Global Seasonality of Human Coronaviruses: A Systematic Review

Park, Sangshin; Lee, Yeonjin; Michelow, Ian C.; Choe, Young June

doi:10.1093/ofid/ofaa443

Cited by 53 publications

(58 citation statements)

References 41 publications

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“…Seasonality can induce variations in vital signs including body temperature, blood pressure 28 , and in turn these can affect and influence the different disease populations (e.g., diabetes, cardiovascular, obesity, and others) 29 – 31 . A seasonal variation of deaths from corona viruses was also observed recently 32 . Thus, the months/seasons may have important interactions with the vital signs beyond the known seasonal susceptibility to influenza.…”

Section: Discussionsupporting

confidence: 53%

A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients

et al. 2021

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Patients with influenza and SARS-CoV2/Coronavirus disease 2019 (COVID-19) infections have a different clinical course and outcomes. We developed and validated a supervised machine learning pipeline to distinguish the two viral infections using the available vital signs and demographic dataset from the first hospital/emergency room encounters of 3883 patients who had confirmed diagnoses of influenza A/B, COVID-19 or negative laboratory test results. The models were able to achieve an area under the receiver operating characteristic curve (ROC AUC) of at least 97% using our multiclass classifier. The predictive models were externally validated on 15,697 encounters in 3125 patients available on TrinetX database that contains patient-level data from different healthcare organizations. The influenza vs COVID-19-positive model had an AUC of 98.8%, and 92.8% on the internal and external test sets, respectively. Our study illustrates the potentials of machine-learning models for accurately distinguishing the two viral infections. The code is made available at https://github.com/ynaveena/COVID-19-vs-Influenza and may have utility as a frontline diagnostic tool to aid healthcare workers in triaging patients once the two viral infections start cocirculating in the communities.

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Section: Discussionsupporting

confidence: 53%

A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients

et al. 2021

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“…Recent studies have demonstrated the cross-reactivity of the endemic hCoVs induced pre-existing humoral and cellular immune responses with SARS-CoV-2 [ [30] , [31] , [32] ], but at what extent these responses influence the course of the infection or the severity of the disease, is not fully understood. We found significantly better SARS-CoV-2 cross-reactivity in the sera of children, with high endemic hCoV burden [ 7 ]. Interestingly, Tso et al [ 30 ] found a correlation between pre-pandemic sera SARS-CoV-2 cross-recognition and low incidence of SARS-CoV-2 infection in sub-Saharan Africa, where the incidence of endemic hCoVs is high.…”

Section: Discussionmentioning

confidence: 99%

“…There are four circulating endemic hCoVs, 229E, NL43, OC43 and HKU1, the two former are classified to alpha-, and the two latter to beta-CoVs [ 2 ]. These low-pathogenic hCoVs are causative agents in approximately 5% of respiratory tract infections globally [ 7 ], affecting especially children under 10 years of age [ [7] , [8] , [9] , [10] ]. Although endemic hCoVs are randomly detected in the nasal swabs and stools of hospitalized children, they are considered to play a marginal role in severe pediatric respiratory infections [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults

Tamminen

Salminen

Blazevic

2021

Clinical Immunology

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Endemic human coronaviruses (hCoVs) are common causative agents of respiratory tract infections, affecting especially children. However, in the ongoing SARS-CoV-2 pandemic, children are the least affected age-group. The objective of this study was to investigate the magnitude of endemic hCoVs antibodies in Finnish children and adults, and pre-pandemic antibody cross-reactivity with SARS-CoV-2. Antibody levels against endemic hCoVs start to rise at a very early age, reaching to overall 100% seroprevalence. No difference in the antibody levels was detected for OC43 but the magnitude of 229E-specific antibodies was significantly higher in the sera of children. OC43 and 229E hCoV antibody levels of children correlated significantly with each other and with the level of cross-reactive SARS-CoV-2 antibodies, whereas these correlations completely lacked in adults. Although none of the sera showed SARS-CoV-2 neutralization, the higher overall hCoV cross-reactivity observed in children might, at least partially, contribute in controlling SARS-CoV-2 infection in this population.

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“…However, a recent systematic review by Park et al ( 22 ) revealed a consistent winter peak of sCoV incidence in the northern hemisphere (akin to other respiratory viruses), with moderate decrease during the summer months. It has to be noted that there is a substantial variation in the percentage of sCoVs infections in different epidemiological studies that appraised patients with acute respiratory infections.…”

Section: An Overview and Global Trendsmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g., enveloped viruses such as seasonal coronaviruses) in the local context can aid substantially in targeted and cost-effective utilization of viral diagnostic approaches. For the other, non-enveloped and year-round viruses (i.e., rhinovirus, adenovirus, and bocavirus), a continuous virological diagnosis needs to be implemented in clinical laboratories to more effectively address the aetiology of respiratory infections, and assess the overall impact of these viruses on disease burden. While the coronavirus disease 2019 (COVID-19) pandemic is still actively unfolding, we aimed to emphasize the persistent role of seasonal coronaviruses, rhinoviruses, adenoviruses and bocaviruses in the aetiology of respiratory infections. Consequently, this paper concentrates on the burden and epidemiological trends of aforementioned viral groups on a global level, but also provides a snapshot of their prevalence patterns in Croatia in order to underscore the potential implications of viral seasonality. An overall global prevalence in respiratory tract infections was found to be between 0.5 and 18.4% for seasonal coronaviruses, between 13 and 59% for rhinoviruses, between 1 and 36% for human adenoviruses, and between 1 and 56.8% for human bocaviruses. A Croatian dataset on patients with respiratory tract infection and younger than 18 years of age has revealed a fairly high prevalence of rhinoviruses (33.4%), with much lower prevalence of adenoviruses (15.6%), seasonal coronaviruses (7.1%), and bocaviruses (5.3%). These insights represent a relevant discussion point in the context of the COVID-19 pandemic where the testing of non-SARS-CoV-2 viruses has been limited in many settings, making the monitoring of disease burden associated with other respiratory viruses rather difficult.

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Global Seasonality of Human Coronaviruses: A Systematic Review

Cited by 53 publications

References 41 publications

A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients

A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients

Seroprevalence and SARS-CoV-2 cross-reactivity of endemic coronavirus OC43 and 229E antibodies in Finnish children and adults

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

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