Rivers in the Lake Victoria Basin support a multitude of ecosystem services, and the economies of the riparian countries (Kenya, Tanzania, Uganda, Rwanda, and Burundi) rely on their discharge, but projections of their future discharges under various climate change scenarios are not available. Here, we apply Vector Autoregressive Moving Average models with eXogenous variables (VARMAX) statistical models to project hydrological discharge for 23 river catchments for the 2015-2100 period, under three representative concentration pathways (RCPs), namely RCPs 2.6, 4.5, and 8.5. We show an intensification of future annual rainfall by 25% in the eastern and 5-10% in the western part of the basin. At higher emission scenarios, the October to December season receives more rainfall than the March to May season. Temperature projections show a substantial increase in the mean annual minimum temperature by 1.3-4.5 • C and warming in the colder season (June to September) by 1.7-2.9 • C under RCP 4.5 and 4.9 • C under RCP 8.5 by 2085. Variability in future river discharge ranges from 5-267%, increases with emission intensity, and is the highest in rivers in the southern and south eastern parts of the basin. The flow trajectories reveal no systematic trends but suggest marked inter-annual variation, primarily in the timing and magnitude of discharge peaks and lows. The projections imply the need for coordinated transboundary river management in the future.is anticipated that climate change will continue to affect river hydrology and ecology through changes in rainfall distribution, soil moisture, river flows, and groundwater levels [11,12]. Recent fluctuations in river levels have had adverse impacts on the social, economic, and environmental well-being of many African communities [13,14]. Major changes in mean river discharge can have devastating impacts, particularly in Africa.Rainfall deficits of between 7% and 29% in East Africa between 1961 to 2010 led to sharp reductions in agricultural output and employment and also resulted in significant losses in Gross Domestic Product (GDP) [15]. Similar economic losses associated with drought conditions have occurred in West Africa, Australia, California, and Southern Africa [16][17][18][19][20]. Such losses emphasize the economic connection of climate and hydrology to water and sanitation, agriculture, fisheries, and energy sectors. Consequently, multiscalar present and future climate change studies are valuable for advancing scientific understanding and providing information for decision making in adaptation and mitigation strategies to deal with widening variability in river flows [21,22].Other threats to freshwater that are exacerbated by climate change include increased river siltation resulting from high soil erosion in the basin, recurrent destructive floods in the low-lying areas, riparian land encroachment, degradation of river banks, eutrophication, and proliferation of the invasive water hyacinth [23,24]. Increasing intensity and frequency of extreme climatic events pose ad...