Global standardization measurement of cerebral spinal fluid for Alzheimer's disease: An update from the Alzheimer's Association Global Biomarkers Consortium

Abstract

Recognizing that international collaboration is critical for the acceleration of biomarker standardization efforts and the efficient development of improved diagnosis and therapy, the Alzheimer's Association created the Global Biomarkers Standardization Consortium (GBSC) in 2010. The consortium brings together representatives of academic centers, industry, and the regulatory community with the common goal of developing internationally accepted common reference standards and reference methods for the assessment of cerebrospinal fluid (CSF) amyloid β42 (Aβ42) and tau biomarkers. Such standards are essential to ensure that analytical measurements are reproducible and consistent across multiple laboratories and across multiple kit manufacturers. Analytical harmonization for CSF Aβ42 and tau will help reduce confusion in the AD community regarding the absolute values associated with the clinical interpretation of CSF biomarker results and enable worldwide comparison of CSF biomarker results across AD clinical studies.

Assessing the commutability of reference material formats for the harmonization of amyloid-β measurements

“…The aim of the IFCC WG-CSF is to develop reference measurement procedures (RMPs) and CRMs for the AD CSF bio markers [30,31]. One important step in this standardization Values represent correlation coefficient.…”

Quantification of Tau in Cerebrospinal Fluid by Immunoaffinity Enrichment and Tandem Mass Spectrometry

“…Therefore, our IA-MS assay provides a useful tool that can be used in the better understanding and qualification of immunoassays. This is of particular value for current collaborative efforts, such as with the Global Consortium for the Standardization of CSF Biomarkers (21 ), which is working to establish standardized reference methods for the measurement of clinical AD biomarkers.…”

CSF in Alzheimer's Disease

“…These initiatives include the Alzheimer's Association Global Consortium for Biomarker Standardization (GCBS) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Working Group for CSF Proteins [212]. Standard operating procedures for CSF sampling and storage have been published [82] and a selected reaction monitoring mass spectrometry-based method for Ab1-42 has been described [213].…”