Global public health problem of sudden cardiac death

Mehra, Rahul

doi:10.1016/j.jelectrocard.2007.06.023

Cited by 310 publications

(184 citation statements)

References 12 publications

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“…Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for 30% of all deaths 1) . Most of this disease burden is in low-and middle-income countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Adults in Beijing, China

Cai

Zhang

Liu

et al. 2012

JAT

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Aim:The present study aimed to determine the up-to-date prevalence, awareness, treatment, and control of dyslipidemia, and their distribution and related influencing factors in adults in Beijing, China. Method: A cross-sectional study was conducted in 2008, using a four-stratified cluster sampling. Data from a questionnaire, physical examination, and blood sampling were obtained from 5761 adults aged 18-79 years.

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“…Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for 30% of all deaths 1) . Most of this disease burden is in low-and middle-income countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Adults in Beijing, China

Cai

Zhang

Liu

et al. 2012

JAT

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“…Abnormal propagation of such waves may result in the onset of life-threatening conditions. For example, ventricular fibrillation, a result of abnormal turbulent excitation of the heart, is a leading cause of death worldwide, accounting for about 6 million deaths annually (2). Understanding and characterizing wave propagation, especially at the whole organ level, is an important problem in cardiac electrophysiology.…”

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confidence: 99%

Anisotropy of wave propagation in the heart can be modeled by a Riemannian electrophysiological metric

Young

Panfilov

2010

Proc. Natl. Acad. Sci. U.S.A.

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It is well established that wave propagation in the heart is anisotropic and that the ratio of velocities in the three principal directions may be as large as v f ∶v s ∶v n ≈ 4ðfibersÞ∶2ðsheetsÞ∶ 1ðnormalÞ. We develop an alternative view of the heart based on this fact by considering it as a non-Euclidean manifold with an electrophysiological(el-) metric based on wave velocity. This metric is more natural than the Euclidean metric for some applications, because el-distances directly encode wave propagation. We develop a model of wave propagation based on this metric; this model ignores higher-order effects like the curvature of wavefronts and the effect of the boundary, but still gives good predictions of local activation times and replicates many of the observed features of isochrones. We characterize this model for the important case of the rotational orthotropic anisotropy seen in cardiac tissue and perform numerical simulations for a slab of cardiac tissue with rotational orthotropic anisotropy and for a model of the ventricles based on diffusion tensor MRI scans of the canine heart. Even though the metric has many slow directions, we show that the rotation of the fibers leads to fast global activation. In the diffusion tensor MRI-based model, with principal velocities 0.25∶05∶1 m∕s, we find examples of wavefronts that eventually reach speeds up to 0.9 m∕s and average velocities of 0.7 m∕s. We believe that development of this non-Euclidean approach to cardiac anatomy and electrophysiology could become an important tool for the characterization of the normal and abnormal electrophysiological activity of the heart. cardiac arrhythmias | cardiac electrophysiology | diffusion tensor MRI | patient-specific cardiac models | Riemannian geometry

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“…Approximately 50% of all deaths in patients with ischemic heart disease are unexpected, occurring shortly after onset of symptoms. Concomitantly with the increasing number of patients with ischemic heart disease -especially in the Western world -annual worldwide mortality rates due to SCD have risen to an estimated 7 million patients [2][3][4].…”

Section: Editorialmentioning

confidence: 99%

Primary prevention implantable cardioverter–defibrillator treatment: how to identify patients most likely to benefit?

Thijssen

Rees

Schalij

et al. 2012

Expert Review of Cardiovascular Therapy

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Global public health problem of sudden cardiac death

Cited by 310 publications

References 12 publications

Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Adults in Beijing, China

Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Adults in Beijing, China

Anisotropy of wave propagation in the heart can be modeled by a Riemannian electrophysiological metric

Primary prevention implantable cardioverter–defibrillator treatment: how to identify patients most likely to benefit?

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