Global, regional and national burden of Glaucoma: an update analysis from the Global Burden of Disease Study 2019

Chen, Wenli; Xu, Yi; Liu, Ziya; Zhao, Jing

doi:10.1007/s10792-024-03222-6

Int Ophthalmol

2024

DOI: 10.1007/s10792-024-03222-6

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Global, regional and national burden of Glaucoma: an update analysis from the Global Burden of Disease Study 2019

Wenli Chen,

Yi Xu,

Ziya Liu

et al.

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Cited by 3 publications

References 25 publications

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One-Year Comparison of Efficacy and Safety of PreserFlo MicroShunt with Mitomycin C Applied by Sub-Tenon Injection Versus Sponge

Majtanova,

Takacova,

Kurilova

et al. 2024

Ophthalmol Ther

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One-Year Comparison of Efficacy and Safety of PreserFlo MicroShunt with Mitomycin C Applied by Sub-Tenon Injection Versus Sponge

Majtanova,

Takacova,

Kurilova

et al. 2024

Ophthalmol Ther

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Elevated serum uric acid levels mediate the associations of ambient PM2.5 and its components with glaucoma

Li,

Meng

et al. 2024

Chemosphere

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The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma

Kapic,

Zaman,

Nguyen

et al. 2024

Cells

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We report a three-pronged phenotypic evaluation of the bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) that selectively produces 17β-estradiol (E2) in the retina after topical administration and halts glaucomatous neurodegeneration in a male rat model of the disease. Ocular hypertension (OHT) was induced by hyperosmotic saline injection into an episcleral vein of the eye. Animals received daily DHED eye drops for 12 weeks. Deterioration of visual acuity and contrast sensitivity by OHT in these animals were markedly prevented by the DHED-derived E2 with concomitant preservation of retinal ganglion cells and their axons. In addition, we utilized targeted retina proteomics and a previously established panel of proteins as preclinical biomarkers in the context of OHT-induced neurodegeneration as a characteristic process of the disease. The prodrug treatment provided retina-targeted remediation against the glaucomatous dysregulations of these surrogate endpoints without increasing circulating E2 levels. Collectively, the demonstrated significant neuroprotective effect by the DHED-derived E2 in the selected animal model of glaucoma supports the translational potential of our presented ocular neuroprotective approach owing to its inherent therapeutic safety and efficacy.

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Global, regional and national burden of Glaucoma: an update analysis from the Global Burden of Disease Study 2019

Cited by 3 publications

References 25 publications

One-Year Comparison of Efficacy and Safety of PreserFlo MicroShunt with Mitomycin C Applied by Sub-Tenon Injection Versus Sponge

One-Year Comparison of Efficacy and Safety of PreserFlo MicroShunt with Mitomycin C Applied by Sub-Tenon Injection Versus Sponge

Elevated serum uric acid levels mediate the associations of ambient PM2.5 and its components with glaucoma

The Prodrug DHED Delivers 17β-Estradiol into the Retina for Protection of Retinal Ganglion Cells and Preservation of Visual Function in an Animal Model of Glaucoma

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