Global research trends and foci of artificial intelligence-based tumor pathology: a scientometric study

Shen, Zefeng; Hu, Jintao; Wu, Haiyang; Chen, Zeshi; Wu, Weixia; Lin, Jinran; Xu, Zhi-Fang; Kong, Jianqiu; Lin, Tianxin

doi:10.1186/s12967-022-03615-0

Cited by 44 publications

(41 citation statements)

References 66 publications

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“…Bibliometrics is a branch of library and information science that integrates mathematical and statistical methods to quantitatively analyze the published scientific literature, and then discusses its structure, characteristics and change trends in a certain period ( Cheng et al, 2022a ; Li et al, 2022a ; Shen et al, 2022a ; Cheng et al, 2022b ). In recent years, with more and more free open-source software such as CitNetExplorer, CiteSpace, HistCite, VOSviewer, and Bibliometrix have been developed, bibliometrics relying on literature databases has been frequently applied in biomedical field ( Synnestvedt et al, 2005 ; van Eck and Waltman, 2010 ; Aria and Cuccurullo, 2017 ; Liu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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Background: Ultrasound-triggered sonodynamic therapy (SDT), as a non-invasive approach, has attracted considerable attention in a wide variety of malignant tumors and other diseases. Over the past 2 decades, the number of scientific publications on SDT has increased rapidly. However, there is still a lack of one comprehensive report that summarizes the global research trends and knowledge landscapes in the field of SDT in detail. Thus, we performed a bibliometric analysis on SDT from 2000 to 2021 to track the current hotspots and highlight future directions.Methods: We collected publications on SDT research from the Web of Science Core Collection database. The annual number of publications and citations, major contributors, popular journals, international collaborations, co-cited references and co-occurrence keywords were analyzed and visualized with CiteSpace, VOSviewer, and R-bibliometrix.Results: A total of 701 publications were included. The annual publication output increased from 5 in 2000 to 175 in 2021, and the average growth rate was 18.4%. China was the most productive country with 463 documents (66.05%), and Harbin Medical University was the most prolific institution (N = 73). Ultrasound in Medicine and Biology published the most papers related to SDT. Materials Science, and Chemistry were the research areas receiving the most interest. All the keywords were divided into four different clusters including studies on mechanisms, studies on drug delivery and nanoparticles, studies on cancer therapy, as well as studies on ultrasound and sonosensitizers. In addition to nanomaterials-related studies including nanoparticles, mesoporous silica nanoparticles, nanosheets, liposomes, microbubble and TiO2 nanoparticle, the following research directions such as immunogenic cell death, metal-organic framework, photothermal therapy, hypoxia, tumor microenvironment, chemodynamic therapy, combination therapy, tumor resistance, intensity focused ultrasound, drug delivery, and Staphylococcus aureus also deserve further attention and may continue to explode in the future.Conclusion: SDT has a bright future in the field of cancer treatment, and nanomaterials have increasingly influenced the SDT field with the development of nano-technology. Overall, this comprehensive bibliometric study was the first attempt to analyze the field of SDT, which could provide valuable references for later researchers to better understand the global research trends, hotspots and frontiers in this domain.

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Section: Introductionmentioning

confidence: 99%

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Cheng

Shen

et al. 2023

Front. Pharmacol.

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“…Although there were various treatment strategies such as surgery, radiotherapy, chemotherapy and neoadjuvant chemotherapy, the 5 years survival rate of OS patients had only a small improvement over the past 35 years. Thus, the development of individualized diagnostic and therapeutic strategies is imminent ( 19 , 20 ). In most life forms, metals are important parts of most enzymatic functions and are closely related to most basic biological processes.…”

Section: Discussionmentioning

confidence: 99%

A cuproptosis-related genes signature associated with prognosis and immune cell infiltration in osteosarcoma

Yang

Wu²,

Tong³

et al. 2022

Front. Oncol.

