Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

Abstract

Background Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting inflammasomes is a promising approach for the treatment of stroke. Methods We applied bibliometric methods and techniques. The Web of Science Core Collection was searched for studies indexed from database inception to November 26, 2020. We generated various visual maps to display publications, authors, sources, countries, and keywords. Results Our literature search yielded 427 publications related to inflammasomes involved in stroke, most of which consisted of original research articles and reviews. In particular, we found that there was a substantial increase in the number of relevant publications in 2018. Furthermore, most of the publications with the highest citation rates were published in 2014. Relatively, the field about inflammasomes in stroke developed rapidly in 2014 and 2018. Many institutions contributed to these publications, including those from China, the United States, and worldwide. We found that NLR family pyrin domain containing 3 (NLRP3) was the most studied, followed by NLRP1, NLRP2, and NLRC4 among the inflammasomes associated with stroke. Analysis of keywords suggested that the most studied mechanisms involved dysregulation of extracellular pH, efflux of Ca2+ ions, dysfunction of K+/Na+ ATPases, mitochondrial dysfunction, and damage to mitochondrial DNA. Conclusions Given the potential diagnostic and therapeutic implications, the specific mechanisms of inflammasomes contributing to stroke warrant further investigation. We used bibliometric methods to objectively present the global trend of inflammasomes in stroke, and to provide important information for relevant researchers.

A Bibliometric Analysis for Global Trends and Full View of the Autophagy in Ischemic Stroke from 2006 to 2022

“…As a tool widely used for qualitative and quantitative analysis of global scientific literature, bibliometric analysis can effectively show the knowledge structure and possible development trend of specific fields through information visualization [16][17][18]. Bibliometric analysis has been performed in the research field of nervous system diseases [19,20].…”

A bibliometric analysis of NLRP3 inflammasome in acute lung injury/acute respiratory distress syndrome from 2010 to 2021

“…In this study, we focused on depicting the characteristics and searching for emerging trends of the literature data about NLRP3 inflammasome in ALI/ARDS from 2010 to 2021 from the SCIE database, using CiteSpace (5.8.R3) for visualization. Although related themes of bibliometric studies were conducted, including inflammasome in neurological diseases (49)(50)(51), there is no bibliometric analysis focusing on NLRP3 inflammasome in ALI/ARDS so far. Chen Wang's work (2020) (52) retrieved a broad range of literature on ALI/ARDS during 2009-2019 from WOS, exploring the distribution of literature contribution and analyzing the trends of this specific disease in a wide dimension.…”

Bibliometric Analysis of Post-Stroke Pain Research Published from 2012 to 2021

“…17 It is extensively used to visualize the citation, cooperation, co-occurrence and other relationships within the literatures, and construct various types of knowledge maps, [17][18][19] and explore the critical paths, research hotspots, and frontiers of the evolution of this discipline or field. 20 In the past 10 years, bibliometric analyses have been conducted on other stroke-related research hotspots, such as inflammasomes, 21 traditional medicine, 22 and rehabilitation treatment. 23 They used bibliometric methods to objectively present the global trend of pathogenesis, treatments of stroke and to provide important information for relevant researchers.…”