worldwide [1,2]. Cumulative evidence indicates that the risk of melanoma correlates with genetic factors [3,4], personal lifestyles [5,6], and phenotypic risk factors that reflect gene/personal lifestyle interactions [7,8]. Individual lifestyle factors associated with melanoma risk include UV exposure, cigarette smoking, alcohol use, overweight and obesity, poor diet, environmental pollution, and stress [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Cumulative evidence indicates that the risk of melanoma correlates with genetic factors [3,4], personal lifestyles [5,6], and phenotypic risk factors that reflect gene/personal lifestyle interactions [7,8]. Individual lifestyle factors associated with melanoma risk include UV exposure, cigarette smoking, alcohol use, overweight and obesity, poor diet, environmental pollution, and stress [5,6]. Recently, we summarized epidemiological data on the association between alcohol consumption and cutaneous melanoma [9].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ethanol Metabolism and Melanoma

Zhai

Yamauchi

Shangraw

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

Malignant melanoma is the deadliest form of skin cancer. Despite significant efforts in sun protection education, melanoma incidence is still rising globally, drawing attention to other socioenvironmental risk factors for melanoma. Ethanol and acetaldehyde (AcAH) are ubiquitous in our diets, medicines, alcoholic beverages, and the environment. In the liver, ethanol is primarily oxidized to AcAH, a toxic intermediate capable of inducing tumors by forming adducts with proteins and DNA. Once in the blood, ethanol and AcAH can reach the skin. Although, like the liver, the skin has metabolic mechanisms to detoxify ethanol and AcAH, the risk of ethanol/AcAH-associated skin diseases increases when the metabolic enzymes become dysfunctional in the skin. This review highlights the evidence linking cutaneous ethanol metabolism and melanoma. We summarize various sources of skin ethanol and AcAH and describe how the reduced activity of each alcohol metabolizing enzyme affects the sensitivity threshold to ethanol/AcAH toxicity. Data from the Gene Expression Omnibus database also show that three ethanol metabolizing enzymes (alcohol dehydrogenase 1B, P450 2E1, and catalase) and an AcAH metabolizing enzyme (aldehyde dehydrogenase 2) are significantly reduced in melanoma tissues.

show abstract

“…We also analyzed the World Health Organization (WHO) database globally and reported a strong positive correlation between alcohol consumption amount and melanoma incidence ( R = 0.72; p < 0.001) by plotting each country’s data and calculating spearman’s rank correlation coefficient for melanoma incidence and mortality with alcohol consumption [ 81 ]. Interestingly, the data also revealed a positive correlation between alcohol dose and melanoma mortality ( R = 0.59; p < 0.001).…”

Section: Alcohol and Melanomamentioning

confidence: 99%

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma

Yamauchi

Shangraw²,

Zhai³

et al. 2022

Cancers

View full text Add to dashboard Cite

Although cancer mortality has declined among the general population, the incidence of melanoma continues to rise. While identifying high-risk cohorts with genetic risk factors improves public health initiatives and clinical care management, recognizing modifiable risk factors such as social-environmental risk factors would also affect the methods of patient outreach and education. One major modifiable social-environmental risk factor associated with melanoma is ultraviolet (UV) radiation. However, not all forms of melanoma are correlated with sun exposure or occur in sun-exposed areas. Additionally, UV exposure is rarely associated with tumor progression. Another social-environmental factor, pregnancy, does not explain the sharply increased incidence of melanoma. Recent studies have demonstrated that alcohol consumption is positively linked with an increased risk of cancers, including melanoma. This perspective review paper summarizes epidemiological data correlating melanoma incidence with alcohol consumption, describes the biochemical mechanisms of ethanol metabolism, and discusses how ethanol and ethanol metabolites contribute to human cancer, including melanoma.

show abstract

Global Melanoma Correlations With Obesity, Smoking, and Alcohol Consumption

Cited by 4 publications

References 9 publications

Advances in Relationship Between Alcohol Consumption and Skin Diseases

Advances in Relationship Between Alcohol Consumption and Skin Diseases

Ethanol Metabolism and Melanoma

Alcohol as a Non-UV Social-Environmental Risk Factor for Melanoma

Contact Info

Product

Resources

About