Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis

Mariz, Bruno Augusto Linhares Almeida; Kowalski, Luiz Paulo; William, William Nassib; Castro, Gilberto de; Chaves, Aline Lauda Freitas; Santos, Marcos André Moura dos; Oliveira, Thiago Bueno; Araujo, André; Normando, Ana Gabriela Costa; Ribeiro, Ana Carolina Prado; Brandão, Thaís Bianca; Vargas, Pablo Agustı́n; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger; Cancer, Neck

doi:10.1016/j.critrevonc.2020.103116

Cited by 42 publications

(42 citation statements)

References 49 publications

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“…One of the reasons for the latter is the diversity of methodical approaches to detect HPV-positive, specifically HPV-driven cases as described in Section 3 . Another aspect is the still not fully understood diversity in HPV prevalence rates in head and neck cancers in various populations tested throughout the world [ 13 , 61 ]. The patients’ smoking habit possibly is one major factor responsible for the geographic impact on HPV prevalence rates since it is well established that patients with HPV-positive and HPV-negative cancers predominantly are non-smokers and smokers, respectively [ 13 , 15 , 16 ].…”

Section: Epidemiologymentioning

confidence: 99%

“…Indeed, the OPSCC HPV prevalence rate in the USA and Sweden is estimated to be approx. 60 and 70%, respectively [ 61 ]. In the USA and Sweden, the proportions of smokers in the general population, with reported 14% (Centers for Disease Control and Prevention, 2019) and 7%, respectively, are low ( , access data: 30 May 2021).…”

Section: Epidemiologymentioning

confidence: 99%

“…40% in OPSCC. A recent meta-analysis on the global prevalence of HPV-driven OPSCC, following the ASCO guidelines [ 61 ], describe a pooled global prevalence of HPV-driven OPSCC of 45% with the highest rates in New Zealand (75%, proportion of smokers 2018: 13%, trend declining [ , access data: 30 May 2021]) and the lowest rates in Brazil (11%). However, the alignment of various global HPV prevalence rates to official public governmental statistics on the burden of smokers in the population as performed above should not be conducted carelessly, since the proportion of smokers in the entire population might significantly differ from the proportion of smokers in the studies themselves.…”

Section: Epidemiologymentioning

confidence: 99%

See 2 more Smart Citations

Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Hoffmann

Quabius

2021

Viruses

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Human papillomaviruses (HPV) cause a subset of head and neck cancers (HNSCC). HPV16 predominantly signs responsible for approximately 10% of all HNSCC and over 50% of tonsillar [T]SCCs. Prevalence rates depend on several factors, such as the geographical region where patients live, possibly due to different social and sexual habits. Smoking plays an important role, with non-smoking patients being mostly HPV-positive and smokers being mostly HPV-negative. This is of unparalleled clinical relevance, as the outcome of (non-smoking) HPV-positive patients is significantly better, albeit with standard and not with de-escalated therapies. The results of the first prospective de-escalation studies have dampened hopes that similar superior survival can be achieved with de-escalated therapy. In this context, it is important to note that the inclusion of p16INK4A (a surrogate marker for HPV-positivity) in the 8th TMN-classification has only prognostic, not therapeutic, intent. To avoid misclassification, highest precision in determining HPV-status is of utmost importance. Whenever possible, PCR-based methods, still referred to as the "gold standard”, should be used. New diagnostic antibodies represent some hope, e.g., to detect primaries and recurrences early. Prophylactic HPV vaccination should lead to a decline in HPV-driven HNSCC as well. This review discusses the above aspects in detail.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Hoffmann

Quabius

2021

Viruses

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“…2 7 Globally, the exact prevalence and distribution of HPV in OSSC specifically is uncertain and needs to be determined as its incidence in HNC reportedly varies by geographical location. Cases of HPV-related OSSC are reportedly increasing in the USA, Europe and South-Central Asian countries, 4 but little is known about the burden and impact of the disease on the African continent. 8 In the African context, the proportion of patients with HPV-positive disease is hard to estimate, as many referral centres do not have access to routine testing.…”

Section: Open Accessmentioning

confidence: 99%

“…Patients with HPV+tumours present at a younger age and are less likely to partake in excessive smoking and alcohol use. [2][3][4] Although the annual incidence of smokingrelated head and neck squamous cell carcinoma's (HNSCC) has decreased significantly over the recent decade at a rate of 1,85% annually, HPV-associated HNSCC incidence has increased significantly at a rate 0.8% annually. 3 Context for this review HPV belongs to a family of viruses that is sexually transmitted.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and distribution of HPV infection and subtypes in oral squamous cell carcinoma in Africa: a systematic review protocol

Holmes

Adeola

et al. 2021

BMJ Open

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IntroductionHuman papillomavirus (HPV) is an established risk factor for oropharyngeal squamous cell carcinoma, regardless of a history of other known risk factors such as alcohol and tobacco. While cases of HPV-related oral squamous cell carcinoma (OSSC) are increasing in the USA, Europe and South Central Asian countries, little is known about the impact of the disease on the African continent.Methods and analysisWe describe a protocol for a systematic review to synthesise the best current evidence to assess the disease burden in Africa. Electronic databases including EBSCOhost, MEDLINE, CINAHL, ACADEMIC SEARCH COMPLETE, ScienceDirect, Web of Science, Scopus, SciCENTRAL, Cochrane Library, International Prospective Register of Systematic Reviews) and WorldCAT will be comprehensively searched for studies reporting on the defined outcomes, in Africa, published from 1985 (when HPV was first reported) to the latest current entries, with no language restriction. Supplemental handsearching of grey literature, conference abstract proceedings, reference lists of included studies and citations in Google Scholar will be conducted. Authors will be contacted, where necessary, to assist with missing data. A customised data extraction form, with specified criteria, will be used for data extraction. Overall study quality assessment will be done using an appropriate risk of bias tool suited to the study design. Where available, qualitative data from studies reporting on the outcomes will be captured on the data extraction form. Using Stata software, we will apply the random-effects meta-analysis model to aggregate prevalence estimates with 95% CI, incorporating the Freeman-Tukey transformation to account for between-study variability. A narrative report of the findings will be presented where data are insufficient in terms of the outcome/s. Subgroup analysis will be done subject to sufficient available data.Ethics and disseminationEthics approval or written consent is not required as the review will be conducted using published data. The findings will be distributed through a peer-review publication and conference presentation.

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Global Burden, Risk factors and Pathobiology of Malignant Neoplasms of the Oral Mucosa and the Oropharynx

Hankinson,

Khurram

2024

Pathological Basis of Oral and Maxillofacial Diseases

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Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis

Cited by 42 publications

References 49 publications

Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Relevance of Human Papillomaviruses in Head and Neck Cancer—What Remains in 2021 from a Clinician’s Point of View?

Prevalence and distribution of HPV infection and subtypes in oral squamous cell carcinoma in Africa: a systematic review protocol

Global Burden, Risk factors and Pathobiology of Malignant Neoplasms of the Oral Mucosa and the Oropharynx

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