Global Use of Asbestos and the Incidence of Mesothelioma

Tossavainen, Antti

doi:10.1179/oeh.2004.10.1.22

Cited by 110 publications

(71 citation statements)

References 9 publications

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“…Analysis of asbestos consumption and mesothelioma incidence in various industrialized countries disclosed a significant correlation between the two variables 46,47) . A double-curve pattern may be observed in some countries: the curve of mesothelioma incidence mirrors the curve of the asbestos consumption, that has occurred some decades previously.…”

Section: Mesothelioma and Asbestosmentioning

confidence: 99%

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

2007

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Mesothelioma incidence varies markedly from one country to another. The highest annual crude incidence rates (about 30 cases per million) are observed in Australia, Belgium, and Great Britain. A lot of data indicate a relationship between mesothelioma and asbestos. The hot areas for mesothelioma exactly correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry. However, in many countries with high asbestos consumption, mesothelioma incidence is low. The reasons for this fact are not clear. The latency periods elapsing between first exposure to asbestos and development of mesothelioma are mostly longer than 40 yr. An inverse relationship exists between intensity of asbestos exposure and length of the latency period. Mesothelioma generally develops after long-time exposures to asbestos. Some recent studies show that the risk increases with the duration of exposure. Possible co-factors in the pathogenesis of asbestos-related mesothelioma include genetic predisposition, diets poor in fruit and vegetables, viruses, immune impairment, recurrent serosal inflammation. The study of co-morbidity in mesothelioma could give an insight into the pathogenesis of the tumor. While a levelling-off in mesothelioma incidence has been registered in some countries, a worsening of the epidemic is predictable in large parts of the world.

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Section: Mesothelioma and Asbestosmentioning

confidence: 99%

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

2007

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“…In France, malignant pleural mesothelioma accounts for about 80% of the pleural cancers among men (42 over 43 deaths occurred among male workers in our study) and asbestos exposure is its main etiological factor (Montanaro et al, 2003). At the time when nuclear industry expanded in France, in the early 1950's, asbestos was widely used in many industries, with a peak in the 1970's, before its use was prohibited in 1990 (Montanaro et al, 2003;Tossavainen, 2004;Goldberg et al, 2006). Asbestos exposure in the early years of nuclear industry may partly explain the elevated SMR for pleural cancer.…”

Section: Cancer Mortalitymentioning

confidence: 99%

Mortality in the French cohort of nuclear workers

et al. 2017

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-Populations of nuclear workers are particularly relevant to study health effects of protracted exposures to low doses at low dose-rates of ionizing radiation. In France, a cohort of nuclear workers employed by the Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AREVA Nuclear Cycle (AREVA NC), or Électricité de France (EDF), and badge-monitored for external radiation exposure, has been followed-up for several decades. Annual exposure to penetrating photons was reconstructed for each worker. Standardized mortality ratios were calculated using national mortality rates as the reference. Estimates of radiation dose-mortality associations were obtained using linear excess relative risk models. Mortality of 59 004 workers was followed-up between 1968 and 2004, for an average of 25 years. The mean cumulative photon H p (10) dose was 18.4 mSv in the whole cohort (median value: 2.1 mSv) and 25.7 mSv among exposed workers. At the end of the follow-up, workers were 56 years old on average and 6310 workers had died. A strong healthy worker effect was observed. Estimated dose-risk relationships were consistent with those from other worker studies for all solid cancers and leukaemia excluding chronic lymphocytic leukaemia, but remained associated to a large uncertainty. This cohort is the most informative study ever conducted in France among nuclear workers.

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“…The MOE analyzed the relation between mesothelioma deaths and asbestos imports in 11 countries based on the Tossavainen 6) report.…”

Section: Introductionmentioning

confidence: 99%

Future Trends of Mesothelioma Mortality in Japan Based on a Risk Function

et al. 2012

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Mesothelioma is a malignancy with poor prognosis. It is chiefly caused by asbestos exposure and its symptoms can occur about 30-50 yr after the initial exposure. This study aims to predict the future trends in mesothelioma mortality in Japan using a method that is an alternative to the age-cohort model. Our approach is based on a risk function that links mesothelioma mortality combined with data pertaining to the population, size of the labor force, and quantity of asbestos imports. We projected the number of deaths occurring in individuals aged 50-89 for yr 2003-2050 using risk functions. Our results have indicated that mesothelioma mortality among Japanese people aged 50-89 yr will continue to increase until 2027 and reach a maximum of 66,327 deaths in the years 2003-2050. Our estimate has also suggested that the number of mesothelioma deaths could be significantly reduced if there were adequate compliance with the administrative level guidelines for occupational asbestos exposure.

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Global Use of Asbestos and the Incidence of Mesothelioma

Cited by 110 publications

References 9 publications

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

Mortality in the French cohort of nuclear workers

Future Trends of Mesothelioma Mortality in Japan Based on a Risk Function

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