Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Steinmetz, Jaimie D; Culbreth, Garland T; Haile, Lydia M; Rafferty, Quinn; Lo, Justin; Fukutaki, Kai; Cruz, Jessica A; Smith, Amanda E.; Vollset, Stein Emil; Brooks, Peter; Cross, Marita; Woolf, Anthony D.; Hagins, Hailey; Abbasi‐Kangevari, Mohsen; Abedi, Aidin; Ackerman, Ilana N.; Amu, Hubert; Antony, Benny; Arabloo, Jalal; Aravkin, Aleksandr Y.; Mamo, Ayele; Artamonov, Anton A; Ashraf, Tahira; Barrow, Amadou; Bearne, Lindsay; Benseñor, Isabela M.; Berhie, Alemshet Yirga; Bhardwaj, Nikha; Bhardwaj, Pankaj; Bhojaraja, Vijayalakshmi S; Bijani, Ali; Briant, Paul Svitil; Briggs, Andrew M.; Butt, Nadeem Shafique; Charan, Jaykaran; Chattu, Vijay Kumar; Cicuttini, Flavia Maria; Coberly, Kaleb; Dadras, Omid; Dai, Xiaochen; Dandona, Lalit; Dandona, Rakhi; Luca, Katie de; Denova‐Gutiérrez, Edgar; Dharmaratne, Samath D; Dhimal, Meghnath; Dianatinasab, Mostafa; Dreinhoefer, Karsten E; Elhadi, Muhammed; Farooque, Umar; Farpour, Hamid Reza; Filip, Irina; Fischer, Florian; Freitas, Marisa; Ganesan, Balasankar; Gemeda, Belete Negese Belete; Getachew, Tamiru; Ghamari, Seyyed‐Hadi; Ghashghaee, Ahmad; Gill, Tiffany K.; Golechha, Mahaveer; Golinelli, Davide; Gupta, Bhawna; Gupta, Veer Bala; Gupta, Vivek Kumar; Haddadi, Rasool; Hafezi-Nejad, Nima; Halwani, Rabih; Hamidi, Samer; Hanif, Asif; Harlianto, Netanja I; Haro, Josep María; Hartvigsen, Jan; Hay, Simon I.; Hébert, Jeffrey J.; Heidari, Golnaz; Hosseini, Mohammad-Salar; Hosseinzadeh, Mehdi; Hsiao, Alexander Kevin; Ilić, Irena; Ilic, Milena D; Jacob, Louis; Jayawardena, Ranil; Jha, Ravi Prakash; Jonas, Jost B.; Joseph, Nitin; Kandel, Himal; Karaye, Ibraheem M.; Khan, Muhammad Naseem; Kim, Yun Jin; Kolahi, Ali‐Asghar; Korzh, Oleksii; Koteeswaran, Rajasekaran; Krishnamoorthy, Vijay; Kumar, G Anil; Kumar, Narinder; Lee, Sang-woong; Lim, Stephen S; Lobo, Stany W.; Lucchetti, Giancarlo; Malekpour, Mohammad‐Reza; Malik, Ahmad Azam; Mandarano-Filho, Luiz Garcia; Martini, Santi; Mentis, Alexios-Fotios A; Mesregah, Mohamed Kamal; Meštrović, Tomislav; Mirrakhimov, Aibek E.; Misganaw, Awoke; Mohammadpourhodki, Reza; Mokdad, Ali H.; Momtazmanesh, Sara; Morrison, Shane D; Murray, Christopher J L; Nassereldine, Hasan; Netsere, Henok Biresaw; Kandel, Sandhya Neupane; Owolabi, Mayowa; Panda‐Jonas, Songhomitra; Pandey, Anamika; Pawar, Shrikant; Pedersini, Paolo; Pereira, Jeevan; Radfar, Amir; Rashidi, Mohammad‐Mahdi; Rawaf, David Laith; Rawaf, Salman; Rawassizadeh, Reza; Rayegani, Seyed Mansoor; Ribeiro, Daniela; Roever, Leonardo; Saddik, Basema; Sahebkar, Amirhossein; Salehi, Sana; Sànchez-Riera, Lídia; Sanmarchi, Francesco; Santric-Milicevic, Milena M; Shahabi, Saeed; Shaikh, Masood Ali; Shaker, Elaheh; Shannawaz, Mohammed; Sharma, Rajendra K.; Sharma, Saurab; Shetty, Jeevan K.; Shiri, Rahman; Shobeiri, Parnian; Silva, Diego Augusto Santos; Singh, Ambrish; Singh, Jasvinder A; Singh, Surjit; Skou, Søren Thorgaard; Slater, Helen; Soltani-Zangbar, Mohammad Sadegh; Starodubova, A. V.; Tehrani-Banihashemi, Arash; Tahbaz, Sahel Valadan; Valdez, Pascual; Vo, Bay; Vu, Linh Gia; Wang, Yuan‐Pang; Jabbari, Seyed Hossein Yahyazadeh; Yonemoto, Naohiro; Yunusa, Ismaeel; March, Lyn; Ong, Kanyin; Vos, Theo; Kopeć, Jacek A.

