Global Validation of Linear Model Assumptions

Peña, Edsel A.; Slate, Elizabeth H.

doi:10.1198/016214505000000637

Cited by 403 publications

(303 citation statements)

References 21 publications

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“…For each model, regression assumptions were evaluated using a global validation procedure. 26 To meet regression assumptions, pregnancy values of IL-10, TNF-a, and CRP required a log transformation. Pregnancy values of IL-6 satisfied all regression assumptions.…”

Section: Discussionmentioning

confidence: 99%

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Simpson

Steiner

Coote

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: Perinatal depressive symptoms often co-occur with other inflammatory morbidities of pregnancy. The goals of our study were 1) to examine whether changes in inflammatory markers from the third trimester of pregnancy to 12 weeks postpartum were associated with changes in depressive symptoms; 2) to examine whether third trimester inflammatory markers alone were predictive of postpartum depressive symptoms; and 3) to examine the relationship between inflammatory markers and depressive symptoms during the third trimester of pregnancy and at 12 weeks postpartum. Methods: Thirty-three healthy pregnant women were recruited from the Women's Health Concerns Clinic at St. Joseph's Healthcare in Hamilton, Canada. The impact of depressive symptoms on the levels of interleukin (IL)-6, IL-10, tumor necrosis factor alpha (TNF-a), and C-reactive protein (CRP) at the third trimester of pregnancy, at 12 weeks postpartum, and across time was assessed using linear and mixed-model regression. Results: Regression analysis revealed no significant association between depressive symptoms and any of the candidate biomarkers during pregnancy, at 12 weeks postpartum, or over time. Pregnancy depressive symptoms (p 4 0.001), IL-6 (p = 0.025), and IL-10 (p = 0.006) were significant predictors of postpartum Edinburgh Perinatal Depression Scale (EPDS) score. Conclusions: Our study supports previous reports from the literature showing no relationship between inflammatory biomarkers and depressive symptoms during late pregnancy, early postpartum, or across time. Our study is the first to observe an association between late pregnancy levels of IL-6 and IL-10 and postpartum depressive symptoms. Further studies with larger samples are required to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Simpson

Steiner

Coote

et al. 2016

Rev. Bras. Psiquiatr.

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“…The distances from the coast of walrus migrations routes drawn at different map scales (objective 4) were compared using a non-parametric Wilcoxon test. The package gvlma (global validation of the linear model assumptions) was used to confirm that the models' assumptions were respected (Pena and Slate 2006). For each explanatory variable (also called independent variable) the degree of freedom (df), the Fisher value (F) and p value (p) were reported.…”

Section: Statistical Analysesmentioning

confidence: 99%

Challenges and strategies when mapping local ecological knowledge in the Canadian Arctic: the importance of defining the geographic limits of participants’ common areas of observations

et al. 2017

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“…Comparison of different models for the same response variable(s) was done using ANOVA. Data analysis was conducted in program R v. 3.0.1 (R Core Team 2013) using package "gvlma" (Pena and Slate 2012).…”

Section: Discussionmentioning

confidence: 99%

Height increment of hybrid aspen <i>Populus tremuloides</i> x <i>P. tremula</i> as a function of weather conditions in central part of Latvia

Jansons¹,

Zeps²,

Rieksts-Riekstiņš³

et al. 2014

Silva Fenn.

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Height increment of hybrid aspen Populus tremuloides × P. tremula as a function of weather conditions in south-western part of Latvia Jansons Ā., Zeps M., Rieksts-Riekstiņš J., Matisons R., Krišāns O. (2014). Height increment of hybrid aspen Populus tremuloides × P. tremula as a function of weather conditions in southwestern part of Latvia. Silva Fennica vol. 48 no. 5 article id 1124. 13 p. Highlights• Intra-annual height growth of hybrid aspen was monitored.• Clones with early leaf flushing dates showed faster height growth.• Height growth was generally controlled by temperature.• Fast-growing hybrids were more robust to weather conditions than slow-growing ones.• Potential evapotranspiration (moisture regime) negatively affected height growth of clones with delayed phenology. AbstractHeight growth of young hybrid aspen (Populus tremula L. × P. tremuloides Michx.) was studied in relation to weather conditions. Height of clones with different leaf flushing phenology (early, intermediate and late) was monitored during the growing periods of 2010 and 2011 in a plantation established on former agricultural land. Mean daily height increment (HI) was calculated. Multiple linear regression was used to determine which weather factors (variables) had significant effect on HI. Mean seasonal height growth (mean seasonal HI) between clones (groups) was compared by ANOVA. In both years, HI was significantly higher for clones with early and intermediate leaf flushing compared to clones with late leaf flushing. The effect of weather factors also differed between clones according to their leaf flushing phenology; it was the weakest for HI of clones with early leaf flushing compared to clones with intermediate and late leaf flushing. Mean temperature was the main factor, which positively affected HI of all clones, suggesting that warmer climate might be beneficial for height growth of young hybrid aspen in Latvia. Nevertheless, significant negative relationship between HI and potential evapotranspiration (PET) was observed for clones with delayed leaf flushing, suggesting negative effect of increasing variability of precipitation on growth. Thus, the differences in height growth intensity might be related to growth sensitivity to weather conditions. On the other hand, such differences in height growth between clones might be caused by competition (i.e. with herbs), as trees with early leaf flushing might conquer more resources and become more robust against the environmental fluctuation.

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Global Validation of Linear Model Assumptions

Cited by 403 publications

References 21 publications

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Relationship between inflammatory biomarkers and depressive symptoms during late pregnancy and the early postpartum period: a longitudinal study

Challenges and strategies when mapping local ecological knowledge in the Canadian Arctic: the importance of defining the geographic limits of participants’ common areas of observations

Height increment of hybrid aspen <i>Populus tremuloides</i> x <i>P. tremula</i> as a function of weather conditions in central part of Latvia

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