Global trends in research on oxidative stress associated with periodontitis from 1987 to 2022: A bibliometric analysis

Abstract

BackgroundOxidative stress has been implicated in many chronic inflammatory diseases, including periodontitis. To date, however, only a few bibliometric analyses have systematically studied this field. This work sought to visualize research hot spots and trends in oxidative stress associated with periodontitis from 1987 to 2022 through bibliometric approaches.MethodsThe Web of Science Core Collection was searched to retrieve relevant publications. HistCite, VOSviewer, and CiteSpace were used to perform bibliometric analysis visually in terms of annual output, active countries, prolific institutions, authors, core journals, co-cited references, and co-occurrence of keywords.ResultsA total of 1654 documents were selected for analysis. From 1 January 1987 to 11 June 2022, the number of annual publications related to oxidative stress in periodontitis exhibited an upward trend. The most prolific country was China with 322 documents, but the United States had 11334 citations. Okayama University, University of Birmingham, and Sichuan University were the most active and contributive institutions. The Journal of Periodontology ranked first in terms of numbers of publications and citations. Ekuni was the most prolific author, while Chapple ranked first among co-cited authors. The Role of Reactive Oxygen and Antioxidant Species in Periodontal Tissue Destruction published by Chapple was the most frequently co-cited reference. Keywords co-occurrence showed that oxidative stress was closely related to inflammation, antioxidants, and diabetes.ConclusionOur research found that global publications regarding research on oxidative stress associated with periodontitis increased dramatically and were expected to continue increasing. Inflammation and oxidative stress, and the relationship between periodontitis and systemic diseases, are topics worthy of attention.

Molecular Basis of the Curative Effects of Turkish Gall Extracts on Periodontitis

“…In addition, lipopolysaccharides have been suggested as a molecular link between periodontal microbiota and cardiometabolic diseases [31] . Oxidative stress is conducive to periodontal tissue destruction, and periodontitis may promote the progression of kidney diseases, diabetes, and cardiovascular diseases through oxidative stress [32] . In contrast, antioxidant drugs can reduce ROS levels and alveolar bone loss caused by periodontitis [33] .…”

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“…It collected data on various entities (e.g., countries, institutions, journals) to nd out the hidden associations and facilitate understanding the research eld at a broader level [13]. This method had been used in several medical research to predict hotspots, review results and guide clinical therapy [14,15,16]. In the eld of ischemic stroke, it provides valuable reference for further study.…”