Global publication trends and research hotspots of curcumin application in tumor: A 20-year bibliometric approach

Abstract

Malignant tumor is a disease caused by the imbalance of cell growth and proliferation mechanism, which seriously threatens human health and life safety. However, side effects and drug resistance are the key factors that limit the efficacy of anti-tumor drugs. Therefore, it is urgent and necessary to explore and unearth natural, safe and effective chemosensitizers in tumor researches. Curcumin is the main active ingredient in Curcuma, which has anti-inflammatory, anti-inflammatory and anti-oxidation effects, and has inhibitory effects on a variety of cancers. Bibliometric analysis is a scientific and quantitative method to assess the published articles, which can help researchers to find the development trends and the research hotspots of a specific research field, providing the development of future research for researchers. This study searched the Web Science Core Collection (woscc) for publications related to curcumin and tumors from January 1, 2001 to December 31, 2021. The specific characteristics of 1707 publications were analyzed by using Microsoft Excel software, CiteSpace, Vosviewer and online analysis platform of literature metrology. China had the largest number of published articles, with 579 publications. Aggarwal BB’s articles total citations and average citations were the most. PLoS One had the largest number of publications, with 32 publications. The current research focuses on “nanoparticles”, “delivery”, “micells” and “doxorubicin”. At present, nano based drug delivery system to improve the bioavailability of curcumin and thus to treat tumors will be the focus of future research.

Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

“…These lipid carriers provide a tailored delivery system for curcumin, ensuring its targeted arrival at cancer cells. Known for its anti-inflammatory and anticancer properties, curcumin’s potential is maximized when encapsulated within liposomes, enhancing its bioavailability and therapeutic impact [ 64 ]. This strategic combination of liposomes and curcumin represents a noteworthy avenue in the ongoing pursuit of innovative and effective cancer therapies.…”

“…Curcumin has been demonstrated to increase the responsiveness of cancer cells to chemotherapy, making it a beneficial component in liposome formulations [ 71 ]. This novel approach has been utilized in the management of several forms of cancer, such as breast, ovarian, and lung malignancies, providing a promising solution for patients in search of more efficient and less harmful treatment alternatives [ 64 ]. These liposome formulations have potential applications beyond cancer therapy, demonstrating the adaptability of combining standard chemotherapeutic drugs with natural chemicals in sophisticated drug delivery systems for treating many disorders.…”

Recent updates on clinical developments of curcumin and its derivatives

“…Other reliable methods to enhance the bioavailability of curcumin in humans comprise the use of liposomes (Gota et al, 2010) structural analogs (Anand et al, 2007) and phospholipid complexes (Cuomo et al, 2011), and so forth. The nontoxicity and safety of high dose of curcumin has been confirmed by several human trials in the past few years (Baum et al, 2008; DiSilvestro et al, 2012; Ringman et al, 2012; Zhang et al, 2022). Moreover, curcumin has been approved by the US Food and Drug Administration (FDA) as “Generally Recognized as Safe” (Anand et al, 2007), and good safety and tolerability profiles of curcumin have been shown by clinical trials even at doses between 4000 and 8000 mg/day without imparting any toxic effects in patients (Ringman et al, 2012; Tak et al, 2022).…”

“…Other reliable methods to enhance the bioavailability of curcumin in humans comprise the use of liposomes (Gota et al, 2010) structural analogs (Anand et al, 2007) and phospholipid complexes (Cuomo et al, 2011), and so forth. The nontoxicity and safety of high dose of curcumin has been confirmed by several human trials in the past few years (Baum et al, 2008;DiSilvestro et al, 2012;Ringman et al, 2012;Zhang et al, 2022).…”

Nanomaterials for diabetic wound healing: Visualization and bibliometric analysis from 2011 to 2021

“…Bibliometrics is an interdisciplinary subject that can be applied to conduct quantitative and qualitative analyses of publications by using mathematical and statistical methods ( 19 ). It includes the contributions and influence of different authors, countries/regions, institutions, journals, and trends ( 20 ).…”