Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study

Song, Peige; Adeloye, Davies; Salim, Hani; Santos, Jhonathan Pr Dos; Campbell, Harry; Sheikh, Aziz; Rudan, Igor

doi:10.7189/jogh.12.04052

Cited by 110 publications

(54 citation statements)

References 23 publications

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“…Asthma during pregnancy remains a significant public health issue. Globally, asthma affects 8–13% of pregnant women, with recent estimates suggesting that this number continues rise [2–4]. The prevalence of asthma during pregnancy is likely higher than this current estimate, given the challenges of diagnosing, treating and reporting asthma in many areas of the world [5].…”

Section: Epidemiologymentioning

confidence: 85%

Asthma in pregnancy: a review of recent literature

Colas,

Namazy

2024

Current Opinion in Pulmonary Medicine

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Purpose of review Asthma remains the most common respiratory disease in pregnancy. Identifying risk factors for asthma exacerbations during pregnancy is critical, as uncontrolled asthma can have detrimental effects for both mother and baby. In this review, we discuss recent literature exploring risk factors, fetal and maternal effects, and treatment options for asthma during pregnancy. Recent findings Recent literature suggests that optimizing asthma during pregnancy improves outcomes for both mother and baby, as well as later in childhood. Current research affirms that the benefit of asthma medication use outweighs any potential risks related to the medications themselves. Limited information is available regarding the use of newer therapies such as biologics during pregnancy. Summary Identifying risk factors for asthma exacerbations during pregnancy is critical to prevent adverse outcomes for both mother and baby. Recent evidence continues to affirm the safety of asthma medication use; more studies are needed regarding the use of new therapies during pregnancy.

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Section: Epidemiologymentioning

confidence: 85%

Asthma in pregnancy: a review of recent literature

Colas,

Namazy

2024

Current Opinion in Pulmonary Medicine

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“…In the analyses of symptom control and exacerbation occurrence, patients provided 2-9 reports (median 4, IQR [2-5]), with a mean (SD) follow-up of 492 (419) days (range 116-1759 days). For the EQ-5D and PROMIS-PAIS analyses, reports per patient ranged from 1-8, with medians of 2 (IQR [1][2][3]) and 3 (IQR [2-4]), respectively. The characteristics of participants are presented in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Impact of Treatment Adherence and Inhalation Technique on asthma outcomes of Pediatric Patients: A Longitudinal Study

Lizano-Barrantes,

Garin,

Mayoral

et al. 2023

Preprint

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IntroductionWe aimed to evaluate the longitudinal relationships, both at between- and within-person levels, that adherence to inhaled corticosteroids-based maintenance treatment and inhalation technique present with symptom control, exacerbations, and health-related quality of life (HRQoL) in children and adolescents with asthma.MethodsParticipants (6-14 years old) from the ARCA (Asthma Research in Children and Adolescents) cohort - a prospective, multicenter, observational study (NCT04480242) - were followed for a period from 6 months to 5 years, via computer-assisted telephone interviews and a smartphone application. The Medication Intake Survey–Asthma (MIS-A) was administered to assess the implementation stage of adherence; and the Inhalation Technique Questionnaire (InTeQ) to assess the five key steps when using an inhaler. Symptoms control was measured with the Asthma Control Questionnaire (ACQ), and HRQL with the EQ-5D and the PROMIS-Pediatric Asthma Impact Scale (PROMIS-PAIS). Multilevel longitudinal mixed models were constructed separately with symptom control, exacerbation occurrence, EQ-5D, and PROMIS-PAIS as dependent variables.ResultsOf 360 participants enrolled, 303 (1203 interviews) were included in the symptom control and exacerbation analyses, 265 (732) in the EQ-5D, and 215 (619) in the PROMIS-PAIS. Around 60% of participants were male and most underwent maintenance treatment with inhaled corticosteroids plus long-acting β-agonists in a fixed dose (68–74%). Within-person variability was 83.6% for asthma control, 98.6% for exacerbations, 36.4% for EQ-5D and 49.1% for PROMIS-PAIS. At within-person level, patients with higher adherence had better symptom control (p=0.002) and HRQoL over time (p=0.016). Patients with better inhalation technique reported worse HRQoL simultaneously (p=0.012), but better HRQoL in future assessments (p=0.012). Frequency of reliever use was associated with symptom control (p<0.001), exacerbation occurrence (p<0.001), and HRQoL (p=0.042); and boys were more likely to present better symptom control and HRQoL than girls.ConclusionOur results confirm longitudinal associations at within-person level of the two indicators of quality use of inhalers: for adherence to maintenance treatment with symptom control and HRQoL, and for inhalation technique with HRQoL. Although treatment adherence showed to be excellent, a third part of participants reported a suboptimal inhalation technique, highlighting the need of actions for improving asthma management of pediatric population.

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“…Pediatric asthma represents a major public health issue, currently affecting more that 12% of children worldwide, with higher prevalence rates reported in high‐income countries compared with low‐ and middle‐income countries 1 . As a chronic inflammatory disease of the airways, asthma often manifests through symptoms such as wheezing, coughing, shortness of breath, and tightness in the chest, which can substantially impact health.…”

Section: Introductionmentioning

confidence: 99%

The impact of perinatal and at birth risk factors on the progression from preschool wheezing to adolescent asthma

Gallagher,

Batra,

Malamardi

et al. 2024

Pediatric Allergy Immunology

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Asthma is a global health concern affecting millions of children and adolescents. This review focuses on the possible factors that are associated with the transition from preschool wheezing to childhood asthma and highlights the significance of early‐life environmental exposures during pregnancy and the first 6 months of life in shaping allergies and asthma. We observed a scarcity of studies investigating this subgroup, with most focusing on wheezing trajectories. We undertook a thorough investigation of diverse perinatal exposures that have the potential to impact this transition. These factors include maternal asthma, smoking during pregnancy, diet, prepregnancy weight, infant birthweight, gestational age, and breastfeeding. Although limited, studies do suggest that maternal asthma increases the likelihood of preschool wheeze in offspring that persists through childhood with potential asthma progression. Findings concerning other perinatal exposures remain inconsistent. Further research is needed to identify asthma progression risk factors and assess perinatal exposure effects.

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Global, regional, and national prevalence of asthma in 2019: a systematic analysis and modelling study

Cited by 110 publications

References 23 publications

Asthma in pregnancy: a review of recent literature

Asthma in pregnancy: a review of recent literature

Impact of Treatment Adherence and Inhalation Technique on asthma outcomes of Pediatric Patients: A Longitudinal Study

The impact of perinatal and at birth risk factors on the progression from preschool wheezing to adolescent asthma

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