“…Specific modular metabolic networks also participate in the transcriptional system, such as miRNA regulatory networks (Gennarino et al, 2012 ), transcription factor networks (Neph et al, 2012 ), RNA polymerase complexes (Schubert, 2014 ), and mRNA dynamics (Vlasova-St Louis and Bohjanen, 2011 ). Metabolic subsystems, i.e., self-organized multienzymatic associations, can be considered to be elemental catalytic modules in the cell (De la Fuente et al, 2008 , 2010 , 2014 ).…”