Global prevalence of post-COVID-19 sleep disturbances in adults at different follow-up time points: A systematic review and meta-analysis

Linh, Tran Thanh Duy; Ho, Dang Khanh Ngan; Nguyen, Nam Nhat; Hu, Chien Ming; Yang, Chih‐Hao; Wu, Dean

doi:10.1016/j.smrv.2023.101833

Cited by 15 publications

(6 citation statements)

References 68 publications

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“…Although all groups in our analysis recovered their pre-infection sleep duration within 6 months after infection, some participants continued to report long COVID with sleep problems after this period. There is substantial evidence on sleep disturbances after COVID-19, 2,40 with an estimated prevalence of 25% after 12 months, 2 increasing to 50% among people hospitalised with COVID-19. 41 Some facets of sleep health may therefore continue to be affected once pre-infection sleep duration has been recuperated, and further research is needed to better understand how longer-term sleep problems manifest in long COVID.…”

Section: Discussionmentioning

confidence: 99%

“…Long COVID, which describes the post-acute sequelae of SARS-CoV-2 infection, is estimated to affect at least 10% of people who are infected. 1 One of the most common symptoms of long COVID is poor sleep quality, which is reported by an estimated 45% of COVID-19 survivors, 2 with higher prevalence among those with severe disease. 3 However, different timings of assessment across studies and infrequent follow-up has made it difficult to track the trajectory of sleep after infection, 4 with the majority of data only covering the first 6 months after infection.…”

Section: Introductionmentioning

confidence: 99%

“…3 However, different timings of assessment across studies and infrequent follow-up has made it difficult to track the trajectory of sleep after infection, 4 with the majority of data only covering the first 6 months after infection. 2 Additionally, few studies have factored in pre-infection sleep, 2,5 and those that do often rely on retrospectively collected data, which is subject to recall bias and can be unreliable. 6 The situation is further complicated by the economic and public health restrictions present during the COVID-19 pandemic, during which stress, restrictions to movement, loss of morning commutes, and changes to employment are likely to have increased or decreased sleep duration and quality at different timepoints, independently of infection.…”

Section: Introductionmentioning

confidence: 99%

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Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study

Vivaldi,

Talaei,

Blaikley

et al. 2024

Preprint

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Summary Background: Studies into the bidirectional relationship between sleep and long COVID have been limited by retrospective pre-infection sleep data and infrequent post-infection follow-up. We therefore used prospectively collected monthly data to evaluate how pre-infection sleep characteristics affect risk of long COVID, and to track changes in sleep duration during the year after SARS-CoV-2 infection. Methods: COVIDENCE UK is a prospective, population-based UK study of COVID-19 in adults. We included non-hospitalised participants with evidence of SARS-CoV-2 infection, and estimated odds ratios (ORs) for the association between pre-infection sleep characteristics and long COVID using logistic regression, adjusting for potential confounders. We assessed changes in sleep duration after infection using multilevel mixed models. We defined long COVID as unresolved symptoms at least 12 weeks after infection. We defined sleep quality according to age-dependent combinations of sleep duration and efficiency. COVIDENCE UK is registered with ClinicalTrials.gov,NCT04330599. Findings: We included 3994 participants in our long COVID risk analysis, of whom 327 (8.2%) reported long COVID. We found an inverse relationship between pre-infection sleep quality and risk of long COVID (medium vs good quality: OR 1.37[95% CI 1.04-1.81]; medium–low vs good: 1.55 [1.12-2.16]; low vs good: 1.94 [1.11–3.38]). Greater variability in pre-infection sleep efficiency was also associated with long COVID (OR per percentage-point increase 1.06 [1.01–1.11]). We assessed post-infection sleep duration in 6860 participants, observing a 0.11 h (95% CI 0.08–0.13) increase in the first month after infection compared with pre-infection, with larger increases for more severe infections. After 1 month, sleep duration largely returned to pre-infection levels, although fluctuations in duration lasted up to 6 months after infection among people reporting long COVID. Interpretation: Our findings highlight the bidirectional relationship between sleep and long COVID. While poor-quality sleep before SARS-CoV-2 infection associates with increased risk of long COVID thereafter, changes in sleep duration after infection in these non-hospitalised cases were modest and generally quick to resolve.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study

Vivaldi,

Talaei,

Blaikley

et al. 2024

Preprint

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“… 5 Sleep disturbances can occur for less than 3 months to more than 12 months following an acute infection. 6 Understanding the difference in time-frame is essential to comprehend the symptom progression following COVID-19 infection since different definitions of sleep disturbance possess different underlying processes that require different management. 6 A global prevalence meta-analysis study, based on sleep questionnaires, found that the most frequent types of sleep disturbance were poor sleep quality, excessive daytime sleepiness (EDS), insomnia, and sleep apnea.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Post-COVID-19 Conditions on Sleep and Quality of Life in Indonesia: A Nationwide Cross-Sectional Study

Budikayanti,

Hakim,

Mutiani

et al. 2024

NSS

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“…5 The growing prevalence of mood disorders can help precipitate or worsen insomnia, 2,3 which sharply increased with the COVID-19 pandemic, as confirmed by various publications. [6][7][8][9][10] Precipitating and perpetuating factors encompass neurobiological sleep mechanisms, including homeostatic mechanisms, biological time controllers (circadian rhythm), and the flip-flop (switch) control model of the mechanisms in neuronal cell group centers that promote sleep and wakefulness. Thus, insomnia can be understood as a lack of control between sleep-inducing mechanisms and wake-inducing mechanisms (wakefulness), with a hyperactive alert system, hypoactive sleep system, or both simultaneously.…”

Section: Introductionmentioning

confidence: 99%

2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults – Brazilian Sleep Association

Drager,

Assis,

Bacelar

et al. 2023

Sleep Sci

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Chronic insomnia disorder (simplified in this document as insomnia) is an increasingly common clinical condition in society and a frequent complaint at the offices of different areas of health practice (particularly Medicine and Psychology). This scenario has been accompanied by a significant evolution in treatment, as well as challenges in approaching patients in an appropriately way. This clinical guideline, coordinated by the Brazilian Sleep Association and the Brazilian Association of Sleep Medicine and counting on the active participation of various specialists in the area, encompasses an update on the diagnosis and treatment of insomnia in adults. To this end, it followed a structured methodology. Topics of interest related to diagnosis were written based on theoretical framework, evidence in the literature, and professional experience. As for the topics related to the treatment of insomnia, a series of questions were developed based on the PICO acronym (P – Patient, problem, or population; I – Intervention; C – Comparison, control, or comparator; O – Outcome). The work groups defined the eligible options within each of these parameters. Regarding pharmacological interventions, only the ones currently available in Brazil or possibly becoming available in the upcoming years were considered eligible. Systematic reviews were conducted to help prepare the texts and define the level of evidence for each intervention. The final result is an objective and practical document providing recommendations with the best scientific support available to professionals involved in the management of insomnia.

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Global prevalence of post-COVID-19 sleep disturbances in adults at different follow-up time points: A systematic review and meta-analysis

Cited by 15 publications

References 68 publications

Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study

Bidirectional relationship between sleep problems and long COVID: a longitudinal analysis of data from the COVIDENCE UK study

The Impact of Post-COVID-19 Conditions on Sleep and Quality of Life in Indonesia: A Nationwide Cross-Sectional Study

2023 Guidelines on the Diagnosis and Treatment of Insomnia in Adults – Brazilian Sleep Association

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