Global prevalence of drug-resistant tuberculosis: a systematic review and meta-analysis

Abstract

Background Tuberculosis is a bacterial infectious disease, which affects different parts of a human body, mainly lungs and can lead to the patient’s death. The aim of this study is to investigate the global prevalence of drug-resistant tuberculosis using a systematic review and meta-analysis. Methods In this study, the PubMed, Scopus, Web of Science, Embase, ScienceDirect and Google Scholar repositories were systematically searched to find studies reporting the global prevalence of drug-resistant tuberculosis. The search did not entail a lower time limit, and articles published up until August 2022 were considered. Random effects model was used to perform the analysis. The heterogeneity of the studies was examined with the I2 test. Data analysis was conducted within the Comprehensive Meta-Analysis software. Results In the review of 148 studies with a sample size of 318,430 people, the I2 index showed high heterogeneity (I2 = 99.6), and accordingly random effects method was used to analyze the results. Publication bias was also examined using the Begg and Mazumdar correlation test which indicated the existence of publication bias in the studies (P = 0.008). According to our meta-analysis, the global pooled prevalence of multi-drug resistant TB is 11.6% (95% CI: 9.1–14.5%). Conclusions The global prevalence of drug-resistant tuberculosis was found to be very high, thus health authorities should consider ways to control and manage the disease to prevent a wider spread of tuberculosis and potentially subsequent deaths.

Prevalence of Drug-Resistant Tuberculosis in HIV-Positive and Diabetic Patients in Sinaloa, Mexico: A Retrospective Cross-Sectional Study

“…Kampala City, Uganda, reported an increased TB prevalence of 7% [ 26 ]; the DR to RIF and isoniazid ratio was 14.25% in Ethiopia, suggesting an increase compared with previous reports [ 27 ]. Additionally, epidemiological reports estimated a 11.6% global prevalence of DR-TB, alerting authorities to a wider spread of TB and a potential risk of an increase in mortality [ 28 ].…”

“…This can be explained by the fact that developing countries may not have the necessary resources to offer appropriate treatment and follow-up care, which can lead to patients abandoning treatment [ 28 ].…”

Tendência temporal da avaliação do manejo adequado para diagnóstico e tratamento da tuberculose na atenção primária à saúde no Brasil entre 2012-2018

“…A análise da série histórica dos desfechos de TB multidroga resistente e resistente à rifampicina, de 2010 a 2019, no Brasil, demonstra preocupação, uma vez que o percentual de tratamento completo teve uma queda de 16,3% e o abandono ao tratamento aumentou 7,8% 10 . No cenário mundial, o aumento da carga de TB resistente a medicamentos entre 2020 e 2021 é alarmante, com aproximadamente 450 mil novos casos 2 e uma estimativa de prevalência global combinada de 11,6% 11 .…”

Studying the mechanism of action of new derivatives of quinoxalin-1,4-dioxide on the model organism Mycobacterium smegmatis

“…Туберкулез с множественной лекарственной устойчивостью (МЛУ) по-прежнему остается одной из основных угроз современной медициныc 2018 по 2021 г. произошло 649 000 новых случаев туберкулеза с устойчивостью к рифампицину (RR-TB) -самому эффективному препарату первой линии, из которых в 78 % случаев возникла МЛУ (устойчивость к рифампицину и изониазиду) [1]. Возникновение штаммов с МЛУ может в том числе являться следствием недостаточной приверженности курсу лечения пациентов, прерванной терапии или неправильно подобранного курса химиотерапии.…”