2022
DOI: 10.3389/fphys.2022.925132
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Global, regional, and national burden of chronic obstructive pulmonary disease from 1990 to 2019

Abstract: Background: We aimed to estimate the incidence, mortality, disability-adjusted life years (DALYs) for chronic obstructive pulmonary disease (COPD) in 204 countries and territories. We examined the variations in these trends by country, gender, age group, and sociodemographic index (SDI).Methods: We calculated the estimated annual percentage changes (EAPCs) to assess temporal trends in the age-standardized incidence rate, age-standardized mortality rate, and age-standardized DALYs of COPD from 1990 to 2019.Resu… Show more

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Cited by 10 publications
(8 citation statements)
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“…The excess mortality rate level of 2.4 in Poland in 2021 was high; yet, it was comparable to the level for Central European countries (2.5). Higher values of excess mortality rates were recorded in 2019 only in Eastern European and high-income Asia Pacific countries and were 3.4 and 2.85, respectively [25]. The decline in mortality rates due to COPD is a worldwide phenomenon as well.…”
Section: Comparison With Other Studiesmentioning
confidence: 95%
“…The excess mortality rate level of 2.4 in Poland in 2021 was high; yet, it was comparable to the level for Central European countries (2.5). Higher values of excess mortality rates were recorded in 2019 only in Eastern European and high-income Asia Pacific countries and were 3.4 and 2.85, respectively [25]. The decline in mortality rates due to COPD is a worldwide phenomenon as well.…”
Section: Comparison With Other Studiesmentioning
confidence: 95%
“…The prevalence of this disease varies depending on the nation, encompassing several phenotypes that are currently under discussion. 3 COPD is also associated with consequential comorbidities. The main challenge in the upcoming years will be to mitigate the negative effects of smoking beyond early detection of sickness in the general population.…”
Section: Epidemiologymentioning
confidence: 99%
“… 13 The main clinical manifestations are chronic cough, sputum, shortness of breath or dyspnea, 14 wheezing, chest tightness, and other symptoms. COPD is diagnosed when the ratio of forceful expiratory volume in the first second to all expiratory volume (FEV1/FVC) is <70% 15 after inhalation of bronchodilators, indicating persistent airflow limitation, combined with the patient’s clinical presentation and the presence of high-risk factors such as smoking, dust or chemical irritation, infection, and the exclusion of other diseases. The common pathogenesis of COPD includes 16 , 17 chronic inflammatory mechanisms involving neutrophils, macrophages and lymphocytes; protease and anti-protease imbalance caused by an increase in protein hydrolases and a decrease in anti-protease; oxidative stress mechanisms and other mechanisms that increase oxidation beyond the body’s antioxidant capacity, leading to an oxidative and antioxidant imbalance.…”
Section: Chronic Obstructive Pulmonary Diseasementioning
confidence: 99%
“…Cigarette smoke and environmental pollution 1 , 15 can bring a large number of exogenous chemicals, oxides, etc. activated inflammatory cells in the lungs can release endogenous oxides, 53 when these substances exceed the body’s antioxidant capacity, the imbalance between oxidation and antioxidant causes oxidative stress, resulting in airway epithelial damage, reduced ciliary movement and release of NE, which in turn causes cellular dysfunction or apoptosis, inflammatory response, accumulation of mucus substances and their easy elimination, extracellular matrix destruction, protease/anti-protease imbalance, etc., leading to the development and progression of COPD and increased comorbidity.…”
Section: The Role Of Glp-1ras In Copdmentioning
confidence: 99%