In recent decades, the building sector has been moving toward promoting renewable raw materials to reduce greenhouse gas emissions associated with construction materials. One of the most valuable alternatives is the use of large-volume fractions of vegetable aggregates, leading to the development of bio-based cement mixture. A review of the recent scientific literature has shown that traditional design rules cannot be applied to bio-based cement mixtures. In this context, this study summarizes the results of a comprehensive experimental campaign aimed at unveiling the influence of bamboo particles on the physical properties and durability indicators of Bamboo Bio-Concrete (BBC) designed by applying a recent methodology proposed by the authors. The mixtures were produced using bamboo particles at a volumetric fraction of 45% and 50%. Fundamental properties such as density, thermal conductivity, capillary water absorption, and drying shrinkage were measured. The results obtained herein highlight the lightweight (density lower than 786 kg/m3) and insulating properties (thermal conductivity within 0.32 to 0.52 W/mK) of the BBC. The capillary absorption ranged between 2.40 and 2.83 g/cm2, whereas the drying shrinkage ranged between 2500 and 5000 µε. These properties indicate the feasibility of using this material in various applications in the construction sector.