Global occurrence, bioaccumulation factors and toxic effects of polychlorinated biphenyls in tuna: A review

Xie, Jianhua; Bian, Zhihe; Lin, Tian; Tao, Ling; Wu, Qiang; Chen, Ming

doi:10.1016/j.emcon.2020.11.003

Cited by 13 publications

(6 citation statements)

References 74 publications

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“…This species accounts for the world's second largest tuna fishery with annual landings in excess of 1.25 million pounds (Pecoraro et al, 2018(Pecoraro et al, , 2017. As apex predators they can accumulate high levels of marine pollutants, with the primary concern about these pollutants on their potential transfer to humans who eat the tuna (Choy et al, 2009;Nicklisch et al, 2017aNicklisch et al, , 2017bPulster et al, 2020;Xie et al, 2020). Less understood are the potential impacts of these bioaccumulative pollutants on the tuna themselves.…”

Section: Introductionmentioning

confidence: 99%

“…Persistent environmental chemicals which bioaccumulate in apex marine predators also bind to these transporters, but rather than being effectively eliminated, they can inhibit their function (Nicklisch et al, 2016;Sreeramulu et al, 2007;Xie et al, 2020). Of concern is that the interfering action of these chemicals on xenobiotic metabolism can limit the normal detoxification capacity of XTs.…”

Section: Introductionmentioning

confidence: 99%

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Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares)

Nicklisch

Pouv

Rees

et al. 2021

Comparative Biochemistry and Physiology Part C: Toxicology &

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Marine pollutants bioaccumulate at high trophic levels of marine food webs and are transferred to humans through consumption of apex species. Yellowfin tuna (Thunnus albacares) are marine predators, and one of largest commercial fisheries in the world. Previous studies have shown that yellowfin tuna can accumulate high levels of persistent organic pollutants, including Transporter Interfering Chemicals (TICs), which are chemicals shown to bind to mammalian xenobiotic transporters and interfere with their function. Here, we examined the extent to which these same compounds might interfere with the activity of the yellowfin tuna (Thunnus albacares) ortholog of this transporter. To accomplish this goal we identified, expressed, and functionally assayed tuna ABCB1. The results demonstrated a common mode of vertebrate ABCB1 interaction with TICs that predicts effects across these species, based on high conservation of specific interacting residues. Importantly several TICs showed potent inhibition of Ta-ABCB1, such as the organochlorine pesticides Endrin (EC 50 = 1.2 ± 0.2 μM) and Mirex (EC 50 = 2.3 ± 0.9 μM). However, unlike the effects observed on mouse ABCB1, low concentrations of the organochlorine pesticide TICs p,p'-DDT and its metabolite p,p'-DDD co-stimulated verapamil-induced Ta-ABCB1 ATPase activity possibly suggesting a low transport activity for these ligands in tuna. These results provide a mechanistic basis for understanding the potential vulnerability of tuna to these ubquitous pollutants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares)

Nicklisch

Pouv

Rees

et al. 2021

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…A cross-sectional study found that AA subjects consumed more fish than white subjects [191]. PCBs, known for their high lipophilicity and persistence, tend to bioaccumulate in organisms through the food network, accruing in fish and marine mammals' adipose tissue, where the PCB concentration is thousands of times higher than in water due to the biomagnification process [192]. Leng et al (2016) showed that several PCBs are abundant in both human serum and breast tissue and would increase the risk of BC [164].…”

Section: Endocrine Disruptor Chemicals (Edcs) and Bc Disparitiesmentioning

confidence: 99%

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

Neagu,

Bruno,

Johnson

et al. 2024

IJMS

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Precision oncology is based on deep knowledge of the molecular profile of tumors, allowing for more accurate and personalized therapy for specific groups of patients who are different in disease susceptibility as well as treatment response. Thus, onco-breastomics is able to discover novel biomarkers that have been found to have racial and ethnic differences, among other types of disparities such as chronological or biological age-, sex/gender- or environmental-related ones. Usually, evidence suggests that breast cancer (BC) disparities are due to ethnicity, aging rate, socioeconomic position, environmental or chemical exposures, psycho-social stressors, comorbidities, Western lifestyle, poverty and rurality, or organizational and health care system factors or access. The aim of this review was to deepen the understanding of BC-related disparities, mainly from a biomedical perspective, which includes genomic-based differences, disparities in breast tumor biology and developmental biology, differences in breast tumors’ immune and metabolic landscapes, ecological factors involved in these disparities as well as microbiomics- and metagenomics-based disparities in BC. We can conclude that onco-breastomics, in principle, based on genomics, proteomics, epigenomics, hormonomics, metabolomics and exposomics data, is able to characterize the multiple biological processes and molecular pathways involved in BC disparities, clarifying the differences in incidence, mortality and treatment response for different groups of BC patients.

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“…The bioaccumulative nature of many organic contaminants and their transfer to high trophic level organisms has received substantial attention (Cresson et al, 2016;Corsolini and Sarà, 2017;An et al, 2020;Yu et al, 2020;Won et al, 2020;Xie et al, 2020;Guo et al, 2021). PCBs and PBDEs reach their highest concentrations in marine mammals, which in many cases, have a lower capacity to metabolise organohalogen compounds compared to terrestrial mammals, although this is species dependent (Krahn et al, 2009;Jepson et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The Concentration and Biomagnification of Pcbs and Pbdes Across Four Trophic Levels in a Marine Food Web

Madgett,

Yates,

Webster

et al. 2022

SSRN Journal

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Global occurrence, bioaccumulation factors and toxic effects of polychlorinated biphenyls in tuna: A review

Cited by 13 publications

References 74 publications

Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares)

Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares)

Biological Basis of Breast Cancer-Related Disparities in Precision Oncology Era

The Concentration and Biomagnification of Pcbs and Pbdes Across Four Trophic Levels in a Marine Food Web

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