Global Research Trends of Herbal Medicine for Pain in Three Decades (1990–2019): A Bibliometric Analysis

Wang, Chennan; Meng, Qingcai

doi:10.2147/jpr.s311311

Cited by 23 publications

(28 citation statements)

References 52 publications

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“…Korea (140 articles, 30.13%) and China (81 articles, 17.5%) are the countries that published the most papers in this field, and many universities and research institutes in these countries are also ranked high when analyzed by research organizations. It appears that East Asia is the leading continent of worldwide research on herbal medicine for obesity, and their results are similar to the results of other bibliometric analysis papers on herbal medicines [22,23] . In particular, research organizations in Korea published almost a quarter of the total number of articles in this study, and this may be due to the fact that various collaborative studies have been conducted at university research institutes where the Department of Oriental Medicine and Food Engineering were jointly established.…”

Section: Discussionsupporting

confidence: 82%

“…It appears that East Asia is the leading continent of worldwide research on herbal medicine for obesity, and their results are similar to the results of other bibliometric analysis papers on herbal medicines. [ 22 , 23 ] In particular, research organizations in Korea published almost a quarter of the total number of articles in this study, and this may be due to the fact that various collaborative studies have been conducted at university research institutes where the Department of Oriental Medicine and Food Engineering were jointly established. The subjects of research from these institutions were diverse, and the main subjects were clinical trial studies conducted to determine the efficacy and side effects of herbal medicines.…”

Section: Discussionmentioning

confidence: 99%

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A bibliometric analysis of research on herbal medicine for obesity over the past 20 years

et al. 2022

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Background: The aim of this study was to analyze published papers on the use of herbal medicine in obesity research over the past 20 years using bibliometric methods and present an overview of global research trends. Methods: English articles on herbal medicine for obesity published from 2001 to 2020 were retrieved from the Web of Science Core Collection database using the search terms “herbal” AND “obesity”. Microsoft Office Excel was used to sort and analyze the statistical data. Bibliographic analysis and data visualization were performed using visualization of similarities viewer based on publication year, country of publication, journal, research area, author, affiliated institution, and keywords. Results: A total of 463 English articles were retrieved, and we observed a trend in which the number of publications on herbal medicine for obesity has gradually increased over the past 20 years. The most productive countries and research organizations in this field were Korea and Kyunghee University, respectively. Many papers have been published in research areas, such as pharmacology pharmacy and integrative complementary medicine, and the journals with the most published articles in this field were Journal of Ethnopharmacology and Evidence-Based Complementary and Alternative Medicine. The main research keywords formed 3 clusters, and keywords with the most occurrences were “obesity,” “adipose-tissue,” and “insulin resistance.” Conclusion: This study presents an overview of the global research trend of herbal medicine for obesity from the bibliographic analysis. An increased understanding of the recently changing research topics provides a new perspective on future research directions. This study may help guide the research in the field of obesity in the future.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of research on herbal medicine for obesity over the past 20 years

et al. 2022

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“…et al, 2014;Lin PH. et al, 2016;Arai et al, 2020;Wang and Meng, 2021). Recently, a number of clinical and experimental studies on various problems caused by cancer have been reported based on the scientific methodological approach for East Asian herbal medicine (EAHM) (Lin et al, 2019;Tsai et al, 2019;Kim et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

East Asian Herbal Medicine to Reduce Primary Pain and Adverse Events in Cancer Patients : A Systematic Review and Meta-Analysis With Association Rule Mining to Identify Core Herb Combination

Seo²,

Choi

et al. 2022

Front. Pharmacol.

