The inability of Ghana's capture-based fisheries to meet national demand has placed aquaculture in an advantageous position to satisfy this supply deficit. The majority of fish farmers in Ghana, however, resort to local feed mixtures, occasionally in combination with commercial aquafeeds, demonstrating that the sector has not yet reached its full potential in terms of production volumes and efficiency. Fish meal is available in limited quantities and is prohibitively expensive in Ghana, making it essential to develop suitable complete and supplementary diets using low-cost and locally available plant by-products for use in fish grow-out facilities, particularly in tilapia production, which accounts for over 80 % of aquaculture production. This review thus identifies local agro-industrial byproducts with potential use in fish feeds based on their nutritional composition, total annual production, competition for and seasonal availability and dynamics of these products as well as prices. The effects of dietary inclusions of these by-products on fish growth and feed utilisation are also reviewed. Based on the published works and other practical information reviewed, these by-products represent huge potentials as alternative aquafeed protein sources because of their abundance, very affordable prices and healthy nutritional profiles for fish growth. Although this review focuses on Ghana, it can also be of direct benefit to fish farmers, feed manufacturers, researchers and the policy-makers in other regions of the world where these crops and their resulting by-products are produced in commercial quantities.