2010
DOI: 10.1371/journal.pone.0009484
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Global Self-Regulation of the Cellular Metabolic Structure

Abstract: BackgroundDifferent studies have shown that cellular enzymatic activities are able to self-organize spontaneously, forming a metabolic core of reactive processes that remain active under different growth conditions while the rest of the molecular catalytic reactions exhibit structural plasticity. This global cellular metabolic structure appears to be an intrinsic characteristic common to all cellular organisms. Recent work performed with dissipative metabolic networks has shown that the fundamental element for… Show more

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Cited by 19 publications
(16 citation statements)
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“…In this sense, the relationship between chaotic patterns and long-term correlations (information correlated in time [165]) is a striking property.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In this sense, the relationship between chaotic patterns and long-term correlations (information correlated in time [165]) is a striking property.…”
Section: Discussionmentioning
confidence: 99%
“…This global and stable cellular metabolic structure (in which also emerge chaotic behaviors) appears to be an intrinsic characteristic common to all cellular organisms [163165]. …”
Section: Discussionmentioning
confidence: 99%
“…Specific modular metabolic networks also participate in the transcriptional system, such as miRNA regulatory networks (Gennarino et al, 2012 ), transcription factor networks (Neph et al, 2012 ), RNA polymerase complexes (Schubert, 2014 ), and mRNA dynamics (Vlasova-St Louis and Bohjanen, 2011 ). Metabolic subsystems, i.e., self-organized multienzymatic associations, can be considered to be elemental catalytic modules in the cell (De la Fuente et al, 2008 , 2010 , 2014 ).…”
Section: Functional Organization Of Enzymes In Metabolic Networkmentioning
confidence: 99%
“…For example, the interactions between co-regulated metabolic enzymes can reveal the assembly of higher-order noncovalent protein complexes, called metabolons, which channel products to substrates along sequential steps of a metabolic pathway 1,2 . Protein-protein interactions can also reveal relationships between substrates and post-translational modifying enzymes, such as kinases, phosphatases, acetyltransferases and proteases, or with coactivator/co-repressor assemblies that modulate the specificity and activation of core complex functions 311 .…”
Section: Introductionmentioning
confidence: 99%