Global prevalence of dementia: a Delphi consensus study

Ferri, Cleusa P.; Prince, Martin; Brayne, Carol; Brodaty, Henry; Fratiglioni, Laura; Ganguli, Mary; Hall, Kathleen; Hasegawa, Kanae; Hendrie, Hugh C.; Huang, Yueqin; Jorm, Anthony F; Mathers, Colin; Menezes, Paulo Rossi; Rimmer, Elizabeth; Scazufca, Márcia

doi:10.1016/s0140-6736(05)67889-0

Cited by 4,662 publications

(3,409 citation statements)

References 23 publications

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“…Moreover, we have to underline that the comprehensive geriatric assessment we performed also considered objective determinants of the Only about 11% of our sample of depressed older adults were attending a DC. This seems to be a low rate of attendance, yet if we compare it with the rate of attendance of DCs (both regular and specific DCs) in all communitydwelling subjects with dementia (28%) (Georges et al 2008), we believe we have found results of a reasonable magnitude taking into account that: (i) dementia and depression have a similar prevalence in the communitydwelling older population (Ferri et al 2005;Unutzer 2007),…”

Section: Discussionmentioning

confidence: 85%

Day care centre attendance and quality of life in depressed older adults living in the community

et al. 2010

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Late-life depression is associated with disabled functioning and a poor quality of life (QOL). The aim of this cross-sectional study was to find out whether the attendance of a day care centre (DC) was associated with QOL in community-dwelling older adults suffering from a depressive disorder without dementia. The study enrolled 149 depressed older adults aged 70 or older, who consecutively underwent a comprehensive geriatric assessment from April to July 2008 at the Geriatric Medicine Unit of the Fondazione Ospedale Maggiore Policlinico in Milan, Italy. QOL was evaluated by means of the European Quality of Life Visual Analogue Scale (EuroQol VAS). DC attendance was quantified as number of days of attendance per week in the past month. Participants attending a DC at least once a week (n = 17) had a higher mean EuroQol VAS score than non-attendants (n = 132) (mean ± SD 58.8 ± 19 vs. 45.3 ± 22.5; P = 0.019). In multiple linear regression analysis a higher weekly attendance of DCs was related to a better quality of life according to the EuroQol VAS score (unstandardized coefficient 3.048, 95% CI 0.063-6.033, P = 0.045) after correction for age, sex, balance and gait abilities, comorbidity, pharmacotherapy, living alone, and severity of depression. Therefore, in older outpatients suffering from a depressive disorder without dementia the attendance of a DC was an independent correlate of the QOL. A randomized controlled longitudinal study will be necessary to determine whether attending a DC is really effective on the QOL in the management of late-life depression.

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Section: Discussionmentioning

confidence: 85%

Day care centre attendance and quality of life in depressed older adults living in the community

et al. 2010

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“…Finally, most studies investigating the effect of smoking on dementia were conducted with Western populations,13, 17 with relatively few studies conducted in Asia. As there are differences in prevalence18 and type distribution19 of dementia among Western and Asian populations, the effect of smoking on the risk of dementia might also differ between ethnic groups. Therefore, we aimed to investigate the effect of smoking habit change on the risk of developing dementia in this population‐based study using the Korean National Health Insurance System – National Health Screening Cohort (NHIS‐HealS).…”

Section: Introductionmentioning

confidence: 99%

Effect of smoking cessation on the risk of dementia: a longitudinal study

Choi

Park

2018

Ann Clin Transl Neurol

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ObjectiveTo determine the risk of developing dementia in relation to duration of smoking cessation by using a nationwide health claims database.MethodsThis cohort study included 46,140 men aged 60 years or older from Korean National Health Insurance System – National Health Screening Cohort, a population‐based national health screening program from 2002 to 2013. The changes in smoking habit from a questionnaire during the first (2002 and 2003) and second (2004 and 2005) health examination periods, participants were divided into continual smokers, short‐term (less than 4 years) quitters, long‐term (4 years or more) quitters, and never smokers. Participants were followed‐up for 8 years from January 1, 2006 for the development of overall dementia, Alzheimer's disease, and vascular dementia.ResultsCompared to continual smokers, long‐term quitters and never smokers had decreased risk of overall dementia (hazard ratio, HR 0.86 95% CI, confidence interval 0.75–0.99 and HR: 0.81; 95% CI: 0.71–0.91, respectively). Never smokers had decreased risk of Alzheimer's disease (HR: 0.82; 95% CI: 0.70–0.96) compared to continual smokers. Finally, both long‐term quitters (HR: 0.68; 95% CI: 0.48–0.96) and never smokers (HR: 0.71; 95% CI: 0.54–0.95) had decreased risk of vascular dementia compared to continual smokers.InterpretationSmoking was associated with increased risk of dementia. Smokers who quit for a prolonged period of time may benefit from reduced risk of dementia. Therefore, smokers should be encouraged to quit in order to reduce the risk of developing dementia, especially in the elderly population who are already at risk.

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“…In 2010, the World Health Organization estimated the number of persons with AD-related dementia at 35.6 million, which is expected to triple by 2050 to over 115 million [1]. The projected number of persons with AD in the USA by 2050 is 13.5 million, and the medical costs will exceed $20 trillion over the next 40 years [2,3]. The measurable socioeconomic annual costs of the disease on a global scale were estimated to exceed $600 billion in 2010 [1,4].…”

Section: Introductionmentioning

confidence: 99%

Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities

2015

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Alzheimer's disease (AD) has a complex and progressive neurodegenerative phenotype, with hypometabolism and impaired mitochondrial bioenergetics among the earliest pathogenic events. Bioenergetic deficits are well documented in preclinical models of mammalian aging and AD, emerge early in the prodromal phase of AD, and in those at risk for AD. This review discusses the importance of early therapeutic intervention during the prodromal stage that precedes irreversible degeneration in AD. Mechanisms of action for current mitochondrial and bioenergetic therapeutics for AD broadly fall into the following categories: 1) glucose metabolism and substrate supply; 2) mitochondrial enhancers to potentiate energy production; 3) antioxidants to scavenge reactive oxygen species and reduce oxidative damage; 4) candidates that target apoptotic and mitophagy pathways to either remove damaged mitochondria or prevent neuronal death. Thus far, mitochondrial therapeutic strategies have shown promise at the preclinical stage but have had little-to-no success in clinical trials. Lessons learned from preclinical and clinical therapeutic studies are discussed. Understanding the bioenergetic adaptations that occur during aging and AD led us to focus on a systems biology approach that targets the bioenergetic system rather than a single component of this system. Bioenergetic system-level therapeutics personalized to bioenergetic phenotype would target bioenergetic deficits across the prodromal and clinical stages to prevent and delay progression of AD.

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Global prevalence of dementia: a Delphi consensus study

Abstract: We believe that the detailed estimates in this paper constitute the best currently available basis for policymaking, planning, and allocation of health and welfare resources.

Cited by 4,662 publications

References 23 publications

Day care centre attendance and quality of life in depressed older adults living in the community

Day care centre attendance and quality of life in depressed older adults living in the community

Effect of smoking cessation on the risk of dementia: a longitudinal study

Targeting the Prodromal Stage of Alzheimer's Disease: Bioenergetic and Mitochondrial Opportunities

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