Global Metabolite Profiling Reveals Transformation Pathways and Novel Metabolomic Responses in<i>Solea senegalensis</i>after Exposure to a Non-ionic Surfactant

Álvarez-Muñoz, Diana; Al-Salhi, Raghad; Abdul‐Sada, Alaa; González-Mazo, Eduardo; Hill, Elizabeth M.

doi:10.1021/es501276g

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…Moreover, little knowledge exists on the effects of sub-lethal concentrations of contaminants on aquatic biota and this is where environmental metabolomics could prove very useful. This is important to consider, as exemplified by the study of Álvarez-Muñoz et al. (2014) where LC-HRMS was used to examine the potential effect of alcohol polyethoxylates on Solea senegalensis .…”

Section: Characterising the Exposome With Chromatography And High Resmentioning

confidence: 99%

A review of the pharmaceutical exposome in aquatic fauna

Miller

Bury

Owen

et al. 2018

Environmental Pollution

219

107

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Pharmaceuticals have been considered ‘contaminants of emerging concern’ for more than 20 years. In that time, many laboratory studies have sought to identify hazard and assess risk in the aquatic environment, whilst field studies have searched for targeted candidates and occurrence trends using advanced analytical techniques. However, a lack of a systematic approach to the detection and quantification of pharmaceuticals has provided a fragmented literature of serendipitous approaches. Evaluation of the extent of the risk for the plethora of human and veterinary pharmaceuticals available requires the reliable measurement of trace levels of contaminants across different environmental compartments (water, sediment, biota - of which biota has been largely neglected). The focus on pharmaceutical concentrations in surface waters and other exposure media have therefore limited both the characterisation of the exposome in aquatic wildlife and the understanding of cause and effect relationships. Here, we compile the current analytical approaches and available occurrence and accumulation data in biota to review the current state of research in the field. Our analysis provides evidence in support of the ‘Matthew Effect’ and raises critical questions about the use of targeted analyte lists for biomonitoring. We provide six recommendations to stimulate and improve future research avenues.

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Section: Characterising the Exposome With Chromatography And High Resmentioning

confidence: 99%

A review of the pharmaceutical exposome in aquatic fauna

Miller

Bury

Owen

et al. 2018

Environmental Pollution

219

107

View full text Add to dashboard Cite

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“…Recent improvements in analytical techniques have made it possible to scan thousands of metabolites in a single metabolomics analysis, and this technology has been used to investigate metabolic changes within a biological system in response to toxicant exposure . Various environmental pollutants were observed to disrupt metabolite homeostasis, and changes in metabolic profiles have been assessed as toxicological endpoints to reflect chemical-induced metabolomic perturbations. − For example, laboratory exposure to nonionic surfactants induced pronounced alterations in phospholipid and glucocorticoid concentrations in sole; field exposure to wastewater from treatment plants disrupted prostaglandin biosynthesis in roaches . Such molecule responses could be considered as biomarkers of environmental exposure.…”

Section: Introductionmentioning

confidence: 99%

“…7 Various environmental pollutants were observed to disrupt metabolite homeostasis, and changes in metabolic profiles have been assessed as toxicological endpoints to reflect chemical-induced metabolomic perturbations. 7−10 For example, laboratory exposure to nonionic surfactants induced pronounced alterations in phospholipid and glucocorticoid concentrations in sole; 8 field exposure to wastewater from treatment plants disrupted prostaglandin biosynthesis in roaches. 9 Such molecule responses could be considered as biomarkers of environmental exposure.…”

Section: ■ Introductionmentioning

confidence: 99%

Xenobiotics Targeting Cardiolipin Metabolism to Promote Thrombosis in Zebrafish

Liu

Cui

Huang

et al. 2021

Environ. Sci. Technol.

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Exposure to environmental pollutants is an important factor contributing to the development and severity of thrombosis. However, the important physiological molecules in the thrombotic processes affected by environmental exposures remain unknown. In this study, we show that exposure to environmental chemicals disrupts the equilibrium of cardiolipins (CLs), and directing CL synthesis promotes thrombosis. Using an untargeted metabolomics approach, approximately 3030 molecules were detected in zebrafish embryos exposed to 11 environmental chemicals and automatically clustered into a network. Interconnectivity among CLs and linoleates or isoxanthopterin was discovered through the highly consistent variations in the coregulated metabolites in the network. The chemical exposure resulted in significant upregulation of CLs through influencing the enzymatic activities of phospholipase A2, cardiolipin synthase, and lysocardiolipin acyltransferase. Consequently, metabolic disorders of CLs affected the levels of anticardiolipin antibodies, disrupted the homeostasis between platelet thromboxane A2 and endothelial prostacyclin, and promoted thrombotic events including heart ischemia and tachycardia. Our study thus reveals the common molecular mechanisms underlying the CL-induced thrombosis targeted by environmental exposures.

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“…To this respect, the analysis of enzymatic activities related to xenometabolism and oxidative stress have been commonly used for the characterization of organisms response to different stress factors, including chemical pollution (Vidal-Liñán, 2015). Furthermore, the analysis of organisms metabolome (through a metabolomics approach) has been used in many fields including ecotoxicology, for the evaluation of sub-lethal alterations in organisms exposed to different contaminants, revealing new ecotoxicological effects and postulating biomarkers of exposure (Álvarez-Muñoz et al, 2014;Serra-Compte et al, 2018a).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics

Serra-Compte

Álvarez-Muñoz

Solé

et al. 2019

Environmental Research

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Antibiotics accumulation in aquatic organisms may be of great concern from an ecological point of view but also from a human perspective, especially when they are accumulated in edible animals like marine mussels. In this work, mussels (Mytilus galloprovincialis) were exposed to sulfamethoxazole antibiotic (SMX) at 10 µg/L during 96 h, followed by 24 h of depuration. The experiment was carried out at summer and winter conditions. SMX showed a bioconcentration factor in mussel of 1.5 L/Kg (dry weight) and 69% of the compound was eliminated from the 1 organism in 24 h. The metabolomics approach revealed alterations in amino acids levels (aspartate, phenylalanine, valine and tryptophan) pinpointing disturbances in osmotic regulation and energy metabolism. Besides, the levels of some nucleotides (guanosine and inosine) and a carboxylic acid were also affected. However, SMX exposed mussels did not show any significant alteration in the enzymatic activities related to the xenobiotic metabolism and oxidative stress. Moreover, some of the changes observed in mussel's metabolites suggested alterations in mussel's organoleptic characteristics that can affect its quality as seafood commodity. Overall, our results showed that SMX exposure to marine mussels may have ecological implications by provoking sub-lethal effects to exposed organisms. Nevertheless, no risk for consumers derived from mussel ingestion is expected due to the low bioconcentration capacity of SMX and fast depuration in this seafood type.

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Global Metabolite Profiling Reveals Transformation Pathways and Novel Metabolomic Responses inSolea senegalensisafter Exposure to a Non-ionic Surfactant

Cited by 9 publications

References 45 publications

A review of the pharmaceutical exposome in aquatic fauna

A review of the pharmaceutical exposome in aquatic fauna

Xenobiotics Targeting Cardiolipin Metabolism to Promote Thrombosis in Zebrafish

Comprehensive study of sulfamethoxazole effects in marine mussels: Bioconcentration, enzymatic activities and metabolomics

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