Global modulation in DNA epigenetics during pro-inflammatory macrophage activation

Jain, Nikhil; Shahal, Tamar; Gabrieli, Tslil; Gilat, Noa; Torchinsky, Dmitry; Michaeli, Yael; Vogel, Viola; Ebenstein, Yuval

doi:10.1080/15592294.2019.1638700

Cited by 24 publications

(17 citation statements)

References 52 publications

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“…It is possible that the body of patients protects itself from the negative epigenetic changes in the long term by acute flares of the disease. A study by Jain et al suggested that white blood cells change their epigenome quickly to better suit the threat they are facing [ 56 ]. However possible, the explanation is purely speculative with current state of knowledge.…”

Section: Discussionmentioning

confidence: 99%

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

et al. 2021

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Background Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriatic patients experience accelerated aging. As accelerated aging might be the reason for the higher prevalence of comorbidities at lower chronological ages, we also wanted to investigate the relationship between aging and selected parameters of frequent psoriatic comorbidities - endocan, vascular endothelial growth factor and interleukin-17. Samples were obtained from 28 patients and 42 healthy controls. Epigenetic age measurement was based on the Horvath clock. The levels of endocan, vascular endothelial growth factor and interleukin-17 were analyzed using standardized ELISA methods. Results The difference between the epigenetic age and the chronological age of each individual subject did not increase with the increasing chronological age of patients. We cannot conclude that psoriasis causes accelerated aging. However, the epigenetic and chronological age difference was significantly higher in female patients than in female controls, and the difference was correlated with endocan (r = 0.867, p = 0.0012) and vascular endothelial growth factor (r = 0.633, p = 0.0365) only in female patients. Conclusions The findings suggest a possible presence of pathophysiological processes that occur only in female psoriatic patients. These processes make psoriatic females biologically older and might lead to an increased risk of comorbidity occurrence. This study also supports the idea that autoimmune diseases cause accelerated aging, which should be further explored in the future.

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Section: Discussionmentioning

confidence: 99%

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

et al. 2021

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“…The epigenetic level of regulation is critical for the differentiation and functional programming of macrophages [15,113]. There are three levels of epigenetic control of macrophages differentiation and activation: DNA methylation, histone modifications, and microRNA [15,114].…”

Section: Epigenetic Regulation Of Tamsmentioning

confidence: 99%

“…TET2 expression is increased in intratumoral myeloid cells, both in a mouse model of melanoma and in melanoma patients, that is dependent on an IL-1R-MyD88 pathway [135]. Recently, the combination of mass spectrometry and single molecular imaging demonstrated that LPS induces global changes in DNA methylation of the genome of murine macrophages [113,134]. Table 2.…”

Section: Dna Methylationmentioning

confidence: 99%

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Larionova

Kazakova

Patysheva

et al. 2020

Cancers

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Macrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage programming in tumor microenvironments that act on the transcriptional, epigenetic and metabolic levels. We summarize the latest knowledge on the types of transcriptional factors and epigenetic enzymes that control the direction of macrophage functional polarization and their pro- and anti-tumor activities. We also focus on the major types of metabolic programs of macrophages (glycolysis and fatty acid oxidation), and their interaction with cancer cells and complex TME. We have discussed how the regulation of macrophage polarization on the transcriptional, epigenetic and metabolic levels can be used for the efficient therapeutic manipulation of macrophage functions in cancer.

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“…In individuals with asthma, aberrant differentiation of monocytes is observed, notably characterised by a predominance of CD14+/CD16+ cells in blood, typical of tissue macrophages [76,77]. DNA methylation differs between the subsets of monocyte [78], and its localised remodelling is observed during monocyte differentiation into classically activated (M1) and alternatively activated (M2) macrophages [79,80,81]. More specifically, during monocyte to macrophage differentiation, a specific phagocytic gene network is demethylated by TET enzymes [82].…”

Section: Cell-specific Dna Methylation Modifications Associated Wimentioning

confidence: 99%

Cell-Specific DNA Methylation Signatures in Asthma

Thibeault

Laprise

2019

Genes

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Asthma is a complex trait, often associated with atopy. The genetic contribution has been evidenced by familial occurrence. Genome-wide association studies allowed for associating numerous genes with asthma, as well as identifying new loci that have a minor contribution to its phenotype. Considering the role of environmental exposure on asthma development, an increasing amount of literature has been published on epigenetic modifications associated with this pathology and especially on DNA methylation, in an attempt to better understand its missing heritability. These studies have been conducted in different tissues, but mainly in blood or its peripheral mononuclear cells. However, there is growing evidence that epigenetic changes that occur in one cell type cannot be directly translated into another one. In this review, we compare alterations in DNA methylation from different cells of the immune system and of the respiratory tract. The cell types in which data are obtained influences the global status of alteration of DNA methylation in asthmatic individuals compared to control (an increased or a decreased DNA methylation). Given that several genes were cell-type-specific, there is a great need for comparative studies on DNA methylation from different cells, but from the same individuals in order to better understand the role of epigenetics in asthma pathophysiology.

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Global modulation in DNA epigenetics during pro-inflammatory macrophage activation

Cited by 24 publications

References 52 publications

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Cell-Specific DNA Methylation Signatures in Asthma

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