Global prevalence of sleep disorders during menopause: a meta-analysis

Salari, Nader; Hasheminezhad, Razie; Hosseinian-Far, Amin; Rasoulpoor, Shabnam; Assefi, Marjan; Nankali, Sohila; Nankali, Anisodowleh; Mohammadi, Masoud

doi:10.1007/s11325-023-02793-5

Cited by 18 publications

(6 citation statements)

References 55 publications

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“…2,3,5,24,25 Up to 69% of midlife women report sleep disturbance; however, the proportion of women meeting the criteria for an insomnia diagnosis is much lower (typically between 4% and 40%). [26][27][28][29][30][31][32] There may therefore be a population of women who present to the clinic experiencing sleep disturbance associated with the menopause which does not meet the clinical criteria for a diagnosis of insomnia disorder or other primary sleep disorders. Sleep disturbance associated with the menopause may remain undiagnosed and untreated in many women or, if recognized, be treated using conventional approaches that do not address the unique nature of sleep disturbance in periand postmenopausal women.…”

Section: Discussion/observations Clinical Presentation Of Sleep Distu...mentioning

confidence: 99%

Sleep disturbance associated with the menopause

Maki,

Panay,

Simon

2024

Menopause

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Importance and objectives Sleep disturbance is one of the most common and debilitating symptoms experienced by women during the menopause transition. However, there are currently no therapies specifically approved for sleep disturbance associated with the menopause. Here, we consider how to characterize sleep disturbance associated with the menopause and discuss its etiology, including the latest advances in our understanding of the neuronal circuits that regulate reproduction, body temperature, sleep, and mood; and reflect on its impact on women's health and well-being. We also examine the current treatment landscape and look to the future of treatment for this condition. Methods We conducted a review of the literature and combined this with discussion with experts in the fields of sleep and menopause as well as experiences from our own clinical practices. Discussion and conclusions Sleep disturbance associated with the menopause is characterized by frequent night-time awakenings and increased awake time after sleep onset. Its impacts are wide-ranging, negatively affecting health as well as personal and social relationships, productivity, and work performance. There is currently an unmet need for effective, safe, and well-tolerated treatments to address this important symptom, and wider recognition of the association between sleep disturbances and the menopause is needed. Sleep disturbances associated with the menopause can result from hormone changes as well as vasomotor and mood symptoms. Growing research has contributed to our knowledge of the role of hypothalamic estrogen-sensitive kisspeptin/neurokinin B/dynorphin neurons. These neurons are thought to integrate the gonadotropin-releasing hormone pathway and the pathways responsible for the homeostatic control of body temperature and the circadian regulation of sleep-wake cycles. Understanding these neurons offers the potential to create treatments that target a key cause of sleep disturbance associated with the menopause. Further research to understand their etiology and characterize the neuronal circuits responsible could benefit the development of these targeted treatment approaches.

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Section: Discussion/observations Clinical Presentation Of Sleep Distu...mentioning

confidence: 99%

Sleep disturbance associated with the menopause

Maki,

Panay,

Simon

2024

Menopause

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“…In a meta-analysis, sleep disturbances during menopause were found to be common and significant. According to the results of the analysis, the general prevalence of sleep disorders based on these studies was 51.6% [ 121 ]. Deviation from the recommended 7–8 h of sleep in adults is associated with a higher risk of mortality and cardiovascular events [ 122 ].…”

Section: Sleep and Menopausementioning

confidence: 99%

The Importance of Nutrition in Menopause and Perimenopause—A Review

Erdélyi,

Pálfi,

Tűű

et al. 2023

Nutrients

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Menopause is associated with an increased prevalence of obesity, metabolic syndrome, cardiovascular diseases, and osteoporosis. These diseases and unfavorable laboratory values, which are characteristic of this period in women, can be significantly improved by eliminating and reducing dietary risk factors. Changing dietary habits during perimenopause is most effectively achieved through nutrition counseling and intervention. To reduce the risk factors of all these diseases, and in the case of an already existing disease, dietary therapy led by a dietitian should be an integral part of the treatment. The following review summarizes the recommendations for a balanced diet and fluid intake, the dietary prevention of cardiovascular diseases, the role of sleep, and the key preventive nutrients in menopause, such as vitamin D, calcium, vitamin C, B vitamins, and protein intake. In summary, during the period of perimenopause and menopause, many lifestyle factors can reduce the risk of developing all the diseases (cardiovascular disease, insulin resistance, type 2 diabetes mellitus, osteoporosis, and tumors) and symptoms characteristic of this period.

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“…Проведен метаанализ 41 исследования из 3 998 статей, посвященных проблеме сна во время менопаузы [33]. В результате проведенного анализа данных установлено, что общая распространенность нарушений сна во всех исследованиях составила 51,6%.…”

Section: нарушения сна во время менопаузыunclassified

Menopause and sleep disturbances

Stenyaeva,

Khritinin,

Stenyaev

2023

Medicinskij sovet

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The menopause in a woman’s life is one of the most significant events indicating the large-scale changes in the hypothalamus-pituitary-ovarian axis function. Gonadal steroid hormones are actively involved in the central nervous system (CNS) growth, differentiation, physiology and ageing processes. Sleep provides restoration of the central nervous system, and also contributes to memory consolidation. Sleep influences the two primary effector systems, the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS), which in turn regulate adaptive and innate immune responses. During sleep, blood levels of cortisol, adrenaline and norepinephrine drop, whereas the levels of neurotransmitters such as growth hormone, prolactin and melatonin show a steep increase. We get more and more facts showing the role of sleep in the processes of immunogenesis and metabolism, in particular fat metabolism. A systematic modern literature analysis on the prevalence and structure of sleep disturbances in women during pre-, peri- and postmenopause was carried out. The results of individual studies revealing the relationship between sleep disturbances and hormone levels including levels of sex steroids are presented. A review of current scientific evidence shows conclusively that the neuroendocrine system significantly determines the sleep quality. Sleep disturbances associated with RLS, COAC are highly prevalent, especially among postmenopausal women, due to declining ovarian function and deficiency of sex steroids. The results of conducted studies support the continued study and analysis of the relationships between gender, neuroendocrine factors, sleep disorders and the search for effective methods for their treatment. SonNorm Duo containing melatonin, peppermint leaf oil, and motherwort herb extract is one of the drugs used to manage sleep disturbances. SonNorm Duo is an adaptogenic sedative drug that is indicated for sleep disturbances, circadian rhythm sleep-wake disorders associated with rapid travel across multiple time zones.

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Global prevalence of sleep disorders during menopause: a meta-analysis

Cited by 18 publications

References 55 publications

Sleep disturbance associated with the menopause

Sleep disturbance associated with the menopause

The Importance of Nutrition in Menopause and Perimenopause—A Review

Menopause and sleep disturbances

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