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Objective: Cancer pain is an important factor in cancer management that affects a patient’s quality of life and survival-related outcomes. The aim of this review was to systematically evaluate the efficacy and safety of oral administration of East Asian herbal medicine (EAHM) for primary cancer pain and to explore core herb patterns based on the collected data.Methods: A comprehensive literature search was conducted in 11 electronic databases, namely, PubMed, Cochrane Library, Cumulative Index to Nursing & Allied Health Literature, EMBASE, Korean Studies Information Service System, Research Information Service System, Oriental Medicine Advanced Searching Integrated System, Korea Citation Index, Chinese National Knowledge Infrastructure Database (CNKI), Wanfang Data, and CiNii for randomized controlled trials from their inception until August 19, 2021. Statistical analysis was performed in R version 4.1.1 and R studio program using the default settings of the meta-package. When heterogeneity in studies was detected, the cause was identified through meta-regression and subgroup analysis. Methodological quality was independently assessed using the revised tool for risk of bias in randomized trials (Rob 2.0).Results: A total of 38 trials with 3,434 cancer pain patients met the selection criteria. Meta-analysis favored EAHM-combined conventional medicine on response rate (risk ratio: 1.06; 95% CI: 1.04 to 1.09, p < 0.0001), continuous pain intensity (standardized mean difference: −1.74; 95% CI: −2.17 to −1.30, p < 0.0001), duration of pain relief (standardized mean difference: 0.96, 95% CI: 0.69 to 1.22, p < 0.0001), performance status (weighted mean difference: 10.71; 95% CI: 4.89 to 16.53, p = 0.0003), and opioid usage (weighted mean difference: −20.66 mg/day; 95% CI: −30.22 to −11.10, p < 0.0001). No significant difference was observed between EAHM and conventional medicine on response rate and other outcomes. Patients treated with EAHM had significantly reduced adverse event (AE) incidence rates. In addition, based on the ingredients of herb data in this meta-analysis, four combinations of herb pairs, which were frequently used together for cancer pain, were derived.Conclusion: EAHM monotherapy can decrease adverse events associated with pain management in cancer patients. Additionally, EAHM-combined conventional medicine therapy may be beneficial for patients with cancer pain in increasing the response rate, relieving pain intensity, improving pain-related performance status, and regulating opioid usage. However, the efficacy and safety of EAHM monotherapy are difficult to conclude due to the lack of methodological quality and quantity of studies. More well-designed, multicenter, double-blind, and placebo-controlled randomized clinical trials are needed in the future. In terms of the core herb combination patterns derived from the present review, four combinations of herb pairs might be promising for cancer pain because they have been often distinctly used for cancer patients in East Asia. Thus, they are considered to be worth a follow-up study to elucidate their actions and effects.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42021265804

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“…Scientometrics can well reveal the disciplinary development process, research status, and development trend and has been widely used in the research of various disciplines. Wang [ 4 ] explored the research trends of Chinese herbal medicine in relieving pain by applying scientometrics. Zhong [ 5 ] applied scientometrics to study the pathogenesis of epilepsy.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric Analysis of Network Pharmacology in Traditional Chinese Medicine

Miao

Meng

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aim. We evaluated the developmental process, research status, and existing challenges of network pharmacology. Moreover, we elucidated the corresponding solutions to improve and develop network pharmacology. Methods. Research data for the current study were retrieved from the Web of Science. The developmental process of network pharmacology was analyzed using HisCite, whereas cooccurrence analysis of countries, institutions, keywords, and references in literature was conducted using CiteSpace. Results. In literature, there was a trend of annual increase of studies on network pharmacology and China was found to be the country with the most published literature on network pharmacology. The main publishing research institutions were universities of traditional Chinese medicine (TCM). The keywords with more research frequency were TCM, mechanisms, molecular docking, and quercetin, among others. Conclusion. Currently, studies on network pharmacology are mainly associated with the exploration of action mechanisms of TCM. The main active ingredient in many Chinese medicines is quercetin. This ingredient may lead to deviation of research results, inability to truly analyze active ingredients, and even mislead the research direction of TCM. Such deviation may be because the database fails to reflect the content and composition changes of Chinese medicinal components. The database does not account for interactions among components, targets, and diseases, and it ignores the different pathological states of the disease. Therefore, network pharmacology should be improved from the databases and research methods.

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Global Research Trends of Herbal Medicine for Pain in Three Decades (1990–2019): A Bibliometric Analysis

Cited by 23 publications

References 52 publications

A bibliometric analysis of research on herbal medicine for obesity over the past 20 years

A bibliometric analysis of research on herbal medicine for obesity over the past 20 years

East Asian Herbal Medicine to Reduce Primary Pain and Adverse Events in Cancer Patients : A Systematic Review and Meta-Analysis With Association Rule Mining to Identify Core Herb Combination

Bibliometric Analysis of Network Pharmacology in Traditional Chinese Medicine

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