Global trends of Pseudomonas aeruginosa biofilm research in the past two decades: A bibliometric study

Abstract

Pseudomonas aeruginosa biofilm formation is a primary cause of chronic infections. This has been a highly active area of research over the past two decades due to causing high mortality risks in immunocompromised patients. This study evaluates global trends in the dynamic and rapidly evolving field of P. aeruginosa biofilm research through bibliometric and visualized analyses. Publications from 1994 to 2018 on P. aeruginosa biofilm research were retrieved from Web of Science, Scopus, and PubMed, and their bibliometric data were systematically studied. The VOSviewer software was used to conduct global analyses of bibliographic coupling, coauthorship, cocitation, and co‐occurrence. A total of 9,527 publications were included in this study. The overall number of publications and research interest in the field displayed a strongly rising trend. The USA made the greatest contributions to the field, with the highest h‐index and number of citations compared with other countries, while Denmark had the highest average citation per publication. The Journal of Bacteriology had the highest number of publications in the field, while the University of Copenhagen was the institution with the highest contribution influence. Co‐occurrence network maps revealed that the most prominent topics in P. aeruginosa biofilm research were mechanistic studies, in vitro/in vivo studies, and biofilm formation studies. Pseudomonas aeruginosa biofilms constitute a dynamic research area in microbiology with increasing global research interest. Future studies will likely focus on investigating the mechanisms of biofilm formation to solve infection‐associated clinical problems.

The Future of Mesenchymal Stromal Cells in cancer – A Bibliometric Analysis

“…The United States and the Peoples' Republic of China account for a signi cant volume. Both of these countries have been identi ed previously as power houses for publishing research in the eld of cancer and others (34)(35)(36)(37)(38). Despite their high overall output, correction for population has highlighted research hotspots such as Luxembourg, Switzerland and Singapore who lead the world in publications per capita but also have the highest average citations among all countries.…”

Global research trends of drug-induced liver injury (DILI) in the past two decades: a bibliometric and visualized study

“…Bibliometric is a statistical tool that is used to quantitative evaluate the influence of research literatures within a certain time frame, research countries, institutions, journals and research collaboration for any specific topic selected for study (14). Recently, bibliometric analysis extensively used in a series of research fields (15)(16)(17). Comparing the change of research hotspots by time, it provides a simple way to predict the future direction of this research field.…”

“…If two publications cite the same references, they are "coupled", indicating that the two publications may share the same references and produce the knowledge domain map of countries/ regions, institutions, and journals. The strength of the link between them shows the number of references cited in the two articles, which could be extended to analyze the link strength of journals, institutions, and countries publishing papers on specific topics to reflect the degree of bibliometric coupling (15). The strength of a link between two publications indicates the number of cited references these two publications have in common.…”

Pseudomonas aeruginosa Biofilm Dispersion by the Human Atrial Natriuretic Peptide

“…[ 13 ] These represent the most critical bacteria in terms of both antibiotic resistance and the ability to form recalcitrant biofilms urgently needing new therapeutic drugs. [ 14 , 15 , 16 , 17 ]…”

“…[13] These represent the most critical bacteria in terms of both antibiotic resistance and the ability to form recalcitrant biofilms urgently needing new therapeutic drugs. [14][15][16][17] In this global context, numerous nonantibiotic antivirulence agents such as quorum-sensing inhibitors, enzymes, or peptides have been proposed as alternative antimicrobial weapons [18][19][20] and/or as biofilm dispersal agents. [21][22][23][24][25][26] At least two main avenues are being explored to tackle biofilms.…”