Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives

Schwarz, Peter; Towers, G. Wayne; Merwe, Annelize van der; Perez-Perez, L.; Rheeder, Paul; Schulze, Jan; Bornstein, Stefan R.; Licinio, Júlio; Wong, Ma-Li; Schutte, Aletta E.; Olckers, Antonel

doi:10.1038/tpj.2008.2

Cited by 16 publications

(16 citation statements)

References 48 publications

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“…[9,29]). A meta‐analysis of the initial literature showing diabetes associations with rs17360539 and rs266729 (the most widely investigated upstream variants) suggests an ∼8% increase in diabetes risk among carriers of these variants in European populations [7,8]. The linked variants that we evaluated (rs822387 and rs182052) were associated with adiponectin concentrations but not diabetes incidence in our data set.…”

Section: Discussionmentioning

confidence: 95%

“…Upstream, intronic and 3¢ untranslated region variants in ADIPOQ (the gene encoding the adiponectin protein) are recognized that are significantly related to adiponectin concentrations [2][3][4][5][6]. Although individual study results vary, in meta-analyses these common upstream variants exert modest overall effects on adiponectin concentrations [6][7][8]. Exonic variants with clear functional effects on the adiponectin transcript have also been recognized [3,9].…”

Section: Introductionmentioning

confidence: 99%

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Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program

et al. 2012

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Aims Baseline adiponectin concentrations predict incident Type 2 diabetes mellitus in the Diabetes Prevention Program. We tested the hypothesis that common variants in the genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1, ADIPOR2) would associate with circulating adiponectin concentrations and/or with diabetes incidence in the Diabetes Prevention Program population. Methods Seventy-seven tagging single-nucleotide polymorphisms (SNPs) in ADIPOQ (24), ADIPOR1 (22) and ADIPOR2 (31) were genotyped. Associations of SNPs with baseline adiponectin concentrations were evaluated using linear modelling. Associations of SNPs with diabetes incidence were evaluated using Cox proportional hazards modelling. Results Thirteen of 24 ADIPOQ SNPs were significantly associated with baseline adiponectin concentrations. Multivariable analysis including these 13 SNPs revealed strong independent contributions from rs17366568, rs1648707, rs17373414 and rs1403696 with adiponectin concentrations. However, no ADIPOQ SNPs were directly associated with diabetes incidence. Two ADIPOR1 SNPs (rs1342387 and rs12733285) were associated with ~18% increased diabetes incidence for carriers of the minor allele without differences across treatment groups, and without any relationship with adiponectin concentrations. Conclusions ADIPOQ SNPs are significantly associated with adiponectin concentrations in the Diabetes Prevention Program cohort. This observation extends prior observations from unselected populations of European descent into a broader multi-ethnic population, and confirms the relevance of these variants in an obese/dysglycaemic population. Despite the robust relationship between adiponectin concentrations and diabetes risk in this cohort, variants in ADIPOQ that relate to adiponectin concentrations do not relate to diabetes risk in this population. ADIPOR1 variants exerted significant effects on diabetes risk distinct from any effect of adiponectin concentrations. [Clinical Trials Registry Nos; NCT 00004992 (Diabetes Prevention Program) and NCT 00038727 (Diabetes Prevention Program Outcomes Study)]

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program

et al. 2012

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“…30,35,37,39,44,45 Furthermore, associations of ADIPOQ polymorphisms with type 2 diabetes and coronary artery disease have been reported in some studies. 1,[46][47][48] Thus, this absence of association does not necessarily indicate a lack of effect of ADI-POQ polymorphisms. Both hypertension and dyslipidaemia are highly inheritable characteristics and originate from the interactions of multiple genes, environmental factors and behaviour.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is a lack of consistency among results, some studies reported that the ADIPOQ polymorphisms are associated with plasma adiponectin levels, which may lead to a change in blood lipids and blood pressure 30,35,37,39,44,45 . Furthermore, associations of ADIPOQ polymorphisms with type 2 diabetes and coronary artery disease have been reported in some studies 1,46–48 . Thus, this absence of association does not necessarily indicate a lack of effect of ADIPOQ polymorphisms.…”

Section: Discussionmentioning

confidence: 99%

Genetic effects of adiponectin on blood lipids and blood pressure

Zhao

2011

Clinical Endocrinology

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“…The same group of researchers [31] also showed that Africans with different coping mechanisms had different responses to the handgrip test regarding total peripheral resistance, stroke volume and cardiac output. Furthermore, it is conceivable that the response to the nutrition transition could be influenced by genetic selection and/or epigenetic programming in populations who were previously challenged with survival on low-energy and micronutrient-poor diets, as shown for risk of diabetes in Africans [32,33]. …”

Section: The Determinants Of the Nutrition Transition In Africamentioning

confidence: 99%

The Nutrition Transition in Africa: Can It Be Steered into a More Positive Direction?

2011

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The objective of this narrative review is to examine the nutrition transition and its consequences when populations in Africa modernize as a result of socio-economic development, urbanization, and acculturation. The focus is on the changes in dietary patterns and nutrient intakes during the nutrition transition, the determinants and consequences of these changes as well as possible new approaches in public health nutrition policies, interventions and research needed to steer the nutrition transition into a more positive direction in Africa. The review indicates that non-communicable, nutrition-related diseases have emerged in sub-Saharan Africa at a faster rate and at a lower economic level than in industrialized countries, before the battle against under-nutrition has been won. There is a putative epigenetic link between under- and over-nutrition, explaining the double burden of nutrition-related diseases in Africa. It is concluded that it is possible to steer the nutrition transition into a more positive direction, provided that some basic principles in planning public health promotion strategies, policies and interventions are followed. It is suggested that sub-Saharan African countries join forces to study the nutrition transition and implemented interventions on epidemiological, clinical and molecular (genetic) level for better prevention of both under- and over-nutrition.

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Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives

Cited by 16 publications

References 48 publications

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program

Common variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/2), adiponectin concentrations, and diabetes incidence in the Diabetes Prevention Program

Genetic effects of adiponectin on blood lipids and blood pressure

The Nutrition Transition in Africa: Can It Be Steered into a More Positive Direction?

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