Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis

Singh, Prashant; Arora, Ananya; Strand, Tor A.; Leffler, Daniel A.; Catassi, Carlo; Green, Peter H.; Kelly, Ciarán P.; Ahuja, Vineet; Makharia, Govind

doi:10.1016/j.cgh.2017.06.037

Cited by 1,133 publications

(945 citation statements)

References 109 publications

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“…Given this high dropout, future investigations should consider recruiting a larger subject population for follow-up analyses. Furthermore, participants in the developmental stages of the CD-FAB were predominantly female, which reflects the higher prevalence of both eating concerns and CD in females [25, 26]. However, further validation of the CD-FAB should reflect a better balance between males and females.…”

Section: Discussionmentioning

confidence: 99%

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale

Satherley

Howard

Higgs

2018

Gastroenterology Research and Practice

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Objectives Previous studies on coeliac disease suggest that attitudes towards the gluten-free diet may contribute to the development of disordered eating. This study describes the development and validation of the Coeliac Disease Food Attitudes and Behaviours scale (CD-FAB) to measure these behaviours in coeliac disease. Research Methods and Procedures Focus groups were used to develop 33 potential questionnaire items. These items were reviewed by service users and then distributed online to 157 adults with coeliac disease. Items were removed based on ceiling/floor effects, high interitem correlations (>0.7) and factor analysis. 11 items were retained. Exploratory factor analysis was then conducted. The psychometric properties of the final version of the CD-FAB were assessed via using an online platform. Results The CD-FAB had 11 items distributed across one factor assessing attitudes and behaviours towards food. These factors explained 44.1% of the variance in responding. The CD-FAB and its subscales had high internal consistency (Cronbach's alpha > 0.7) and psychometric validation indicated good convergent and discriminant validity. High scores on the CD-FAB are associated with psychological distress and an impaired quality of life. Conclusions The CD-FAB is a reliable and valid measure of food attitudes and behaviours in coeliac disease. As a new disease-specific instrument, it may be a useful tool for evaluating food concerns in individuals with coeliac disease in a clinical setting and for further exploring the development of disordered eating patterns in coeliac disease. Further research is required to assess the full potential of the CD-FAB.

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Section: Discussionmentioning

confidence: 99%

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale

Satherley

Howard

Higgs

2018

Gastroenterology Research and Practice

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“…At present, the global CD prevalence is estimated at approximately 1% with a clear tendency to increase based on data from various locations [15-17]. This lifelong disorder should be identified promptly, but the availability of screening strategies for CD is debatable.…”

Section: Introductionmentioning

confidence: 99%

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Savvateeva

Erdes

Antishin

et al. 2018

Int Arch Allergy Immunol

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Coeliac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten-containing grains in genetically predisposed individuals. Identification of CD in clinical practice is often difficult due to the manifestation of non-specific symptoms and signs, so a relatively significant proportion of CD cases remain undiagnosed. Timely detection of the disease is necessary to provide an appropriate approach to control of the disease treatment, in order to avoid potential complications. This is even more important in the case of children and adolescents, to ensure their proper growth and development. In this review, we discuss the data on the current strategies for CD detection among paediatric populations and the role of questionnaire-based discovery of CD cases in the area of interest. We assume that mass screening is a preferable strategy for finding CD cases within the paediatric population because this could uncover symptomatic, oligosymptomatic, and asymptomatic CD cases. However, under conditions of limited financial resources, screening for CD in risk groups, members of which can be identified using questionnaires, is essential. The pros and cons of CD screening in paediatric populations are presented. These depend on a number of situational criteria (cost-effectiveness, lack of awareness), but screening is designed to improve the detection of the disease and therefore improve the quality of life of patients.

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“…The immune system is triggered by ingestion of gluten from wheat, rye and barley in genetically susceptible individuals [53]. Approximately 1.4% of people worldwide are affected by celiac disease [54]. Nowadays, gluten-free diet (GFD) is the only effective treatment currently available, however, compliance to this dietary therapy is complex.…”

Section: Celiac Diseasementioning

confidence: 99%

Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

et al. 2018

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Abstract:Increasing interest is noticed in the potential of volatile organic compound (VOC) analysis as non-invasive diagnostic biomarker in clinical medical practice. The spectrum of VOCs, originating from (patho)physiological metabolic processes in the human body and detectable in bodily excrements, such as exhaled breath, urine and feces, harbors a magnificent source of information. Thus far, the majority of studies have focused on VOC analysis in exhaled breath, aiming at identification of disease-specific VOC profiles. Recently, an increasing number of studies have evaluated the usability of VOC present in the headspace of feces in the diagnostic work-up of a wide range of gastrointestinal diseases. Promising results have been demonstrated particularly in those diseases in which microbiota alterations are considered to play a significant etiological role, such as colorectal carcinoma, inflammatory bowel disease, irritable bowel syndrome, celiac disease and infectious bowel diseases. In addition, fecal VOC analysis seems to have potential as a diagnostic biomarker for extra-intestinal diseases, including bronchopulmonary dysplasia and sepsis. Different methods for VOC analysis have been used in medical studies, such as gas-chromatography mass spectrometry, selected-ion flow tube-mass spectrometry, ion-mobility spectrometry, and electronic nose devices. In this review, the available literature on the potential of fecal VOCs as diagnostic biomarker, including an overview of relevant VOC detection techniques, is discussed. In addition, future hurdles, which need to be taken prior to implementation of VOC analysis in daily clinical practice, are outlined.

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Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis

Cited by 1,133 publications

References 109 publications

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale

Development and Validation of the Coeliac Disease Food Attitudes and Behaviours Scale

Current Paediatric Coeliac Disease Screening Strategies and Relevance of Questionnaire Survey

Application of Fecal Volatile Organic Compound Analysis in Clinical Practice: Current State and Future Perspectives

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