This explanatory study is intended to determine precursors of pollen allergies, an anthropo-economic perspective. In a nutshell, it deals with how pollen allergy is produced, circulated and dealt with in the setting of twin cities; Islamabad and Rawalpindi. Medically, allergies can be prevented but not cured. The cultural means of prevention and care are always preferred by the needs of the body, health, age and disease accordingly. The word anthropo is inconsistently used in a way human deal socio-culturally with the issue. Objective: The paper attempts to examine some environmental and socio-cultural determinants of pollen allergies in Rawalpindi and Islamabad. Materials and Methods: Socio-Economic Survey Form, FGD checklist, interview guide and life histories were prepared to collect data in order to unveil the cultural mythology on pollen allergies. The study reveals that �the livings of pollen patients have seen under the lenses of cultural economy�.