This article addresses the problem of global practical output tracking by output feedback for a class of uncertain inherently time-varying delay nonlinear systems. Firstly, a homogeneous output-feedback controller is designed for the nominal uncertain inherently system by virtue of adding a power integrator technique. Then, with the help of an appropriate Lyapunov–Krasovskii functional and reduced-order observer, by using the homogeneous domination approach and adding a power integrator method, an output-feedback controller is successfully developed to guarantee all the states of the closed-loop system remain bounded and simultaneously making the tracking error arbitrarily small. The simulation results of an example verify the proposed approach.