Global prevalence of hidradenitis suppurativa and geographical variation—systematic review and meta-analysis

Phan, Kevin; Charlton, Olivia; Smith, Saxon D

doi:10.1186/s41702-019-0052-0

Cited by 47 publications

(45 citation statements)

References 31 publications

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“…The data demonstrated a lower prevalence in males compared to females in Europe (OR 0.635, 95% CI 0.397–1.1015, P = 0.08), but statistical significance was not reached. Finally, there was no difference in prevalence rates in males versus females in the Asia-Pacific region (OR 0.936, 95% CI 0.319–2.751, P = 0.78) 9 .…”

Section: Epidemiologymentioning

confidence: 79%

The most recent advances in understanding and managing hidradenitis suppurativa

2020

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Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. HS has a significant negative impact on both the quality of life (QOL) of patients affected by this disease as well as family members and caregivers. However, the pathogenesis of HS is multifactorial and still remains to be fully elucidated, which makes the development of treatments difficult. The last 10 years have seen a surge in HS research, and many new findings have come to light, yet much more remains to be elucidated. Physicians must employ a multidisciplinary approach to maximally address all facets of HS. Clinical characteristics of the disease that differ between females and males as well as across different races and ethnic groups must be considered. Targeted topical, oral, and injectable therapies continue to be developed for HS as a greater understanding of the pathogenesis is reached. However, randomized controlled trials regarding dietary factors that may contribute to HS are needed to meet our patients’ growing concerns and questions about the role of diet in HS pathogenesis. Finally, improved outcome measures are needed to standardize HS severity and grading between physicians and clinical trials, and a more diverse representation of HS populations is needed in clinical trials.

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Section: Epidemiologymentioning

confidence: 79%

The most recent advances in understanding and managing hidradenitis suppurativa

2020

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“…Another chronic cutaneous IMID is hidradenitis suppurativa, with a global prevalence of 0.3% [ 245 ]. HS is characterized by occlusion of the apocrine glands, though it is also commonly known as acne inversa, as it occurs in the inverse areas such as the axillae, inframammary regions, groin, and genital and perianal regions.…”

Section: Hidradenitis Suppurativa (Hs)mentioning

confidence: 99%

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

et al. 2021

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The microbiome plays an important role in a wide variety of skin disorders. Not only is the skin microbiome altered, but also surprisingly many skin diseases are accompanied by an altered gut microbiome. The microbiome is a key regulator for the immune system, as it aims to maintain homeostasis by communicating with tissues and organs in a bidirectional manner. Hence, dysbiosis in the skin and/or gut microbiome is associated with an altered immune response, promoting the development of skin diseases, such as atopic dermatitis, psoriasis, acne vulgaris, dandruff, and even skin cancer. Here, we focus on the associations between the microbiome, diet, metabolites, and immune responses in skin pathologies. This review describes an exhaustive list of common skin conditions with associated dysbiosis in the skin microbiome as well as the current body of evidence on gut microbiome dysbiosis, dietary links, and their interplay with skin conditions. An enhanced understanding of the local skin and gut microbiome including the underlying mechanisms is necessary to shed light on the microbial involvement in human skin diseases and to develop new therapeutic approaches.

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“…Hidradenitis suppurativa (HS) is an inflammatory chronic condition characterized by profound inflamed nodules, abscess and sinus tracts, that may ultimately result in fibrosis and scarring, mainly affecting the inguinal axillary and submammary areas of the skin [ 38 ]. Despite its relative high prevalence (5–400:100.000) in the European population [ 39 ], very often HS is not easily identified by clinicians, thus, leading to an alarming diagnostic delay of seven years [ 40 ].…”

Section: Autoinflammatory Diseases With Notch Pathway Involvementmentioning

confidence: 99%

Notch Signaling Regulation in Autoinflammatory Diseases

Gratton

Tricarico

D’Adamo

et al. 2020

IJMS

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Notch pathway is a highly conserved intracellular signaling route that modulates a vast variety of cellular processes including proliferation, differentiation, migration, cell fate and death. Recently, the presence of a strict crosstalk between Notch signaling and inflammation has been described, although the precise molecular mechanisms underlying this interplay have not yet been fully unravelled. Disruptions in Notch cascade, due both to direct mutations and/or to an altered regulation in the core components of Notch signaling, might lead to hypo- or hyperactivation of Notch target genes and signaling molecules, ultimately contributing to the onset of autoinflammatory diseases. To date, alterations in Notch signaling have been reported as associated with three autoinflammatory disorders, therefore, suggesting a possible role of Notch in the pathogenesis of the following diseases: hidradenitis suppurativa (HS), Behçet disease (BD), and giant cell arteritis (GCA). In this review, we aim at better characterizing the interplay between Notch and autoinflammatory diseases, trying to identify the role of this signaling route in the context of these disorders.

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Global prevalence of hidradenitis suppurativa and geographical variation—systematic review and meta-analysis

Cited by 47 publications

References 31 publications

The most recent advances in understanding and managing hidradenitis suppurativa

The most recent advances in understanding and managing hidradenitis suppurativa

Gut–Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions

Notch Signaling Regulation in Autoinflammatory Diseases

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