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Osteosarcoma (OS) is one of the most prevalent primary bone tumors at all ages of human development. The objective of our study was to develop a model of Cuproptosis-Related Genes (CRGs) for predicting prognosis in OS patients. All datasets of OS patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and Gene Expression Omnibus (GEO) database. We obtained the gene set (81 CRGs) related to cuproptosis by accessing the database and previous literature. All the CRGs were analyzed by univariate COX regression, least absolute shrinkage and selection operator (LASSO) COX regression analysis to screen for CRGs associated with prognosis in OS patients. Then these CRGs were used to construct a prognostic signature, which was further verified by independent cohort (GSE21257) and clinical correlation analysis. Afterward, to identify underlying mechanisms, Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were used for the high-risk group by using the GSEA method. The association between the prognostic signature and 28 types of immune infiltrating cells in the tumor microenvironment was assessed. Ultimately, Lipoic Acid Synthetase (LIAS) (HR=0.632, P=0.004), Lipoyltransferase 1 (LIPT1) (HR=0.524, P=0.011), BCL2 Like 1 (BCL2L1/BCL-XL) (HR=0.593, P=0.022), and Pyruvate Dehydrogenase Kinase 1 (PDK1) (HR=0.662, P=0.025) were identified. Subsequently, they were used to calculate the risk score and build a prognostic model. In the training cohort, risk score (HR=1.878, P=0.003) could be considered as an independent prognostic factor, and OS patients with high-risk scores showed lower survival rates. Biological pathways related to substance metabolism and transport were enriched. There were significant differences in immune infiltrating cells in the tumor microenvironment. All in all, The CRGs signature is related to the tumor immune microenvironment and could be used as a credible predictor of the prognostic status in OS patients.

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“…Literature on PCa and immunotherapy from 1999 to 2021 was searched using the Science Citation Index-Expanded (SCIE) of the Web of Science Core Collection (WoSCC). WoSCC is one of the most professional and authoritative citation-based databases with powerful indexing functions, which not only contains the basic information including authors, institutions, countries/regions, funding agencies, and author keywords but also includes the reference information ( 24 – 26 ). The search was conducted until 24 April 2022.…”

Section: Methodsmentioning

confidence: 99%

“…of the most professional and authoritative citation-based databases with powerful indexing functions, which not only contains the basic information including authors, institutions, countries/regions, funding agencies, and author keywords but also includes the reference information (24)(25)(26). The search was conducted until 24 April 2022.…”

Section: Data Retrieval Strategymentioning

confidence: 99%

Knowledge mapping and current trends of immunotherapy for prostate cancer: A bibliometric study

Zhong

Shen

et al. 2022

Front. Immunol.

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BackgroundProstate cancer (PCa) is the second most common malignancy in men worldwide. Growing evidence substantiates the important role of immunotherapy in human tumors. Given that immunotherapy is often unsatisfactory on PCa, many studies have been conducted on PCa immunotherapy to improve treatment efficacy. However, no relevant bibliometric study of PCa immunotherapy has hitherto been reported. A bibliometric analysis was performed to evaluate the global scientific production of PCa immunotherapy research and characterize the development trends for future studies in this article.MethodsThe publications related to PCa immunotherapy were extracted from the Web of Science Core Collection. The contribution and co-occurrence relationships of countries/regions, institutions, journals, references, authors, and keywords were assessed and visualized by VOSviewer and CiteSpace to identify research hotspots and potential future trends.ResultsA total of 3,583 publications related to PCa immunotherapy from 1999 to 2021 were collected. The results of annual publications and citations exhibited a steady increase over the past 22 years. The National Cancer Institute in the USA published far more papers during the study than any institute. Accordingly, the USA had the most publications (n = 1,954, 54.54%). Gulley, James L. had the most number of published papers, and Small, Eric J. was the most co-cited authors in this field. Cancer Immunology Immunotherapy was the most productive journal, with 145 publications on PCa immunotherapy. Keyword cluster and keyword burst analyses showed that research in PCa immunotherapy shifted from “t cell infiltration” and “sipuleucel t” to “immune checkpoint inhibitor”, “CTLA-4”, and “PD-L1 expression”.ConclusionPCa immunotherapy has attracted much attention, reflected by the increasing number of annual publications and citations. Much emphasis has been placed on exploring the complex immunogenicity and tumor microenvironment for PCa and identifying the patient population who can benefit from immunotherapy. Combining immune checkpoint inhibitors with other therapeutic options and cancer vaccines represents the future development trends in PCa immunotherapy.

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Global research trends and foci of artificial intelligence-based tumor pathology: a scientometric study

Cited by 44 publications

References 66 publications

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

Mapping knowledge landscapes and emerging trends of sonodynamic therapy: A bibliometric and visualized study

A cuproptosis-related genes signature associated with prognosis and immune cell infiltration in osteosarcoma

Knowledge mapping and current trends of immunotherapy for prostate cancer: A bibliometric study

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