The aim of the study is to examine the effect of tourism management as a panacea for sustainability of hospitality industry in Nigeria. The study applied a quantitative method involving a survey design. A questionnaire measurement instrument was constructed and deployed on a sample of 455 respondents in the hotels, packs, tourism destinations and attraction sites included in the study. Exploratory Factor Analysis (EFA) was used to validate the constructs in the measurement instrument. Structural Equation Model (SEM) was used to estimate structural relationship between tourism management dimensions and sustainability of hospitality industry. The analysis was aided by AMOS software version 23. The results showed that destinations management, management of attraction sites, management of tourist transportation system, management of tourism intermediaries and management of security system has significant positive effect on the sustainability of hospitality industry. Therefore, the study concluded that effective tourism management and adoption of workable strategies is vital for the development and growth of the tourism sector and significant towards enhancing the tourism ecosystem and sustainability of hospitality industry.