doi:10.1016/s2665-9913(23)00163-7

Cited by 295 publications

(63 citation statements)

References 42 publications

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“…Osteoarthritis is a leading cause of global disability, and affected about 595 million people in 2020 6. This represents a prevalence change increase of 132.2% since 1990, partly owing to a growth in ageing populations and rising levels of obesity worldwide 16. Consequently, osteoarthritis flares are likely to be encountered more in clinical practice.…”

Section: What Are Osteoarthritis Flares?mentioning

confidence: 99%

Recognising and managing osteoarthritis flares in primary care

Parry,

Walker,

Thomas

2023

BMJ

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Section: What Are Osteoarthritis Flares?mentioning

confidence: 99%

Recognising and managing osteoarthritis flares in primary care

Parry,

Walker,

Thomas

2023

BMJ

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“…Osteoarthritis (OA) is prevalent in middle-aged and older adults, with 10% of the world's population aged 60 or older facing a serious clinical problem of OA, and the incidence of the disease is increasing annually. 1,2 A statistical analysis of OA-related data from 195 countries over the past 30 years showed that the number of OA patients had increased by 9.3% compared to 1990, affecting an estimated 303 million people worldwide. 3 In addition, with the prevalence of obesity in the population and the increased chance of accidental joint injuries due to exercise, the age of onset of this joint disease has gradually tended to be younger, which warrants a high degree of vigilance.…”

Section: Introductionmentioning

confidence: 99%

Cyaonoside A-loaded composite hydrogel microspheres to treat osteoarthritis by relieving chondrocyte inflammation

An,

Zhou,

et al. 2024

J. Mater. Chem. B

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“…End-stage knee osteoarthritis is commonly treated with total knee arthroplasty (TKA) . In 2018, more than 715 000 TKAs were performed in the US, and the number is expected to rise to 1.9 million annually by 2030 .…”

Section: Introductionmentioning

confidence: 99%

Exercise and Pain Neuroscience Education for Patients With Chronic Pain After Total Knee Arthroplasty

Larsen,

Skou,

Laursen

et al. 2024

JAMA Netw Open

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ImportanceUp to 20% of patients develop chronic pain after total knee arthroplasty (TKA), yet there is a scarcity of effective interventions for this population.ObjectiveTo evaluate whether neuromuscular exercise and pain neuroscience education were superior to pain neuroscience education alone for patients with chronic pain after TKA.Design, Setting, and ParticipantsA superiority randomized clinical trial was conducted at 3 outpatient clinics at Aalborg University Hospital in Denmark. Participants with moderate-to-severe average daily pain intensity and no signs of prosthesis failure at least 1 year after primary TKA were included. Participant recruitment was initiated on April 12, 2019, and completed on October 31, 2022. The 12-month follow-up was completed on March 21, 2023.InterventionsThe study included 24 sessions of supervised neuromuscular exercise (2 sessions per week for 12 weeks) and 2 total sessions of pain neuroscience education (6 weeks between each session) or the same pain neuroscience education sessions alone. The interventions were delivered in groups of 2 to 4 participants.Main Outcomes and MeasuresThe primary outcome was change from baseline to 12 months using the mean score of the Knee Injury and Osteoarthritis Outcome Score, covering the 4 subscales pain, symptoms, activity of daily living, and knee-related quality of life (KOOS4; scores range from 0 to 100, with higher scores indicating better outcomes). The outcome assessors and statistician were blinded. All randomized participants were included in the intention-to-treat analysis.ResultsAmong the 69 participants (median age, 67.2 years [IQR, 61.2-71.9 years]; 40 female [58%]) included in the study, 36 were randomly assigned to the neuromuscular exercise and pain neuroscience education group, and 33 to the pain neuroscience education–alone group. The intention-to-treat analysis showed no between-group difference in change from baseline to 12 months for the KOOS4 (7.46 [95% CI, 3.04-11.89] vs 8.65 [95% CI, 4.67-12.63] points; mean difference, −1.33 [95% CI, −7.59 to 4.92]; P = .68). Among the 46 participants who participated in the 12-month assessment in the 2 groups, 16 (34.8%) experienced a clinically important improvement (a difference of ≥10 points on the KOOS4) with no between-group difference. No serious adverse events were observed.Conclusions and RelevanceIn this randomized clinical trial, the results demonstrated that neuromuscular exercises and pain neuroscience education were not superior to pain neuroscience education alone in participants with chronic pain after TKA. Approximately one-third of the participants, regardless of intervention, experienced clinically important improvements. Future studies should investigate which patient characteristics indicate a favorable response to exercises and/or pain neuroscience education.Trial RegistrationClinicalTrials.gov Identifier: NCT03886259

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Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

Cited by 295 publications

References 42 publications

Recognising and managing osteoarthritis flares in primary care

Recognising and managing osteoarthritis flares in primary care

Cyaonoside A-loaded composite hydrogel microspheres to treat osteoarthritis by relieving chondrocyte inflammation

Exercise and Pain Neuroscience Education for Patients With Chronic Pain After Total Knee Arthroplasty

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