Nurses are essential to effective global cancer control, influencing treatment, education, research, and policy issues-at local, national, and international levels. Empowering cancer nurses to lead and take on key leadership roles across the cancer continuum and within different levels of the healthcare system is imperative to addressing the burden of cancer globally. In some countries, addressing inequalities and dismantling professional hierarchies is central to enabling nurses to exercise their leadership capabilities, even if they are not in a leadership role, to improve cancer care outcomes. Although every cancer nurse will be required to demonstrate skills as leaders, not all will be in leadership roles. More nursing leadership roles are needed at national, regional, and global levels. In some countries, more cancer nursing leadership opportunities are provided/available than in others. For example, in many countries, inequalities and professional hierarchies exist, which often prohibit leadership opportunities for cancer nurses. Investment in developing leadership among nurses at all levels is a global priority. 1,2 Leadership is the ability to achieve collaborative effort, enabling people to work together to achieve common goals. It is multifaceted, characterized by the ability to provide and deliver direction and support, motivation, coordination, collaboration, effective communication, and advocacy for patients, communities, and other nurses. Leadership is about interpersonal relationships, and empowering the workforce to be innovative and creative to solve challenges is going to be important moving forward. 3 Strengthening nursing leadership in global health ("no one left behind") is a priority. The consistent messaging in the "Triple Impact Report," 4 the Nursing Now initiative, 5 and in the State of the World's Nursing 6 and the Global Strategic Priorities for Nursing and Midwifery 7 reports is that influential nurse leaders are more critical than ever. As the most significant global health workforce, 8 nursing needs to focus its attention on the development of nurse leaders across clinical care, research, education, policy, and administration if the World Health Organization sustainable development goals 9 and the global strategic priorities for nursing are to be met. The Institute of Medicine report on the Future of Nursing: Leading Change, Advancing Health 10 and more recently the National Academy of Medicine report on the Future of Nursing 2020-2030, 11 both call for nurses to lead interprofessional teams and healthcare systems to benefit patient outcomes and system-level efficiency. Not only has the COVID-19 pandemic powerfully illustrated the knowledge, skills, commitment, and leadership of nurses globally, it has also demonstrated why person-centered, culturally safe, evidence-based care and Universal Health Coverage 12 cannot be achieved without nurses and nurse leaders.Nurses, as informal and formal leaders, need to be fostered and recognized across all aspects and levels of nursing work. Nu...