SUMMARYThe problem of global adaptive state regulation is investigated via output feedback for uncertain feedforward nonlinear time-delay systems. Compared with existing results, our control schemes can be applicable to more general nonlinear time-delay systems because of combining the low-gain scaling approach with the backstepping method. In particular, we allow that there exist uncertain output function and uncertain growth rate imposed on nonlinear terms. Also, one considers a class of nonlinear systems with main-axis delay. By the Lyapunov-Krasovskii theorem, delay-independent controllers are proposed by constructing novel lowgain observers driven by system input, to regulate the states of original system while all the closed-loop signals are globally bounded. Furthermore, two examples are given to illustrate the usefulness of our results.