2021
DOI: 10.12688/f1000research.27334.2
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Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis

Abstract: Background: This study was conducted to determine the prevalence of headache in coronavirus disease 2019 (COVID-19) and to assess its association as a predictor for COVID-19. This study also aimed to discuss the possible pathogenesis of headache in COVID-19. Methods: Available articles from PubMed, Scopus, and Web of Science were searched as of September 2nd, 2020. Data on characteristics of the study, headache and COVID-19 were extracted following the PRISMA guidelines. Biases were assessed using the Newcastl… Show more

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Cited by 31 publications
(30 citation statements)
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References 183 publications
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“…Data extraction was conducted as explained in previous studies. 23 , 24 , 43 Briefly, important data from the eligible articles were extracted and whenever required supplementary materials were extracted. The list of references was retrieved to search for additional relevant studies.…”
Section: Methodsmentioning
confidence: 99%
“…Data extraction was conducted as explained in previous studies. 23 , 24 , 43 Briefly, important data from the eligible articles were extracted and whenever required supplementary materials were extracted. The list of references was retrieved to search for additional relevant studies.…”
Section: Methodsmentioning
confidence: 99%
“…No speci c mechanisms have been reported on the mechanism of headache in COVID-19 patients. However, a proposal suggests that one of the main pathomechanism of headache in these patients is the activation of trigeminal nerve ending in the periphery followed by the sensitization of various sites in the brain (13). In our study, neurological symptoms were signi cantly associated with severe disease.…”
Section: Discussionmentioning
confidence: 46%
“…Since rst case of COVID-19 reported in Sudan on 13 March 2020 there are more than 38,000 cases in Sudan con rmed with 2,833 deaths and 31,590 recovered cases also more than 8 million case in Africa and more than 226 million cases around the globe until the 17 September 2021 (4, 5).…”
Section: Introductionmentioning
confidence: 99%
“…The 29 nt region found in SL-CoV civets and early stage human strains is also found in SL-CoV bat [91] . Sequence analysis of SARS-CoV-2 has shown a typical structure to other coronavirus and its genome has been linked to a previously identified coronavirus strain, SARS-CoV that caused the SARS outbreak in 2003 [92] .…”
Section: Genome Similarity and Conserved Regionsmentioning
confidence: 79%