2018
DOI: 10.1016/j.antiviral.2018.07.001
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Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016–2017

Abstract: A total of 13672 viruses, collected by World Health Organization recognised National Influenza Centres between May 2016 and May 2017, were assessed for neuraminidase inhibitor susceptibility by four WHO Collaborating Centres for Reference and Research on Influenza and one WHO Collaborating Centre for the Surveillance Epidemiology and Control of Influenza. The 50% inhibitory concentration (IC50) was determined for oseltamivir and zanamivir for all viruses, and for peramivir and laninamivir in a subset (n = 8457… Show more

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Cited by 114 publications
(112 citation statements)
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“…NAIs remain a widely licensed class of antiviral drugs appropriate for the treatment and prophylaxis of seasonal influenza 23 . However, there is still concern regarding the adverse effects of NAIs.…”
Section: Discussionmentioning
confidence: 99%
“…NAIs remain a widely licensed class of antiviral drugs appropriate for the treatment and prophylaxis of seasonal influenza 23 . However, there is still concern regarding the adverse effects of NAIs.…”
Section: Discussionmentioning
confidence: 99%
“…Neuraminidase Assay Kit (Applied Biosystems), according to the manufacturer's instructions. The susceptibility of influenza viruses to NAI was characterized using oseltamivir, zanamivir, and peramivir at concentrations that inhibited the NA activity by 50% (IC 50 ) as described previously [14].…”
Section: Na Inhibition Assaymentioning
confidence: 99%
“…NAIs can prevent virus release by inhibiting the influenza NA, resulting in aggregation of viruses at the cell surface . However, because of the rapid emergence of drug resistant virus , new anti‐influenza agents should be designed and synthesized with chemical characteristics clearly different from those of existing agents .…”
Section: Introductionmentioning
confidence: 99%