A growing awareness of global climate change has led to an increased interest in investigating renewable energy sources, such as the anaerobic digestion of biomass. This process utilizes a wide range of microbial communities to degrade biodegradable material in feedstock through a complex series of biochemical interactions. Anaerobic digestion exhibits nonlinear dynamics due to the complex and interacting biochemical processes involved. Due to its dynamic and nonlinear behavior, uncertain feedstock quality, and sensitivity to the process’s environmental conditions, anaerobic digestion is highly susceptible to instabilities. Therefore, in order to model and operate a biogas production unit effectively, it is necessary to understand which parameters are most influential on the model outputs. This also reduces the amount of estimation required. Through a scoping review, the present study analyzes the studies on the application of sensitivity analysis in anaerobic digestion modeling. Both local and global sensitivity analysis approaches were carried out using different mathematical models. The results indicate that anaerobic digestion model no.1 (ADM1) was the most commonly used model for analyzing sensitivity. Both local and global sensitivity analyses are widely employed to investigate the influence of key model parameters such as kinetic, stoichiometric, and mass transfer parameters on model outputs such as biogas production, methane concentration, pH, or economic viability of the plant.