Global Trends in Prevalence, Treatments, and Costs of Penile Prosthesis for Erectile Dysfunction in Men

Kohn, Taylor P.; Rajanahally, Saneal; Hsieh, Tung‐Chin; Raheem, Omer

doi:10.1016/j.euf.2021.05.003

Cited by 22 publications

(10 citation statements)

References 37 publications

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“…Penile prosthesis implantation (PPI) is currently the third-line treatment for ED. Because it can cause irreparable damage to the smooth muscle of the corpora cavernosa, it is usually considered when oral PDE5I drugs, intracavernosal injection, and VED therapy are ineffective (46). 3-piece inflatable prosthesis is the most common implant at present, and is also the most satisfactory (47).…”

Section: Penile Prosthesis Implantationmentioning

confidence: 99%

Management of male erectile dysfunction: From the past to the future

Wang

Peng

et al. 2023

Front. Endocrinol.

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Erectile dysfunction is a common disease of the male reproductive system, which seriously affects the life quality of patients and their partners. At present, erectile dysfunction is considered as a social-psychological-physiological disease with complex etiology and various treatment methods. Oral PDE5I is the first-line treatment for erectile dysfunction with the advantages of high safety, good effect and non-invasiveness. But intracavernosal injection, hormonal replacement therapy, vacuum erection device, penile prosthesis implantation can also be alternative treatments for patients have organic erectile dysfunction or tolerance to PDE5I. With the rapid development of technologies, some new methods, such as low-intensity extracorporeal shock wave and stem cell injection therapy can even repair the organic damage of the corpora cavernosa. These are important directions for the treatment of male erectile dysfunction in the future. In this mini-review, we will introduce these therapies in detail.

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Section: Penile Prosthesis Implantationmentioning

confidence: 99%

Management of male erectile dysfunction: From the past to the future

Wang

Peng

et al. 2023

Front. Endocrinol.

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“…However, against the above advantages, penile prosthesis implantation is highly expensive, traumatic (cavernous tissue is irreversibly damaged by the implantation procedure), and may also present severe, although rare, complications, such as prosthesis infection, pump migration and automatic inflation, which can require a second surgery and other interventions. These complication may be reduced by appropriate patient selection, strict adherence to antimicrobial prophylaxis and safe surgical practice, and preoperative informative counseling is essential for the patients in order to reach postimplantation satisfaction with their partners [274,275,[278][279][280][281].…”

Section: Penile Prosthesismentioning

confidence: 99%

Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies

Argiolas

et al. 2023

Brain Sciences

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Erectile dysfunction (ED) is the inability to get and maintain an adequate penile erection for satisfactory sexual intercourse. Due to its negative impacts on men’s life quality and increase during aging (40% of men between 40 and 70 years), ED has always attracted researchers of different disciplines, from urology, andrology and neuropharmacology to regenerative medicine, and vascular and prosthesis implant surgery. Locally and/or centrally acting drugs are used to treat ED, e.g., phosphodiesterase 5 inhibitors (first in the list) given orally, and phentolamine, prostaglandin E1 and papaverine injected intracavernously. Preclinical data also show that dopamine D4 receptor agonists, oxytocin and α-MSH analogues may have a role in ED treatment. However, since pro-erectile drugs are given on demand and are not always efficacious, new strategies are being tested for long lasting cures of ED. These include regenerative therapies, e.g., stem cells, plasma-enriched platelets and extracorporeal shock wave treatments to cure damaged erectile tissues. Although fascinating, these therapies are laborious, expensive and not easily reproducible. This leaves old vacuum erection devices and penile prostheses as the only way to get an artificial erection and sexual intercourse with intractable ED, with penile prosthesis used only by accurately selected patients.

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“…Erectile dysfunction (ED) is a common problem and is associated with numerous comorbidities and lifestyle factors ( 1 ). Implantation of a penile prostheses is a reliable treatment for men with ED refractory to less invasive therapies ( 2 - 4 ), as well as for female to male transgender patients ( 2 ). Improvements over the past decades in penile prosthesis technology and surgical techniques have improved the safety, reliability, and patient satisfaction rates for implants ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Narrative review of immediate salvage for penile prosthesis infection

Adams,

Tua-Caraccia,

Lentz

2024

Transl Androl Urol

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Background and Objective Implantation of a penile prosthesis is a reliable option for men with erectile dysfunction (ED) refractory to less invasive therapies. While the frequency of penile prosthesis infections have decreased, they remain a devastating complication. Herein we discuss why immediate salvage surgery is an essential technique for the management of implant infections. We will also describe the relevant advancements to this technique. Methods We conducted a narrative review via computer based search of PubMed for all relevant articles on penile prosthesis infection management, including guidelines, case series, reviews, and expert opinions. Search terms used included: “inflatable penile prosthesis”, “IPP”, “penile prosthesis”, “salvage”, “treatment”, “delayed”, “immediate”. Only English peer-reviewed publications were included. Key Content and Findings Historically, patients who presented with penile prosthesis infections were exclusively managed with complete removal of the prosthesis without replacement. Although this strategy is safe, it hastens immediate ED and corporal fibrosis, resulting in loss of penile length and increased difficulty with subsequent prosthesis replacement. Previous case series have reported successful treatment of localized penile prosthesis infections with nonsurgical treatment, but the role of conservative treatment remains limited. The current standard of immediate salvage entails removal of the infected prosthesis and washout followed by immediate replacement with a new penile prosthesis. This technique has been demonstrated to be safe and effective, thus allowing patients to resume intercourse and maintain penile length. Conclusions Immediate salvage surgery is safe and effective, and has emerged as the preferred strategy for the management of most patients with a penile prosthesis infection.

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Global Trends in Prevalence, Treatments, and Costs of Penile Prosthesis for Erectile Dysfunction in Men

Cited by 22 publications

References 37 publications

Management of male erectile dysfunction: From the past to the future

Management of male erectile dysfunction: From the past to the future

Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies

Narrative review of immediate salvage for penile prosthesis infection

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