Global use of folk medicinal plants against hypercholesterolemia: A review of ethnobotanical field studies

Aumeeruddy, Muhammad Zakariyyah; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.hermed.2022.100536

Cited by 4 publications

(1 citation statement)

References 111 publications

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“…Treatment strategies for dyslipidemia comprise pharmacological (FDA, 2015) and nonpharmacological methods, namely, medicinal plants (Bye & Linares, 2016;Alonso et al, 2017;Aumeeruddy & Mahomoodally, 2022) that contain bioactive compounds or phytochemicals shown to reduce serum lipid levels, e.g., phenolic compounds, flavonoids, and betalains (Ramchoun et al, 2012;Ma et al, 2015;Tacherfiout et al, 2018;Salazar-Gomez et al, 2019;Yahaghi et al, 2020). Xoconostle fruit (O. joconostle) is a good source of the previously mentioned bioactive compounds (Osorio-Esquivel et al 2011;Morales et al, 2012;Morales et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Dyslipidemic effect of aqueous and ethanolic extracts of raw and roasted xoconostle (Opuntia joconostle) peel

Perez-Ramirez,

Garduño-Siciliano,

Alvarez-González

et al. 2024

BLACPMA

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The aim of the present study was to assess the impacts of roasting and the type of extraction solvent (ethanol or water) on the hypolipidemic activity of xoconostle fruit peel extracts in a tyloxapol-induced model of hyperlipidemia. Water and ethanol extracts from raw and roasted Opuntia joconostle peels were obtained to quantify the phytochemicals contained within and assess their hypolipidemic activity in rats (n=5) against tyloxapol-induced dyslipidemia (400 mg/kg). The raw ethanol and water extracts, as well as the roasted water extract (200 mg/kg), showed hypolipidemic activity in the tyloxapol-treated group (p<0.05). In contrast, the roasted sample extracted with ethanol did not show this effect. The concentrations of phenolic compounds (39.80 mg GAE/g) and flavonoids (16.42 ±0.14 mg QE/g) were higher in the ethanolic extracts than in the aqueous extracts. Conversely, the concentration of betalains (115.51 ±1.66 mg/100 g) was higher in the water extracts than in the ethanol extracts. It was concluded that the roasting process modified the concentration of some phytochemicals and their antioxidant capacity in vitro, producing a hypolipidemic effect in tyloxapol-induced hyperlipidemic rats.

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