The Intergovernmental Panel on Climate Change (IPCC) provides regular scientific assessments on climate change, its implications, and potential future risks based on estimated energy matrixes and policy pathways. The aim of this publication is to assess the risks climate change poses to biodiversity using projected IPCC climate scenarios for the period 2081–2100, combined with key species-sensitivity indicators and variables as a response to climate change projections. In doing so, we address how climate-change-driven pressures may affect biodiversity. Additionally, a novel causal relationship between extreme ambient temperature exposure levels and the corresponding effects on individual species, noted in this paper as the Upper Thermal-Tolerance Limit and Species Sensitivity Distribution (UTTL-SSD), provides a compelling explanation of how global warming affects biodiversity. Our study indicates that North American and Oceanian sites with humid continental and subtropical climates, respectively, are poised to realize temperature shifts that have been identified as potential key tipping-point triggers. Heat stress may significantly affect approximately 60–90% of mammals, 50% of birds, and 50% of amphibians in North American and Oceanian sites for durations ranging from 5 to 84 days per year from 2080. In the humid temperate oceanic climate of European sites, the climate conditions remain relatively stable; however, moderate cumulative effects on biodiversity have been identified, and additional biodiversity-assemblage threat profiles exist to represent these. Both the integration of IPCC-IUCN profiles and the UTTL-SSD response relationship for the species communities considered have resulted in the identification of the projected threats that climate pressures may impose under the considered IPCC scenarios, which would result in biodiversity degradation. The UTTL-SSD responses developed can be used to highlight potential breakdowns among trophic levels in food web structures, highlighting an additional critical element when addressing biodiversity and ecosystem concerns.