Global status of antimicrobial resistance among environmental isolates of Vibrio cholerae O1/O139: a systematic review and meta-analysis

Abstract

Background Vibrio cholerae O1/O139 were the predominant circulating serogroups exhibiting multi-drug resistance (MDR) during the cholera outbreak which led to cholera treatment failures. Objective This meta-analysis aimed to evaluate the weighted pooled resistance (WPR) rates in V. cholerae O1/O139 isolates obtained from environmental samples. Methods We systematically searched the articles in PubMed, Scopus, and Embase (until January 2020). Subgroup analyses were then employed by publication year, geographic areas, and the quality of studies. Statistical analyses were conducted using STATA software (ver. 14.0). Results A total of 20 studies investigating 648 environmental V. cholerae O1/O139 isolates were analysed. The majority of the studies were originated from Asia (n = 9). In addition, a large number of studies (n = 15 i.e. 71.4%) included in the meta-analysis revealed the resistance to cotrimoxazole and ciprofloxacin. The WPR rates were as follows: cotrimoxazole 59%, erythromycin 28%, tetracycline 14%, doxycycline 5%, and ciprofloxacin 0%. There was increased resistance to nalidixic acid, cotrimoxazole, furazolidone, and tetracycline while a decreased resistance to amoxicillin, ciprofloxacin, erythromycin, chloramphenicol, ampicillin, streptomycin, and ceftriaxone was observed during the years 2000–2020. A significant decrease in the doxycycline and ciprofloxacin-resistance rates in V. cholerae O1/O139 isolates was reported over the years 2011–2020 which represents a decrease in 2001–2010 (p < 0.05). Conclusions Fluoroquinolones, gentamicin, ceftriaxone, doxycycline, kanamycin, and cefotaxime showed the highest effectiveness and the lowest resistance rate. However, the main interest is the rise of antimicrobial resistance in V. cholerae strains especially in low-income countries or endemic areas, and therefore, continuous surveillance, careful appropriate AST, and limitation on improper antibiotic usage are crucial.

Vibrio cholerae O1 associated with recent endemic cholera shows temporal changes in serotype, genotype, and drug-resistance patterns in Bangladesh

“…As a result, the organism tends to have a uctuating antibiotic susceptibility pattern. However, owing to the overuse of antibiotics, recent environmental and clinical V. cholerae strains appear to be multi-drug resistant acquiring different resistance genes (34). Such acquisition of resistance and related genes can be both temporary and persisting, as demonstrated by the results presented in this study.…”

A systematic review and meta-analysis on antimicrobial resistance in marine bivalves

“…In most cases, the geographical origin of samples was not reported. The methods used to assess AMR varied, particularly for marine bacteria, reflecting a lack of standardisation of susceptibility testing for these microorganisms, as already described by other authors ( Baron et al, 2017 ; Lin et al, 2022 ; Yuan et al, 2022 ). In addition, the studies tested a range of different antibiotics, sometimes belonging to the same class, reporting only aggregate data.…”

Isolation and characterization of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacterial pathogens from diverse environmental niches of Shimla, Himachal Pradesh (India)

“…In this study, environmental isolates were most resistant to Nitrofurantoin (80%) followed by Furazolidonones (70%), Oxytetracycline (66.66%) and 56.67% each for Nalidixic acid, Clarithromycin & Co-trimoxazole. A systematic review and meta-analysis on global status of antimicrobial resistance among environmental isolates of Vibrio cholera O1/O139 also reported increased resistance to nalidixic acid, co-trimoxazole, furazolidone and tetracycline during the years 2000-2020 [33]. Similarly, high resistance was also seen against ampicillin (92.30%), cefazolin (88.46%), ceftazidime (73.0%), and uoroquinolones (65.38%), in UTI isolates from tertiary care hospital in New Delhi [34].…”